Acute Localized Exanthematous Pustulosis on the Face

Sim, Hyun Soo; Seol, Jung Eun; Chun, Ji Won; Seo, Jong Keun; Lee, Dong Hoon; Sung, Ho Suk

doi:10.5021/ad.2011.23.s3.s368

Cited by 18 publications

(23 citation statements)

References 13 publications

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“…Acute generalized exanthematous pustulosis eruptions typically start on the face and flexural folds and extend to the trunk and limbs . Localized AGEP has been reported over a mid‐sternal scar and on the face, cheeks and lips . Diltiazem has also been reported to induce AGEP limited to the distal limbs with sparing of the trunk and flexural folds .…”

Section: Introductionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.

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Section: Introductionmentioning

confidence: 99%

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

Kostopoulos

Krishna

Brinster

et al. 2014

Acad Dermatol Venereol

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“…Previous studies in patients with AGEP have revealed a high rate of positive patch test responses and in vitro, lymphocyte-proliferative responses compared with other drug eruptions, suggesting that the reaction occurs due to a drug-specific, T-cell-mediated process [25]. All of our patients, though, presented negative patch tests to formaldehyde.…”

Section: Discussionmentioning

confidence: 54%

Eczema-Like Psoriasiform Skin Reaction due to Brazilian Keratin Treatment

Gavazzoni-Dias

Rochael

Vilar

et al. 2015

Skin Appendage Disord

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The use of formaldehyde and formaldehyde releasers in hair-straightening formulations started in Rio de Janeiro in 2003. The technique is known as BKT, Brazilian keratin treatment. The aim of this study was to analyze the types of skin reactions presented by patients due to BKT. We describe 7 patients with severe erythema and scurf on the scalp which developed shortly after BKT. The lesions were eczema-like psoriasiform, located mainly on the scalp. Some patients also developed eczema-like lesions and pustules on the face, neck, upper arms, and upper trunk. Dermatoscopic findings included erythema, perifollicular and interfollicular scurf. The peripilar desquamation resembled the outer skin of an onion bulb. Scalp biopsies revealed psoriasiform and spongiotic psoriasiform patterns, one of them similar to anti-TNFα biologic drug psoriasiform alopecia. The possible consequences of the absorption of formaldehyde by hairdressers or clients are still to be verified by the scientific community; however, the skin and scalp reactions observed in our cases suggest a drug reaction phenomenon and not only eczemas of irritant or allergic origin.

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“…We do not know the reason why there was no lesion on the left upper chest of the patient. Though localized cases of AGEP have been reported mostly on the face, to date there is no case report such as ours with sparing of a localized part of the body . We do not know the exact mechanism, but the sparing of the left upper chest might be related to the sternotomia scar as there are no lesions beyond that area.…”

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confidence: 66%