Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

Kersey, John H.; Sabad, Andrej; Gajl‐Peczalska, Kazimiera J.; Hallgren, Helen M.; Yunis, Edmond J.; Nesbit, Mark E.

doi:10.1126/science.182.4119.1355

Cited by 136 publications

(23 citation statements)

References 9 publications

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“…Ross et al [12] reported that there was not always a good correlation between the presence of surface immunoglobulins and the ability of human leukemic lymphocytes to form EAC rosettes. Interest ingly enough, almost all the cases of acute lymphatic leukemia have been reported to be of T lymphocyte origin [13][14][15], the only exceptions being the case of Gajl Pecjalska et al [16], who had no previous history of chronic lymphatic leukemia, and the two patients described by Brouet et al [3], who supervened on B cell chronic lymphatic leukemia. It is there fore impossible to state whether in our case the small lymphocytes of chronic lymphatic leukemia and the lymphoblasts were derived from the same clone of cells, were two completely unrelated phenomena, or were induced by a common pathogenic factor.…”

Section: Discussionmentioning

confidence: 99%

Acute Lymphoblastic Crisis in a Patient with Chronic Lymphatic Leukemia

Klajman¹,

Yaretzky²,

Manor³

et al. 1975

Acta Haematol

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A case of chronic lymphatic leukemia terminating in a lymphoblastic crisis is described. The small lymphocytes were demonstrated to be B cells, they carried immunoglobulins on their surface and formed EAC rosettes. The lymphoblasts had no immunoglobulins on their surface and only 18% of them formed EAC rosettes, none formed E rosettes. The lymphoblasts could be either immature B cells or Null cells.

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Section: Discussionmentioning

confidence: 99%

Acute Lymphoblastic Crisis in a Patient with Chronic Lymphatic Leukemia

Klajman¹,

Yaretzky²,

Manor³

et al. 1975

Acta Haematol

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“…Because they react with cells from many, but not all, cases of ALL, they will help to categorize different subtypes of leukemia and may shed light on the tissue origin of these malignant cells. Currently, the human ALLs are subdivided into T cell, pre-B cell, and null cell types according to their expression of certain markers of normal lymphocyte differentiation (27)(28)(29)(30). It is already clear that the antigen defined here is not limited to just the leukemias that carry other T-cell differentiation markers, because it is found on some "null" cell leukemias as well (Table 1).…”

Section: Methodsmentioning

confidence: 99%

A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.

Levy¹,

Dilley²,

Fox³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

169

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A series of mouse hybridomas producing monoclonal antibodies against human acute lymphocytic leukemia (ALL) cells was generated and screened for tumor specificity. Among 1200 primary cultures, 60 produced an antibody that could distinguish between the immunizing leukemia cells and an isologous B lymphoblastoid cell line. Of these, two produced an antibody that detects an antigen expressed preferentially on ALL cells and on a subpopulation of normal cells found in the cortex of the thymus. Other normal human lymphoid cells from lymph nodes, spleen, bone marrow, and peripheral blood express only low levels of this antigen. High levels of this "thymus-leukemia" antigen were found on T-ALL cells, T-ALL-derived cell lines, and some "null" ALL cells. By contrast, B-cell leukemias, B lymphoblastoid cell lines, and normal and malignant myeloid cells contain either low or undetectable amounts of this antigen. The thymus-leukemia antigen has been isolated from the membranes of leukemia cells by detergent solubilization and subsequent immunoprecipitation with the monoclonal antibody. Preliminary biochemical characterization shows the antigen to be associated with a polypeptide of Mr approximately 28,000.

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“…The study of the surface markers of lymphoid cells is of greatest usefulness not only for understanding normal immunity, but also in the analysis of neoplasia affecting the lymphopoietic system [12]. As for pediatric patients only, pathological cells of subjects with acute lymphocytic leukemia (ALL) have been found to possess in general impaired markers either for B or T cells [2,4,8,14,16,18].…”

Section: Discussionmentioning

confidence: 99%

Acute Disseminated Lymphosarcoma with B Cell Markers in a Child

Moscatelli¹,

Bricarelli²,

Quartino³

1976

Acta Haematol

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A case of a 4-year-old child with disseminated lymphosarcoma with meningeal involvement is described. Immunological investigations of the blast cells in the cerebrospinal fluid were carried out and in most of them Ig determinants and no response to PHA stimulation were found. So the B-dependent nature of these cells was ascertained. This observation is a contribution to the diagnosis of lymphoid malignancies through the evaluation of the immunological nature of the blast cells. The data of the literature are still scarce and inconclusive.

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Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

Cited by 136 publications

References 9 publications

Acute Lymphoblastic Crisis in a Patient with Chronic Lymphatic Leukemia

Acute Lymphoblastic Crisis in a Patient with Chronic Lymphatic Leukemia

A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.

Acute Disseminated Lymphosarcoma with B Cell Markers in a Child

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