Acute Necrotizing Eosinophilic Myocarditis in a Patient Taking Garcinia Cambogia Extract Successfully Treated With High-Dose Corticosteroids

Allen, Scott F.; Godley, Robert W.; Evron, Joshua M.; Heider, Amer; Nicklas, John M.; Thomas, Michael P.

doi:10.1016/j.cjca.2014.08.025

Cited by 23 publications

(12 citation statements)

References 5 publications

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“…Acute necrotizing eosinophilic myocarditis resulted in heart failure requiring extracorporeal membrane oxygenation. 131 Further, sub-chronic consumption of G. cambogia along with selective serotonin reuptake inhibitors namely escitalopram and sertaline for 2-3 months, a 35-year-old woman developed serotonin toxicity. 132 A week after the consumption of G. cambogia, the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and ferritin of a 42-year-old female were 1277 U/L (normal range: 7-40 U/L), 2792 U/L (normal range: 5-50 U/L), 283 U/L (normal range: 40-150 U/L) and 12,198 mcg/L (normal range: 11-307 mcg/L) respectively.…”

Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

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The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

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Section: Resultsmentioning

confidence: 99%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

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“…Corey et al also reported a case of acute liver failure secondary to use of GC requiring liver transplantation [8]. There have also been reports of acute necrotizing eosinophilic myocarditis, rhabdomyolysis, serotonin toxicity, and nephropathy secondary to use GC [9-12].…”

Section: Discussionmentioning

confidence: 99%

Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia

Iqbal

Anwar

Siddiqui

et al. 2019

Cureus

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Due to the global epidemic of obesity, weight loss and appetite suppressant herbal products are quite popular. As these medications are not United States Food and Drug Administration-approved and are regulated as dietary supplements, little evidence exists regarding their safety. This case discusses an 82-year-old man with the past medical history of obesity who presented to the emergency department with abdominal pain in the epigastric region. His serum lipase was elevated, and an abdominal computed tomography revealed acute pancreatitis (AP). He reported two episodes of AP in the past. He denied any alcohol use and reported no recent changes in his medications. He reported taking Garcinia cambogia (GC) recently as an appetite suppressant. Due to prior cholecystectomy, no alcohol abuse, no recent changes in medications and recent use of GC, a likely etiology of AP was thought to be secondary to the use of GC. He was treated with bowel rest and intravenous fluid hydration with significant improvement in his symptoms. He was advised to avoid GC in the future. Clinicians should be vigilant in evaluating their patients with AP and should get a meticulous history regarding their use of over-the-counter medications and herbal products.

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“…The potential side effects of Garcinia cambodia may include hepatotoxicity and rhabdomyolysis, but are not well confirmed, as they were described in patients taking multicomponent weight-loss herbal supplements [16]. However, the temporal relationship of the Garcinia cambodia administration with acute necrotizing eosinophilic myocarditis and the lack of any other precipitating factors was recently described [17]. The association of Giardiasis (hypereosinophilia caused by parasitic infection) and myocarditis is also known [18].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic myocarditis: Gardia lamblia infestation and Garcinia cambogia. Coincidence or causality?

Dzierwa

Rubiś

Rudnicka-Sosin

et al. 2016

Journal of Rare Cardiovascular Diseases

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Eosinophilic myocarditis is a rare form of myocardial inflammation that may lead to heart failure and death, if left untreated. A previously healthy 26-year-old man was admitted to the department with chest pain and dyspnoea, that started two days before. Few days prior to the onset of symptoms he started to take weight-loss supplement with Garcinia cambogia. On laboratory tests myocardial necrosis markers were positive and blood hypereosinophilia was noted. Left ventricular ejection fraction was slightly decreased to 45% with regional wall motion abnormalities and significantly thickened left ventricle walls. Coronary angiography did not show any abnormalities. Endomyocardial biopsy revealed eosinophil infiltration of the myocardium. Stool cultures were positive for Giardia lamblia. The patient initially received standard heart failure therapy and then due to eosinophil infiltration of the myocardium, systemic steroids and antiparasitic treatment were added. His general condition and ejection fraction improved after a week and he was discharged home on standard heart failure treatment and prednisone. In the setting of acute coronary syndrome symptoms in patients without atherosclerotic lesions and decreased ejection fraction myocarditis should be suspected. Blood hypereosinophilia may raise suspicion of the eosinophilic myocarditis. The proper diagnosis should be supported by endomyocardial biopsy results as it plays key role in the initiation of steroid therapy which leads to heart failure symptoms relieve and improvement of left ventricle function. JRCD 2016; 2 (7): 1-1

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Acute Necrotizing Eosinophilic Myocarditis in a Patient Taking Garcinia Cambogia Extract Successfully Treated With High-Dose Corticosteroids

Cited by 23 publications

References 5 publications

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Acute Pancreatitis Secondary to Use of Appetite Suppressant: Garcinia cambogia

Eosinophilic myocarditis: Gardia lamblia infestation and Garcinia cambogia. Coincidence or causality?

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