“…Given that focal CAS is caused by local hyperreactivity to a generalized constrictor stimulus in mild atherosclerosis, the researchers thought that the pathophysiology of diffuse CAS is limited to atherosclerotic lesions (Kitano et al, 2018). Occasionally, diffuse CAS can cause serious complications, such as cardiogenic shock, malignant arrhythmia (i.e., ventricular arrhythmias), and even death (Shimizu et al, 2018;Zhang et al, 2016). Nitroglycerin should be taken sublingually during each attack to reduce the duration of symptoms and ischemia.…”