Acute liver failure in low-income and middle-income countries

The “Hub and Spoke” model: a pathway for urgent plasma exchange to treat patients with rodenticide ingestion induced acute liver failure in Tamil Nadu, India

“… 1 As highlighted recently in The Lancet Gastroenterology and Hepatology , high mortality in low-resource settings is attributable to lack of access to urgent liver transplantation. 2 Annually, only about 50–75 ALF patients undergo urgent liver transplantation in India. 3 Specific criteria to list RH patients for urgent liver transplantation (model for end-stage liver disease score ≥36 or baseline prothrombin time–international normalized ratio ≥6 with hepatic encephalopathy) were proposed from Kochi in Kerala state.…”