2009
DOI: 10.1002/jat.1425
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Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum

Abstract: The metabonomic approach has been widely used in toxicology to investigate mechanisms of toxicity. In the present study alterations in the metabolic profiles, monitored by (1)H-NMR spectroscopy, on serum samples in acetaminophen (APAP)-induced liver injury in rabbits were examined. Furthermore, the effect of the established antidote N-acetylcysteine (NAC) and the proposed antidotes silybinin (SIL), cimetidine (CIM) and SIL/CIM was also investigated. A single dose of APAP (2 g kg(-1) b.w., i.g.) was administere… Show more

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Cited by 14 publications
(7 citation statements)
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“…Similarly, co-administration of silybinin (a component of silymarin), cimetidine, and NAC, 30 min after APAP administration, was reported to be an effective antidote combination in a rabbit demonstration model [10]. Accordingly, we assume that a concomitant administration of NAC and silymarin may be an effective antidote for the treatment of subjects with delayed therapy after APAP overdose.…”
Section: Plasma Liver Enzymes Testmentioning
confidence: 99%
“…Similarly, co-administration of silybinin (a component of silymarin), cimetidine, and NAC, 30 min after APAP administration, was reported to be an effective antidote combination in a rabbit demonstration model [10]. Accordingly, we assume that a concomitant administration of NAC and silymarin may be an effective antidote for the treatment of subjects with delayed therapy after APAP overdose.…”
Section: Plasma Liver Enzymes Testmentioning
confidence: 99%
“…Then, N ‐acetylcysteine (NAC), a precursor of glutathione, is recognized as an effective antidote for the side effects of APAP overdose, and has been used in the treatment of APAP‐induced liver injury. However, acute liver injury is still found in some patients despite NAC administration [12,13]. Therefore, the search for new functional materials against APAP‐induced liver injury is of current interest.…”
Section: Introductionmentioning
confidence: 99%
“…However, acute liver injury is still found in some patients despite NAC administration. [12,13] Therefore, the search for new functional materials against APAP-induced liver injury is of current interest.…”
Section: Introductionmentioning
confidence: 99%
“…For example, NMR-based metabolic profiling provides an insight into mechanisms of toxic effects induced by toxins or xenobiotic, and can detect a variety of metabolites simultaneously (Beckonert et al 2010;Lindon et al 2009;Michopoulos et al 2010;Vinaixa et al 2010). In addition, multivariate statistical analysis, including data reduction and pattern recognition (PR) analysis, such as principal components analysis (PCA) and partial least squares-discriminant analysis (PLS-DA), can efficiently reduce NMR spectral data and visualize the similarities between different groups (Andreadou et al 2009;Zhou et al 2009;Zira et al 2009). …”
Section: Introductionmentioning
confidence: 99%