Acute localized exanthematous pustulosis: A novel side effect of piroxicam

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare yet well-known cutaneous reaction pattern, mostly caused by drugs. Acute localized exanthematous pustulosis (ALEP) is a localized variant of AGEP. A 42-year-old female presented with multiple erythematous pustules on the face, which appeared three days after the intramuscular injection of piroxicam. Histopathology revealed subcorneal pustules, epidermal spongiosis, and mixed inflammatory cell infiltration in the dermis. The pustules resolved within several days once the patient had discontinued the drug. Herein, we report the first case, as far as we know, of a female with a cutaneous drug reaction consistent with ALEP caused by piroxicam.

Acute generalized exanthematous pustulosis due to insect bites: Moroccan observation

“…Acute generalized exanthematous pustulosis is an acute pustular rash, the usual causes of which are the ingestion of medications and/or infection [3,4]. Cases of AGEP secondary to insect bites are exceptionally reported, probably because of the difficulty in establishing a causal relationship.…”