Acute manifestations of male genital filariasis in Enugu, Nigeria

Nwafo, D C; Mbonu, O. O.; Egere, J. U.

doi:10.1080/00034983.1981.11687446

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…• Loss of libido and impotency [245,246] • Oligozoospermia to azoospermia in chronically infected men [245] Wuchereria bancrofti • Testis [247,248] • Hydrocele [249] • Epididymo-orchitis [247,249] • Atrophy of seminiferous tubules [250] • Recurrent scrotal pain and swelling [251] • Elephantiasis [250] • Oligozoospermia and non-motile spermatozoa [249] • Azoospermia [250] Guiton and Drevet Basic and Clinical Andrology (2023) 33:19 infected female mosquitoes and causes an acute febrile illness. In 2020, it was estimated that nearly half of the world's population was at risk of this parasite disease [253].…”

Section: Infected Genital Organs Damage To Genital Tract Organs Cause...mentioning

confidence: 99%

“…The majority of infections is first asymptomatic but when becoming chronic, it often leads to severe damage, especially genital damage as the lymphatics of the spermatic cord are a favoured location. Among the genital manifestations often described are recurrent scrotal pain and swelling, hydrocele, and epididymo-orchitis [247,[249][250][251]. Parasites have been shown to infect testis [247,248], and atrophy of the seminiferous tubules in association with azoospermia was seen in an Indian man with long-standing infertility [250].…”

Section: Wuchereria Bancroftimentioning

confidence: 99%

“…Among the genital manifestations often described are recurrent scrotal pain and swelling, hydrocele, and epididymo-orchitis [247,[249][250][251]. Parasites have been shown to infect testis [247,248], and atrophy of the seminiferous tubules in association with azoospermia was seen in an Indian man with long-standing infertility [250]. At least two other studies described oligozoospermia and non-motile spermatozoa in men originating from India and Nigeria [249,251].…”

Section: Wuchereria Bancroftimentioning

confidence: 99%

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Viruses, bacteria and parasites: infection of the male genital tract and fertility

Guiton

Drevet

2023

Basic Clin. Androl.

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Background Infertility affects one couple out of six worldwide. Male infertilty can result from congenital or acquired factors, of which pathogens that reach the genital tract through sexual contact or blood dissemination. The impact of major viral, bacterial and parasitic infections on the male genital tract and fertility has been summarized. Results and conclusions A systematic review of articles published in the Google Scholar and PubMed databases was conducted. It turns out that viruses, as well as bacteria and parasites are major inducers of male genital tract infections and ensuing infertility through damage to the organs and subsequent loss of function and/or through direct damage to the sperm cells. Moreover, not only male infertility results from such infections but these can also be transmitted to women and even to the offspring, thus highlighting the need to efficiently detect, treat and prevent them.

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Section: Infected Genital Organs Damage To Genital Tract Organs Cause...mentioning

confidence: 99%

Section: Wuchereria Bancroftimentioning

confidence: 99%

Section: Wuchereria Bancroftimentioning

confidence: 99%

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Viruses, bacteria and parasites: infection of the male genital tract and fertility

Guiton

Drevet

2023

Basic Clin. Androl.

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“…Virtually all cases from non‐endemic countries were imported cases of migrants native to endemic countries, with the exception of a case of genital LF diagnosed in a returning American serviceman [31]. One series of 32 emergency scrotal explorations from Nigeria found that 33 % of explorations and 88 % of orchiectomies performed for acute scrotum were found to have filarial epididymo‐orchitis on histopathology [32].…”

Section: Part 2: Case Reports Acute Surgery and Lymphatic Surgery For...mentioning

confidence: 99%

“…The pitfalls of performing a radical operation to remove a painless filarial lesion treatable with antihelminthics is obvious; less clear is the need for surgery in acute genital manifestations of LF. Nwafo et al suggest that the majority of their cases an unnecessary operation could have been avoided [32]. Acuity for atypical manifestations of genital LF is perhaps most important for surgeons working in endemic regions and those in non-endemic countries dealing with migrants from known areas.…”

Section: Atypical Manifestations Of Genital Lfmentioning

confidence: 99%

Surgical Treatment of Genital Manifestations of Lymphatic Filariasis: A Systematic Review

et al. 2015

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Genital manifestations of lymphatic filariasis (genital LF) are a significant cause of disfigurement and disability in the developing world. Surgery is the standard treatment; however, definitive publications are lacking and best practice remains unclear. An exhaustive search strategy using keyword and subject headings was applied to Medline, EMBASE, Web of Science, CINAHL, and Scopus. Additionally citation lists, Google and Google Scholar, archives of relevant journals and websites were searched systematically. Studies with data on one or more human patient(s) who underwent surgery for genital LF were included. Articles were screened and data extracted by the first author with data verification by the second author. Fifty-seven studies were included: 18 series of ablative surgery, four series of non-ablative surgery and 35 case reports. Poor study quality, heterogeneous case definitions, lack of severity grading and limited follow-up precluded meta-analysis. Two series of simple hydrocelectomies performed in resource-limited settings reported early complication rates of 3.0-3.5 % using eversion and 5-7 % using excision, with recurrence of 7 % and 3-5 %, respectively. Complications were minimal for single-surgeon series and greater (12-18 %) when scrotal reconstruction was performed. There is little useful evidence for lymphatic bypass procedures in genital LF. Under-recognition of atypical manifestation of genital LF leads to potentially unnecessary surgeries. Surgery for genital LF is safe in resource-limited settings; however, more well-designed studies with better follow-up are needed. Research priorities include validation of case definitions and severity grading systems, and solutions to improve post-operative follow-up in resource-limited settings.

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Testicular Torsion: Nigerian Experience

Udeh

1985

Journal of Urology

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The records of 80 patients at this institution diagnosed as having testicular torsion during a 5-year period were examined to establish the characteristics and peculiarities, if any, of the disease in Nigeria. There were 74 suitable cases. Similar symptoms and physical signs were identified in Nigeria as have occurred elsewhere. However, contrary to reports from Europe and America the majority (57 per cent) of the patients with testicular torsion in this study were 20 or more years old. Also, torsion occurred significantly more often (9 per cent) in men 30 or more years old than has been reported in other areas. Only 5 per cent of the patients were less than 10 years old. There is no ready explanation why testicular torsion becomes manifest during adulthood in Nigeria. The testes were explored in 73 cases. Of the testes 25 per cent could not be salvaged because of infarction with acute torsion. However, the immediate testicular salvage rate of 75 per cent does not necessarily ensure long-term normal exocrine and endocrine testicular function.

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Acute manifestations of male genital filariasis in Enugu, Nigeria

Cited by 4 publications

References 9 publications

Viruses, bacteria and parasites: infection of the male genital tract and fertility

Viruses, bacteria and parasites: infection of the male genital tract and fertility

Surgical Treatment of Genital Manifestations of Lymphatic Filariasis: A Systematic Review

Testicular Torsion: Nigerian Experience

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