Acute leukemia in adult Hispanic Americans: a large-population study

Swords, Ronan; Sznol, Joshua; Elias, Roy; Watts, Justin M.; Zelent, Arthur; Martin, Eden R.; Vargas, Fernando; Bethel-Ellison, S; Kobetz, Erin

doi:10.1038/bcj.2016.94

Cited by 15 publications

(16 citation statements)

References 12 publications

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“…8,10 In addition, age-adjusted OS was surprisingly worse in Hispanics, a result particularly intriguing when seen in context with the so-called Hispanic epidemiologic paradox. 18 Finally, in our study, we attempted for the first time to compare the genomic profile of myeloid neoplasms between the 2 ethnic groups.…”

Section: Resultsmentioning

confidence: 99%

“…[5][6][7] Hispanics are known to have higher rates of B-cell acute lymphoblastic leukemia and acute promyelocytic leukemia (APL), but there exist no definitive data on epidemiologic or outcome differences in non-APL AML compared with whites. [8][9][10] We compare the baseline characteristics and treatment outcomes of Hispanic and white AML patients. Such ethnic differences should trigger study of their potentially biologic basis that would contribute to the everlasting struggle to eliminate disease outcome disparities in minorities.…”

Section: Introductionmentioning

confidence: 99%

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Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

et al. 2017

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“…Mexico City and Hispanic children in general have one of the highest incidences and mortality rates of this cancer. Additionally, more than half of these children (58.8%) are classified with a high risk of relapse at the moment of diagnosis confirmation [1,2]. In Mexico City, ALL represents the second cause of death in children aged between 1 and 14 years [3], with an annual incidence of 49.5 cases per million children under 15 years old [1].…”

Section: Introductionmentioning

confidence: 99%

Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Mata-Rocha

Rangel-López

Jiménez‐Hernández

et al. 2019

IJMS

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Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.

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“…The most treatable form of AML is acute promyelocytic leukemia (APL), a highly curable disease by treatment with arsenic trioxide and all-trans retinoic acid (Swords et al, 2016).…”

Section: Acute Myeloid Leukemia (Aml)mentioning

confidence: 99%

“…Unfortunately, the incidence of ALL has continued to climb significantly in all racial and ethnic groups over the last 20 years. The incidence of ALL in the United States is much higher in the Hispanic population compared with other races and ethnicities ( Pollyea et al 2014 ; Swords et al 2016 ; Shoag et al 2020 ). Notably, the rate of increase in ALL incidence in the Hispanic population is over twofold faster compared with non-Hispanic groups ( Shoag et al 2020 ).…”

Section: Acute Leukemiasmentioning

confidence: 99%

Blood cancer health disparities in the United States Hispanic population

Bencomo‐Alvarez

Rubio

Gonzalez

et al. 2021

Cold Spring Harb Mol Case Stud

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Cancer is a challenging, multifaceted disease that involves a combination of biological and non-biological factors. Aside from COVID-19, cancer is the second leading cause of death in the United States (U.S.), and the first among Hispanic Americans. The Hispanic population is the largest minority group in the U.S., which is rapidly growing in size. Unfortunately, U.S. Hispanics and other minority groups experience many different health disparities, resulting in poor survival outcomes and a reduced quality of life. Factors such as genomic mutations, lower socioeconomic status, lack of education, reduced access to health care, comorbidities, and environmental factors all contribute to these health care inequalities. In the context of blood cancer health disparities, Hispanic patients are often diagnosed at a younger age and have worse outcomes compared with non-Hispanic individuals. In the present article, we highlight the existing knowledge about cancer health disparities in the Hispanic population, with a focus on chronic and acute leukemia. In our experience at the U.S./Mexico border, analysis of several different blood cancers demonstrated that younger Hispanic patients with acute lymphoid or myeloid leukemia have higher incidence rates and worse prognoses. A combined approach, involving improved health care access and better knowledge of the underlying factors, will allow for more timely diagnoses and the development of intervention strategies aimed at reducing or eliminating the disparities.

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Acute leukemia in adult Hispanic Americans: a large-population study

Cited by 15 publications

References 12 publications

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

Blood cancer health disparities in the United States Hispanic population

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