Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients

Sultan, Sadia; Zaheer, Hasan Abbas; Irfan, Syed Mohammed; Ashar, Sana

doi:10.7314/apjcp.2016.17.1.369

Cited by 5 publications

(13 citation statements)

References 19 publications

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“…A study conducted in Pakistan revealed splenomegaly (16%), hepatomegaly (12.8%) and lymphadenopathy (10.4%). 8 These findings were consistent with our results. Mean Hb was 7.2 g/dl, mean Platelet count was 38×10³µl while Mean TLC was 37.17×10³µl.…”

Section: Discussionsupporting

confidence: 83%

“…This was comparable to the studies conducted previously in Pakistan showing mean age of 29 years and 34.5 years respectively. 7,8 This was also comparable to studies conducted in India where median age was 30 years and in Bangladesh where median age was 35 years. 9,10 However when mean age was compared with studies conducted in western countries, there was difference in the mean age at presentation.…”

Section: Discussionsupporting

confidence: 73%

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Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Naeem

Sharif

et al. 2017

TPMJ

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ABSTRACT… Background: Acute myeloid leukemia (AML) is an aggressive haematological malignancy with highest incidence in older adults. AML accounts for approximately 25% of all leukemias in adults in the Western world, and therefore is the most frequent form of leukemia. Patients on chemotherapy and radiotherapy were excluded from the study. Results: Among the 77 patients of Acute Myeloid Leukemia, Acute myeloid leukemia with maturation AML M2 (37.7%) was the most common subtype and the least common was Acute megakaryoblastic leukemia AML M7 (1.3%).Mean age for AML was 28 years (Range 15-75 years). M:F ratio was 1.5:1. Fever was found be the most frequent presenting feature followed by pallor, bleeding and gum hypertrophy in the descending order. More than 50% patients presented with hepatosplenomegaly. Lymphadenopathy was seen in 30% of patients. Mean peripheral blood blast count was 29%. 12 patients (15.5%) presented with pancytopenia. Conclusion: The study showed male predominance in Acute myeloid leukemia with mean age of 28 years and the most common subtype was AML-M2.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 73%

Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Naeem

Sharif

et al. 2017

TPMJ

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“…Anemia and thrombocytopenia are the consequence of bone marrow infiltration by leukemic myeloblasts. In the study of Sultan et al [17], anemia was noted in 81.6% of AML patients and thrombocytopenia in 84% of them. Untreated AML is a uniformly fatal disease.…”

Section: Resultsmentioning

confidence: 90%

Interleukin-8 as a Surrogate Marker in Risk Stratification of Patients with Acute Myeloid Leukemia

Almorish¹,

Al-Kahiry²,

Rabie³

et al. 2019

J Blood Lymph

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Introduction: When molecular and cytogenetic studies are not available, the risk stratification of AML patients will be difficult. This study was conducted to evaluate the prognostic value of IL-8 among AML patients with its relation to outcome. Methods: This is a cross sectional study; 42 newly diagnosed AML patients (<65 years) were investigated with determination of serum IL-8 by ELISA and followed up for 36 months. In addition, 20 sex and age matched normal volunteers were included as control. Results: In AML patients, serum IL-8 was ranging from 5 to 200 pg/mL with a mean of 76.5 pg/mL. It was significantly higher among AML patients when compared to the control (76.5 vs 32.3 pg/mL). The mean did not show any significant relationship to patients' sex or the FAB classification of AML (p>0.05). While significant higher mean was observed among poor cytogenetic risk group (110.4 pg/mL) as well as among died patients (108.8 pg/mL) and refractory patients (84.2 pg/mL). In regard to survival, among those with IL-8>40 pg/mL, the mean survival time was higher in comparison to AML patients with IL-8 ≤ 40 pg/mL (34.6 months vs 26.3 months). Conclusion: This study concluded that serum IL-8 concentration at presentation of AML patients is high and it could be used as a marker for risk stratification for AML patients.

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“…In India male: female ratio was 2.5:1 [4]. In Pakistan male: female ratio was 1.5:1, 1.4:1, and 1.3:1 [5][6][7]. In other study male: female ratio was 1.8:1 [8].…”

Section: Introductionmentioning

confidence: 99%

“…In other study male: female ratio was 1.8:1 [8]. Age distribution is different among different population, where the median age of patients was 71 years in USA, while the median age of patients was 48.5 ±20 in Saudi Arabia, and 34.5 years Pakistan [9][10][11]. Acute leukemia is most commonly presented with one or more of CBC abnormalities including anemia, thrombocytopenia and white blood cells count abnormalities [12].…”

Section: Introductionmentioning

confidence: 99%

What Do All Autoimmune Diseases Have in Common?

2021

JCEI

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Objective: To study the demographic characters and diagnostic tools of acute leukemia among adults in Benghazi/ Libya. Patients and Method: A retrospective cross sectional analysis of 54 cases of AML and ALL was conducted at hematology department at Benghazi medical center (BMC) from January 2013 to December 2014. Demographic data, Complete Blood Picture (CBC), Peripheral Blood Film (PBF), Bone Marrow Aspiration (BMA), immunophenotyping as well as cytogenetic if applicable were evaluated. Result: Forty-two (77.8%) were diagnosed as AML and twelve (22.2%) as ALL. The median age for diagnosis of AML was 43 years. with male to female ratio 1.3:1 while for ALL the median age was 20 years, and male to female ratio was 2:1. Anemia was noted in (90.5%) and (100%) for AML and ALL, respectively. Thrombocytopenia was detected in (83%) for both types. Almost half of AML patients (47%) and (41%) of ALL cases presented with leukocytosis. Blasts were detected in more than two third (74%) of PBF of AML and (75%) in ALL patients. CD13 and CD33 and cyMPO were the most common positive myeloid presenting antigens. However, in ALL B-lymphoid markers CD10 and CD19 were the major positive antigens. Conclusion: AML was most common than ALL in adults, AML was common in middle age while ALL in young age group. Hematology departments require urgent improvement of diagnostic services in Libya in order to ensure good clinical management.

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Acute Myeloid Leukemia: Clinical Spectrum of 125 Patients

Cited by 5 publications

References 19 publications

Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Interleukin-8 as a Surrogate Marker in Risk Stratification of Patients with Acute Myeloid Leukemia

What Do All Autoimmune Diseases Have in Common?

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