Acute leukemia following inflammatory bowel disease

Hanauer, Stephen B.; Wong, Kwan-Yee K.; Frank, P; Sweet, Donald L.; Kirsner, Joseph B.

doi:10.1007/bf01296735

Cited by 32 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ascertainment has been based on multiple sources, including physician notifications, pathology, hospitalizations, mortality and autopsy records (4,5). Other literature reports have also described both myeloid and lymphoid malignancies in Crohn's disease (3,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Fréquence Des Tumeurs Myéloïdes Lymphoïdes Et Intestinales mentioning

confidence: 99%

“…In 1979, Greenstein et al (6) described an excess of lymphomas in 1227 patients with Crohn's disease thought to be related to associated immunological deficiencies, use of immunosuppressive medications, or increased exposure to ionizing radation. In 1982, Hanauer et al (7) reported the presence of leukemia in Crohn's disease. Later, additional cases of Crohn's disease with either myeloid or lymphoid malignancies, including both Hodgkin's and nonHodgkin's lymphoma, were recorded (8)(9)(10)(11)(12)(13)(14).…”

Section: Fréquence Des Tumeurs Myéloïdes Lymphoïdes Et Intestinales mentioning

confidence: 99%

See 1 more Smart Citation

Tabulation of Myeloid, Lymphoid and Intestinal Malignancies in Crohn’s Disease

Freeman

2002

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

A variety of malignant complications occur in Crohn's disease, and previous studies have recorded an increased intestinal cancer risk. The present investigation tabulated myeloid and lymphoid malignancies compared with intestinal cancers in 1000 consecutively evaluated patients with Crohn's disease who were followed over an extended period by a single clinician. Myeloid and lymphoid neoplasms were present in 0.5% of patients, while cancer in the intestinal tract was detected in 1%. Most of these patients with a malignancy had Crohn's disease for a prolonged period of more than 20 years and had negative outcomes, including death or presentations with advanced disease. In this cohort, lymphoma was not detected in a single patient after definition of Crohn's disease, possibly reflecting the limited use of immunosuppressives or infused biological agents in this clinical practice. Bypassed rectal 'stumps' were associated with subsequent colorectal cancer in half of all males with colon cancer in this series, suggesting an important risk factor following colectomy in Crohn's disease. Epithelial dysplasia was detected in only a single male patient before colorectal cancer, implying that this histopathological marker may be a poor predictor of subsequent colon cancer development in Crohn's disease, an inflammatory bowel disease process that is typically patchy or focal in distribution in the intestinal tract.

show abstract

Section: Fréquence Des Tumeurs Myéloïdes Lymphoïdes Et Intestinales mentioning

confidence: 99%

Section: Fréquence Des Tumeurs Myéloïdes Lymphoïdes Et Intestinales mentioning

confidence: 99%

Tabulation of Myeloid, Lymphoid and Intestinal Malignancies in Crohn’s Disease

Freeman

2002

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…50 Fabry et al observed 5 AML cases among 400 ulcerative colitis patients treated over an 8-year period. This was followed by a number of case reports and case series that suggested an association between inflammatory bowel disease and hematologic malignancies, in particular Crohn's disease to lymphoma and ulcerative colitis to leukemia, [51][52][53][54][55][56][57][58][59] as summarized in Table 2. There are 18 case reports of AML developing in patients with inflammatory bowel diseases.…”

Section: The Association Between Inflammatory Bowel Diseases and Myelmentioning

confidence: 99%

Acute myeloid leukemia developing in patients with autoimmune diseases

Ramadan

Fouad

Summa³

et al. 2011

Haematologica

View full text Add to dashboard Cite

“…There has been an increased incidence of AML and MDS5 noted overall in patients with ulcerative colitis6 and CD7, 8 even in the pre-immunomodulatory era, suggesting an association between inflammatory bowel disease (IBD) itself and these hematopoietic malignancies. However, there have been few reports of 6-MP treatment associated AML in IBD with classically associated cytogenic abnormalities as we demonstrate here 9.…”

Section: To the Editorsmentioning

confidence: 99%