Acute Myocardial Ischemia: Significance of Plasma-Transaminase Activity

Goble, Alan J.; O'Brien, Elizabeth

doi:10.1016/s0140-6736(58)92305-5

Cited by 21 publications

(4 citation statements)

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“…Wood (1961) suggested that though coronary arterial occlusion had occurred in these cases, myocardial infarction was not the inevitable sequel, especially if treatment was initiated at an early stage of the illness. However, Goble and O'Brien (1958) found fluctuating levels of serum aspartate aminotransferase in patients with acute coronary insufficiency when daily measurements of this enzyme were made over a period of 10 days, and they concluded that their patients were undergoing diffuse myocardial necrosis during that time. Although the serum aspartate aminotransferase and lactate dehydrogenase levels remained unchanged and within normal limits in the patients whom we studied, it is probable that those showing raised y-glutamyl transpeptidase levels had had one or more episodes of myocardial necrosis sometime before admission to hospital.…”

Section: Discussionmentioning

confidence: 99%

Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.

Hedworth-Whitty¹,

Whitfield²,

Richardson³

1967

Heart

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Section: Discussionmentioning

confidence: 99%

Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.

Hedworth-Whitty¹,

Whitfield²,

Richardson³

1967

Heart

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“…In patients with prolonged cardiac pain but without other clinical or ECG evidence of infarction (which is presumed not to occur), increased enzyme activity in serum is observed in more than 10% of cases (Goble and O'Brien, 1958;Agress, 1959;Resnik, 1962). The levels generally remain less than twice the upper limit of normal and when LD is elevated it is the LD1 fraction that is increased.…”

Section: Acute Coronary Insufficiencymentioning

confidence: 99%

Enzyme assays in diseases of the heart and skeletal muscle.

Rosalki¹

1970

Journal of Clinical Pathology

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“…The range for GO-Tin eleven patients was 40-290 units and GP-T 4-65 units. In patients with known ischaemic heart disease, however, normal enzyme values are reassuring, but do not necessarily exclude minor cardiac muscle damage (Goble and O'Brien, 1958).…”

Section: Hepatitismentioning

confidence: 99%

The Serum Transaminases in Heart and Liver Disease

Alldis

1962

Proceedings of the Association of Clinical Biochemists

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21aqueous solvents are used on ion-exchange papers simplifies the requirements of an apparatus and virtually eliminates some sources of irreproducible results on a conventional paper chromatogram.Ion-exchange papers may be converted into different counter ionic forms by means of a descending chromatographic wash with a suitable aqueous solution followed by a water wash and drying. Such a procedure leads to the use of a .. dry method" of development. Alternatively, a .. wet method" of development may be more suitable in which case the final water wash is omitted and after careful blotting or otherwise draining of the paper the mixture to be separated is applied directly to the wet paper for development.The stationary phase in conventional paper chromatography is regarded as the cellulose itself which makes this phase virtually invariable chemically. Variations in performance on such a chromatogram occur mainly via changes in the developing solvent system. In ion-exchange paper chromatography the variety of functional groups and the matrices to which these are attached confer wide powers of control on the stationary phase with a smaller emphasis being placed on the mobile phase.A comparison of separations of amino acids on various ion-exchange papers show wide changes in relative rates of movement of individual components of a mixture as the functional group changes from anionic to cationic and the exchanger matrix from hydrophilic cellulose to hydrophobic resin. The importance of the effect of the exchanger matrix is emphasised in the reversal of sequence within certain groups of amino acids on changing the exchanger matrix while the functional groups remains virtually the same. The direction of the matrix interaction effect is such that it allows a higher resolution of amino acids on a cation exchange resin compared to a cation exchange cellulose and on an anion exchange cellulose compared to an anion exchange resin.A new two-dimensional method combining ion-exchange separations in one direction with .. partition type" separation in the second allows an increased potential resolution of complex amino acid mixtures on ion-exchange papers relative to conventional papers on which two different solvent systems are combined. An order of increasing resolving powers of the papers is conventional < cellulose phosphate < DEAE cellulose< sulphonated polystyrene resin loaded.

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Acute Myocardial Ischemia: Significance of Plasma-Transaminase Activity

Cited by 21 publications

References 0 publications

Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.

Serum gamma-glutamyl transpeptidase activity in myocardial ischaemia.

Enzyme assays in diseases of the heart and skeletal muscle.

The Serum Transaminases in Heart and Liver Disease

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