Acute Lung Injury in a Rat Model of Intestinal Ischemia-Reperfusion: The Potential Time Depended Role of Phospholipases A2

Kostopanagiotou, Georgia; Avgerinos, Efthimios D.; Costopanagiotou, Constantinos; Arkadopoulos, Nikolaos; Andreadou, Ioanna; Diamantopoulou, Kalliopi; Lekka, Marilena E.; Smyrniotis, Vassilios; Nakos, George

doi:10.1016/j.jss.2007.07.023

Cited by 33 publications

(34 citation statements)

References 40 publications

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“…Our findings implicated a critical role of TLR4 signaling in lung inflammatory injury triggered by intestinal I/R. Secondary lung inflammatory response plays a key role in the pathogenesis of acute lung injury in gut I/R [13][14][15], but the mechanisms of this process are poorly understood. Accumulation of neutrophils in the lung is a prominent feature of ALI after intestinal I/R [16].…”

Section: Discussionmentioning

confidence: 82%

TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

Ben¹,

Yu²,

Ji³

et al. 2012

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 82%

TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

Ben¹,

Yu²,

Ji³

et al. 2012

Journal of Surgical Research

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“…Ischemia-reperfusion (I/R) injury is one of the main factors affecting the function and structure of SBT, by generation of proinflammatory mediators such as reactive oxygen species, reactive nitrogen species (e.g., NO), cytokines (e.g., TNF, IL-8). and endotoxin [2][3][4][5][6]. The generated cascade may activate leukocytes and endothelial cells, which ultimately lead to tissue inflammation, multiple organ dysfunction, and death [7].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of NAC Preconditioning Against Ischemia-Reperfusion Injury in Piglet Small Bowel Transplantation: Effects on Plasma TNF, IL-8, Hyaluronic Acid, and NO

Kostopanagiotou

Avgerinos

Markidou

et al. 2011

Journal of Surgical Research

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“…Among the therapeutic modalities able to mitigate the harmful effects of local and remote I/R, there are the use of: antioxidants and anti-inflammatory medications (Kostopanagiotou et al 2007, Avgerinos et al 2010, Yurdakan et al 2012, use of propofol (Vasileiou et al 2012), green tea (Abdeen et al 2011), hydrocortisone (Alves et al 2011), rutin (Itagaki et al 2010), glutamine (Pagliosa et al 2009), methylene blue (Greca et al 2008), dimethyl sulfoxide (DMSO) (Dabareiner et al 2005), copaiba oils (Paiva et al 2004), among others.…”

Section: Introductionmentioning

confidence: 99%

Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits

et al. 2018

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The present study aimed to evaluate the efficacy of mesenchymal stem cell (MSC) infusion, derived from adipose tissue, on reduction of local and remote tissue damage caused by the event of experimental intestinal I/R in New Zealand breed rabbits. For obtaining, characterization, and cultivation of MSC derived from adipose tissue (MSC-Adp), 3 juvenile animals (four months old) were used. The cells were considered to be viable for therapy after the fourth passage (in vitro phase). For the in vivo stage, 24 young adult animals (six months old) were used, weighing approximately 3.5 kg, in which were randomly divided into two groups, called: IR treated with MSC (I2H/R5H MSC 3D; I2H/R5H MSC 7D); IR treated with PBS (I2H/R5H PBS 3D; I2H/R5H PBS 7D). The animals were anesthetized and submitted to pre-retro-umbilical midline celiotomy. The extramural peri-intestinal marginal artery was located and clamped (predetermined and standardized region) with the aid of a vascular clip, promoting a 2 hour blood flow interruption. After this period, blood flow was reestablished, inhalatory anesthesia was suspended, and the animals awaken. After 5 hours of reperfusion, the treatments were performed by intravenous infusion according to the experimental groups. The animals were evaluated 72 hours and seven days after the treatment as for the macroscopic appearance (color and peristaltism) of the jejunal segment, and by histological evaluation of the ischemic segment for the presence or absence of destruction of the intestinal mucosa, edema, bleeding, dilation of lymph vessels, and presence of polymorphonuclear inflammatory cells, both in the mucosa and submucosa. The observed results revealed that the groups treated with MSC-Adp obtained smaller mucosal and submucosal lesions when compared to the groups treated with PBS. Also, MSC-Adp treated groups obtained controlled inflammatory response and higher mitotic rate, outcomes related to the therapeutic potential of MSC. Infusion of stem cells attenuated the lesions caused by intestinal I/R in both MSC groups when compared to the group treated with PBS.

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Acute Lung Injury in a Rat Model of Intestinal Ischemia-Reperfusion: The Potential Time Depended Role of Phospholipases A2

Cited by 33 publications

References 40 publications

TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

TLR4 Mediates Lung Injury and Inflammation in Intestinal Ischemia-Reperfusion

Protective Effect of NAC Preconditioning Against Ischemia-Reperfusion Injury in Piglet Small Bowel Transplantation: Effects on Plasma TNF, IL-8, Hyaluronic Acid, and NO

Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits

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