Acute Liver Injury and Failure

Thawley, Vincent J.

doi:10.1016/j.cvsm.2016.11.010

Cited by 61 publications

(41 citation statements)

References 71 publications

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“…Unclear information was further clarified by directly contacting the specific clinicians who were responsible for the patients. The diagnostic criteria of acute respiratory distress syndrome (ARDS), acute cardiac injury, acute renal injury and acute liver injury were based on the corresponding guidelines [11][12][13][14]. Additionally, treatment medication and outcomes of the enrolled cases were also collected based on the medical records.…”

Section: Methodsmentioning

confidence: 99%

Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

Huang

Zhu

Xue³

et al. 2020

PLoS Negl Trop Dis

217

119

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Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0-54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI) � 28 kg/m 2 (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P<0.001) and a known history of type 2 diabetes PLOS NEGLECTED TROPICAL DISEASES PLOS Neglected Tropical Diseases | https://doi.org/10.1371/journal.pntd.

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Section: Methodsmentioning

confidence: 99%

Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

Huang

Zhu

Xue³

et al. 2020

PLoS Negl Trop Dis

217

119

View full text Add to dashboard Cite

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“…Leucaena leucocephala procesada para alimentación de conejos ocasiona edema e hígado congestionado con manchas necróticas (Fayemi et al, 2011) y densa inflamación crónica del hígado (Adekojo et al, 2014). Por otro lado, la magnitud del incremento en la ALT, observada también en este estudio (Cuadro 2), refiere al grado de lesión de los hepatocitos (Thawley, 2017).…”

Section: Resultados Y Discusiónunclassified

Concentración sérica de aminotransferasas en cuyes (Cavia porcellus) alimentados con dietas basadas en pisonay (Erythrina sp)

Ramirez-Borda

Cárdenas-Villanueva

Riva

et al. 2019

Rev. investig. vet. Perú

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El experimento se llevó a cabo en Tamburco, provincia de Abancay, Perú, con el objetivo de determinar el efecto de dietas basadas en pisonay (Erythrina sp) sobre la concentración de taninos y alcaloides totales, la concentración sérica de las aminotransferasas, las lesiones en el hígado y la relación hígado/peso vivo de los cuyes. Se utilizaron hojas y peciolos de pisonay con cuatro meses de rebrote y alfalfa fresca (Medicago sativa) con 28 días de rebrote en la dieta de 24 cuyes machos mejorados, distribuidos en tres tratamientos: dieta A100: 100% alfalfa (80 g), dieta A50P50: 50% alfalfa (40 g) más 50% pisonay (40 g) y dieta P100: 100% pisonay (80 g). El alimento fue suministrado dos veces al día. Los niveles séricos y la relación hígado/peso vivo fueron analizados con diseño completo al azar, el efecto de las dietas sobre las lesiones del hígado de cuyes se analizó con el test exacto de Fisher. La concentración de taninos en el pisonay (14.0 g/kg MS) fue superior a los hallados en alfalfa (2.2 g/kg MS). En la alfalfa no se detectaron alcaloides totales. Los niveles séricos de alanino aminotransferasa (ALT) en cuyes alimentados con A100 (39.1 ± 7.2 UI/L), A50P50 (48.8 ± 7.1 UI/L) y P100 (62.0 ± 8.4 UI/L) mostraron diferencias significativas (p<0.05). La aspartato aminotransferasa (AST) en cuyes alimentados con A50P50 (71.9 ± 15.2 UI/L) y P100 (76.4 ± 11.8 UI/L) fueron superiores a los animales alimentados con A100 (p<0.05). El incremento de 50 a 100% de pisonay en la dieta de cuyes produce lesiones en el hígado como degeneración grasa y focos necróticos, además de disminuir la relación hígado/peso vivo. El pisonay como forraje fresco en 50 y 100% en la dieta de cuyes pueden afectar adversamente la salud de los animales.

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“…Acute liver failure (ALF) is a clinical syndrome that involves sudden and massive liver cell death and liver dysfunction, resulting in coagulopathy, encephalopathy and circulatory dysfunction, thereby leading to multiple organ failure [21,22]. It was reported that the over expression of SND1 was associated with a chronic in ammatory state of leading to hepatocellular carcinoma cell [13].Nevertheless, the relationship betweenSND1 expression and acute in ammation in the liver remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Effect of the Hepatocyte-Specific Deletion of SND1 in Mice on the Liver Insulin Resistance and Acute Liver Failure

Zhao¹,

Cui²,

Bian³

et al. 2020

Preprint

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Background: The multifunctional protein SND1 was reported to be involved in a variety of biological processes, such as cell cycle, proliferation or lipogenesis. We previously proposed that global-expressed SND1 in vivo is likely to be a key regulator for ameliorating HFD-induced hepatic steatosis and systemic insulin resistance. Herein, we are very interested in investigating further whether the hepatocyte-specific deletion of SND1 affects the insulin resistance or acute liver failure (ALF) of mice.Methods: By using Cre-loxP technique, we constructed conditional knockout (LKO) mice of SND1 driven by albumin in hepatocytes and analyze the changes of glucose homeostasis, cholesterol level, hepatic steatosis and hepatic failure under the treatment of high-fat diet (HFD) or upon the simulation of Lipopolysaccharide/galactosamine (LPS/GalN).Results: No difference for the body weight, liver weight, and cholesterol level was detected. Furthermore, we did not observe the alteration of glucose homeostasis in SND1 hepatic knockout mice on either chow diet or high-fat diet. Besides, hepatocyte-specific deletion of SND1 failed to influence the hepatic failure of mice induced by LPS/GalN.Conclusions: These findings suggest that hepatic SND1, independently, is insufficient for changing glucose homeostasis, hepatic lipid accumulation and inflammation. The synergistic action of multiple organs may contribute to the role of SND1 in insulin sensitivity or inflammatory response.

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Acute Liver Injury and Failure

Cited by 61 publications

References 71 publications

Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study

Concentración sérica de aminotransferasas en cuyes (Cavia porcellus) alimentados con dietas basadas en pisonay (Erythrina sp)

Effect of the Hepatocyte-Specific Deletion of SND1 in Mice on the Liver Insulin Resistance and Acute Liver Failure

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