Acute myocardial infarction in patients with normal coronary arteries after acute ethanol intoxication

Abstract

Summary:Three cases are presented where acute myocardial infarction occurred in young individuals after an episode of heavy alcohol intake. Subsequent coronary arteriograms demonstrated normal coronary arteries. Several mechanisms by which acute ethanol intoxication might precipitate myocardial infarction are discussed. To our knowledge, no similar cases have been reported.

Mean platelet volume is elevated in patients with myocardial infarction with normal coronary arteries, as in patients with myocardial infarction with obstructive coronary artery disease

“…MPV was measured in a blood sample collected in dipotassium EDTA tubes with an automatic blood counter (Beckman Coulter). For further determination of glucose, creatinine and lipid profi les, the second blood sample was drawn after a fasting period coronary trauma, coronary vasospasm and coronary thrombosis [5][6][7][8][9][10][11][12]. However, when specifi c aetiologies such as these are sought systematically, aetiology of MINC can be detected in only one-third of cases [22].…”

“…Various mechanisms have been hypothesized in myocardial infarction with normal coronary arteries (MINC), including transient occlusion of the infarct-related artery owing to platelet hyperactivity and thrombosis [5][6][7], coronary artery spasm [8], toxic conditions [9][10][11] and coronary embolization [12].…”

Trauma associated with acute myocardial infarction in a multi-state hospitalized population

“…AMI has been recognized as a complication of cocaine abuse among young men and ethanol overdose may cause coronary vasospasm and death [33][34][35][36]. Cocaine use and alcohol use, both related to risk for injury [37][38][39], were entered as categorical variables.…”

Role of Vasospasm in Acute Coronary Syndrome-Insights From Ergonovine Stress Echocardiography-

“…Two patients had positive results after repeated tests. These findings suggest that specific provocative situations, such as high sympathetic activity, 12 heavy alcohol drinking 13 or local inflammation 14 could cause acute chest pain in patients with no previous history of variant angina or with a history of variant angina with low clinical activity. Another explanation could be the residual effect of vasodilatory drugs administered during the acute stages of MI.…”