Acute Lymphoblastic Leukaemia with Microfilaria: A Rare Coincidence in Bone Marrow Aspirate

Arundhati,; Kumar, Ashok; Kumar, Rakesh

doi:10.1007/s12288-011-0066-2

Cited by 17 publications

(14 citation statements)

References 2 publications

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“…Uzma Zafar et al (8) reported an interesting case of low back pain and destruction of first lumbar vertebra by the microfilariae residing in the bone marrow. There were several case reports of huge splenomegaly in leukaemia patients with incidental detection of bone marrow microfilariae (9)(10)(11). Possible explanation for splenomegaly in those cases were due to leukaemia not filariasis because spleen is usually not involved in filariasis except in some experimentally infected animals although Schuurkamp GJ et al (14) showed occurrence of filarial splenomegaly in their articles.…”

Section: Discussionmentioning

confidence: 99%

Filarial huge splenomegaly dramatically regressed by anti-filarial medication: A rare clinical scenario

Basu

Kumar

Manchanda

et al. 2017

IRDR

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Section: Discussionmentioning

confidence: 99%

Filarial huge splenomegaly dramatically regressed by anti-filarial medication: A rare clinical scenario

Basu

Kumar

Manchanda

et al. 2017

IRDR

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“…However, it has been reported that in cases of bone marrow microfilaria, the above mentioned classical clinical presentation is often lacking [5][6][7][8][9][10][11][12]. Similarly our case also lacked the classical clinical presentation.…”

Section: Discussionmentioning

confidence: 56%

Blastic Phase of CML with Microfilaria: A Rare Case Report

Pahwa

Saksena

Singh

et al. 2015

JCDR

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A 37-year-old male, diagnosed case of CML on Imatinib mesylate, presented with low grade fever, weight loss and abdominal distension for one month. Physical examination revealed massive splenomegaly and hepatomegaly, however there was no lymphadenopathy.His hemoglobin was 10.5 g/dl, total leucocyte count was 52.31 x 109 / L with platelet count of 30 x 109/L. Differential leucocyte count on peripheral smear showed 21% blasts [Table/ Fig-1], 30% polymorphs, 16% lymphocytes, 1% myelocyte, 1%metamyelocyte, 30%monocytoid cells and 1% eosinophils. Blasts were large with high N: C ratio, pale basophilic cytoplasm, some of them showed 1-4 nucleoli. In addition, occasional microfilaria was also seen [Table/ Fig-2]. They were morphologically characterized as the microfilaria of W. bancrofti, as they were sheathed and lacked terminal nuclei.Bone marrow aspirate smears were diluted with blood. However, they showed blasts and monocytoid cells accounting for 25% and 15% of marrow nucleated cells respectively .The blasts had same Pathology SectionBlastic Phase of CML with Microfilaria: A Rare Case Report aBstRaCt Filariasis is a major public health concern in tropical and subtropical countries including India. There have been very few case reports of incidental filariasis in the bone marrow aspirate smears in patients with hematological malignancies. We present a case of blastic phase of chronic myeloid leukemia (CML) with associated filariasis with monocytosis. Such an association, to the best of our knowledge, is hitherto unreported. Moreover, eosinophilia was not a feature in our case.A 37-year-old male, diagnosed case of CML, presented with low grade fever, weight loss and abdominal distension for one month. Physical examination revealed massive splenomegaly and hepatomegaly. However, there was no lymphadenopathy. His hemoglobin was 10.5 g/dl, total leukocyte count was 52.31x 109 / L with platelet count of 30x 109/L .Differential leukocyte count on peripheral smear showed 21% blasts, 30% polymorphs, 16% lymphocytes, 1% myelocyte, 1%metamyelocyte, 30%monocytoid cells and 1% eosinophils.Bone marrow aspirate smears were diluted with peripheral blood and showed blasts and monocytoid cells constituting 25% and 15% of marrow nucleated cells respectively. In addition, occasional microfilaria of Wuchereria bancrofti were also seen both in the peripheral blood and aspirate smears.Based on the above findings, a diagnosis of blastic phase of CML with monocytosis with microfilaria of W.bancrofti.Hence this was an unusual case of CML blastic phase which was associated with filariasis. Moreover, inspite of having filariasis and CML, patient lacked eosinophilia and instead showed monocytosis, which is hitherto unreported.

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“…It is also possible that they may get trapped in the bone marrow during their circulation in the peripheral blood. Including the present case, none of the published cases where microfilaria was found in the bone marrow aspirates, had a classical clinical presentation of lymphatic filariasis (5)(6)(7)(8)(9)(10)(11). A diagnosis of filariasis was made after demonstrating the microfilariae in the bone marrow aspirate or in the peripheral blood smears.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 80%

Incidental Finding of Microfilariae in Bone Marrow Aspirate of a Patient With Tuberculosis: A Case Report.

MBBch¹,

Bashir²,

Khan³

2017

IJAR

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Acute Lymphoblastic Leukaemia with Microfilaria: A Rare Coincidence in Bone Marrow Aspirate

Cited by 17 publications

References 2 publications

Filarial huge splenomegaly dramatically regressed by anti-filarial medication: A rare clinical scenario

Filarial huge splenomegaly dramatically regressed by anti-filarial medication: A rare clinical scenario

Blastic Phase of CML with Microfilaria: A Rare Case Report

Incidental Finding of Microfilariae in Bone Marrow Aspirate of a Patient With Tuberculosis: A Case Report.

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