Mean platelet volume is elevated in patients with myocardial infarction with normal coronary arteries, as in patients with myocardial infarction with obstructive coronary artery disease

Abstract

Although the majority of cases of acute myocardial infarction are caused by atherosclerotic coronary artery disease (CAD), it can also occur in people with normal coronary arteries. One of the possible mechanisms causing myocardial infarction with normal coronary arteries (MINC) is transient occlusion of the infarct-related artery owing to platelet hyperactivity and thrombosis. Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with unstable angina and myocardial infarction in the setting of obstructive CAD. However, the value of MPV in patients with MINC is not known. The aim of this study was to assess the MPV in patients with MINC. We retrospectively studied 47 patients with MINC, 63 patients with myocardial infarction resulting from single coronary artery disease (MISC) and 55 control subjects. MPV values were recorded in all study patients and control subjects. The MPV values of patients with MINC and MISC were significantly higher than those of the control group (9.1+/-1.8 and 9.4+/-1.0 versus 8.3+/-1.4 fl; p<0.05 and p<0.001, respectively). There were no significant differences in MPV values between the MINC and MISC groups. We show for the first time that MPV is significantly higher in patients with MINC compared with control subjects. Concurring with previous studies, we also show that MPV is significantly higher in patients with MISC compared to control subjects.

Platelet volume indices in acute coronary syndrome - a case control study

“…19,[21][22][23] In the present study also, MPV was statistically significantly increased in STEMI and UA compared to the controls, hence the current is in accordance with all above studies. Yaghoubi A et al 19 study showed that difference in MPV between MI patients and UA patients was not significant, like Khandekar et al in India.…”

Mean platelet volume and its prognostic value in acute coronary syndrome complicated by cardiogenic shock

“…Likewise, MPV is higher in MI with normal coronary arteries compared to control subjects [16]. The important clinical implication of MPV is its predictive value of coronary angioplasty effectiveness.…”

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

“…28 In hypertensive patients, there is a compelling evidence on the role of platelet activation in hypertensive thrombotic complications including stroke 32 and myocardial infarction. 7 Increased platelet activation might be related to increased vascular thrombotic risk in prehypertension. However, in our study, increased MPV was negatively correlated with plasma total cholesterol, and low-density lipoprotein cholesterol was negatively correlated with minimal changes in absolute numbers.…”

“…6 MPV is an important biological variable that is drawing increased interest as an independent risk factor for myocardial infarction. 7 The literature on the association between MPV and stroke is inconsistent 8,9 and may also relate to the use of different methods to assess MPV and the variable time points used for MPV measurement after stroke onset. 10 Moreover, emerging evidence has shown that known cardiovascular risk factors, such as smoking, 11 diabetes mellitus, 12 obesity 13 and hypertension, 14,15 are associated with MPV.…”