Acute Nontraumatic Hemoabdomen in the Dog: A Retrospective Analysis of 39 Cases (1987–2001)

Pintar, Jason; Breitschwerdt, Edward B.; Hardie, Elizabeth M.; Spaulding, Kathy A.

doi:10.5326/0390518

Cited by 102 publications

(122 citation statements)

References 12 publications

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“…Many owners will opt for emergency surgical removal of the spleen to save the dog's life through the crisis, despite the fact that the long-term prognosis for the dog could be very poor since 70% of dogs with splenic masses presenting with nontraumatic hemoabdomen do indeed have hemangiosarcoma as the underlying pathology [27]. Despite the fact that metastatic disease may not be identified at the time of splenectomy, rapid and widespread metastatic disease to the liver, omentum and/or mesentery, will typically lead to the development of a life-ending hemorrhagic shock crisis within 3 months of the splenectomy (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma

Brown

Reetz

2012

Evidence-Based Complementary and Alternative Medicine

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The 2008 World Health Organization World Cancer Report describes global cancer incidence soaring with many patients living in countries that lack resources for cancer control. Alternative treatment strategies that can reduce the global disease burden at manageable costs must be developed. Polysaccharopeptide (PSP) is the bioactive agent from the mushroom Coriolus versicolor. Studies indicate PSP has in vitro antitumor activities and inhibits the growth of induced tumors in animal models. Clear evidence of clinically relevant benefits of PSP in cancer patients, however, is lacking. The investment of resources required to complete large-scale, randomized controlled trials of PSP in cancer patients is more easily justified if antitumor and survival benefits are documented in a complex animal model of a naturally occurring cancer that parallels human disease. Because of its high metastatic rate and vascular origin, canine hemangiosarcoma is used for investigations in antimetastatic and antiangiogenic therapies. In this double-blind randomized multidose pilot study, high-dose PSP significantly delayed the progression of metastases and afforded the longest survival times reported in canine hemangiosarcoma. These data suggest that, for those cancer patients for whom advanced treatments are not accessible, PSP as a single agent might offer significant improvements in morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma

Brown

Reetz

2012

Evidence-Based Complementary and Alternative Medicine

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“…4 Unlike dogs, the cause of hemoperitoneum in cats was nearly equally distributed between neoplastic and nonneoplastic diseases. 4 Unlike dogs, the cause of hemoperitoneum in cats was nearly equally distributed between neoplastic and nonneoplastic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…4 Unlike dogs, the cause of hemoperitoneum in cats was nearly equally distributed between neoplastic and nonneoplastic diseases. 4 In cats, lymphoma is often found intraperitoneally, 10 but rarely results in rupture and subsequent bleeding of an abdominal organ. In both species, the spleen is the organ most likely to develop neoplasia that results in rupture.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous hemoperitoneum in cats: 65 cases (1994–2006)

Culp

Weisse

Kellogg

et al. 2010

javma

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“…This is comparable to the reported incidence of hemoperitoneum in retroperitoneal HSA (11%), 18 but varies considerably from the reported 40-60% incidence of hemoabdomen in dogs with splenic HSA. 22,23 This difference may indicate a less aggressive disease process associated with renal HSA; conversely, it may simply be related to the retroperitoneal anatomy of the kidneys, which provides less opportunity for direct hemorrhage into the peritoneal cavity. If anatomic separation was responsible for the lack of hemoperitoneum in the majority of cases, it is reasonable to expect that retroperitoneal hemorrhage may still be noted; however, no ultrasonographic evidence of retroperitoneal hemorrhage was noted in any of the 9 cases that had ultrasound performed.…”

Section: Discussionmentioning

confidence: 99%

Comparative Aspects and Clinical Outcomes of Canine Renal Hemangiosarcoma

Locke

Barber

2006

Veterinary Internal Medicne

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Background: Hemangiosarcoma (HSA) is a common solid tumor of the spleen, heart, and skin of dogs. Renal HSA represents an uncommon anatomic variant, with little reported about its biologic behavior and clinical outcome. Hypothesis: That renal HSA is associated with longer survival than other visceral forms of HSA. Animals: 14 dogs with renal HSA. Methods: Medical records from 1999 to 2004 were searched for dogs with histopathologically confirmed renal HSA, and data relevant to clinical signs, treatments, and outcomes were abstracted. Results: Clinical signs were nonspecific, and the median duration of clinical signs before diagnosis was 60 days. Two dogs presented in cardiovascular collapse secondary to hemoperitoneum. Common hematologic and biochemical abnormalities were anemia (9/14), hematuria (7/14), and proteinuria (7/14). One dog had pulmonary metastasis at diagnosis. All dogs had evidence of a renal mass visualized by abdominal radiography (14/14), ultrasound (9/14), or both. All dogs underwent nephrectomy, and 4/14 dogs also received adjunctive chemotherapy. Median survival time of all dogs was 278 days (range 0–1,005 days), and dogs with hemoperitoneum had significantly shorter survival times than dogs without hemoperitoneum (62 days versus 286 days, P < .001). Conclusions and Clinical Importance: These results indicate that hemoperitoneum and distant metastasis at diagnosis appear to occur less frequently in dogs with renal HSA compared with other visceral forms of HSA. Furthermore, dogs with renal HSA have protracted disease progression, with improved 1 ‐year survival rates and longer median survival time compared to dogs with splenic, cardiac, and retroperitoneal HSA.

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Acute Nontraumatic Hemoabdomen in the Dog: A Retrospective Analysis of 39 Cases (1987–2001)

Cited by 102 publications

References 12 publications

Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma

Single Agent Polysaccharopeptide Delays Metastases and Improves Survival in Naturally Occurring Hemangiosarcoma

Spontaneous hemoperitoneum in cats: 65 cases (1994–2006)

Comparative Aspects and Clinical Outcomes of Canine Renal Hemangiosarcoma

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