Acute oral toxicity evaluation of extracts of Hydrocotyle sibthorpioides in wister albino rats as per OECD 425 TG

Hazarika, Iswar; Geetha, K; Sundari, P. Sivakami; Madhu, Divya

doi:10.1016/j.toxrep.2019.04.001

Cited by 26 publications

(25 citation statements)

References 15 publications

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“…So, Dunaliella salina powdered will preserve kidney function through normalization of urea and creatinine levels. This may be linked to the antioxidant properties of Dunaliella; since ROS may be implicated in the Glomerular Filtration Rate (GFR) impaired [[20], [21], [22]]. The increase in Hb level, which detected in the present study may be attributed to the B-carotene is considered as a precursor of vitamin A and a single oxygen quencher, so could affect the immune system through both pathways of antioxidant and retinoid [23].…”

Section: Discussionmentioning

confidence: 80%

Toxicity assessment of the green Dunaliella salina microalgae

2019

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Section: Discussionmentioning

confidence: 80%

Toxicity assessment of the green Dunaliella salina microalgae

2019

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“…Measurement of haematological parameters plays is crucial in assessing the physiological and pathological status in man and animals. Thus alteration in normal values of these parameters could occur following ingestion of some toxic plants [ 28 , 29 ]. In the sub-chronic study for 28 days, no significant alteration was observed in all the haematological parameters of the treated rats when compared with the control group except for group treated with the fraction of leaf ethyl acetate of the plant at 750 mg/kg that had significantly (P < 0.05) higher values of neutrophil, basophil, eosinophil, monocyte and lymphocyte compares to control group rats.…”

Section: Discussionmentioning

confidence: 99%

Acute and sub-chronic toxicity evaluation of the crude methanolic extract of Diospyros mespiliformis hochst ex a. Dc (ebenaceae) and its fractions

et al. 2020

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“…Manuscript to be reviewed transaminase serum enzymes ALT & AST start releasing from the cytosol and translocate into the bloodstream, leading to mild or severe liver injury (Figueredo et al 2018;Hazarika et al 2019;Ramaiah 2011). In our study, LA did not elevate these transaminase enzymes, considering nontoxic nature of LA at different dose levels.…”

Section: Discussionmentioning

confidence: 49%

Peer Review #1 of "Food additive “lauric acid” possess non-toxic profile on biochemical, haematological and histopathological studies in female Sprague Dawley (SD) rats (v0.1)"

Sari¹

2020

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Background: Lauric acid (LA), a common constituent of coconut oil is used as food additives and supplements in various formulations. Despite various potential pharmacological properties, no scientific evidence on its dose-related toxicity and safety is available till date. Objective: The current study was conducted to evaluate acute oral toxicity of LA on normal rats. Methods: Study was conducted in accordance with the Organization for Economic Cooperation and Development guidelines (OECD 423) with slight modifications. LA was administered orally to female Sprague Dawley (SD) rats (n = 6/group) at a single dose of 300 and 2000 mg/kg body weight respectively, while normal control received vehicle only. Animals from all the three groups were monitored for any behavioural and toxicological changes and mortality for two weeks. Food and fluid consumption, body weight was monitored on daily basis. At the end (on day 15 th) of the experimental period, blood was collected for haematological and biochemical analysis. Further, all the animals were euthanized, and internal organs were harvested for histopathological investigation using four different stainings; haematoxylin and eosin, Masson trichrome, Periodic Acid Schiff and Picro Sirius Red for gross pathology through microscopical observation. Results: Study result showed no LA treatment-related mortality and morbidity at two different dosages. Daily food and water consumption, body weight, relative organ weight, haematological, and biochemical analysis were observed to be normal with no severe alterations to the internal tissues. Conclusion: Current finding suggests that single oral administration of LA, even up to 2000 mg/kg body weight did not exhibit any signs of toxicity in SD rats, thus, safe to be used on disease model in animals.

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Acute oral toxicity evaluation of extracts of Hydrocotyle sibthorpioides in wister albino rats as per OECD 425 TG

Abstract: Graphical abstract

Cited by 26 publications

References 15 publications

Toxicity assessment of the green Dunaliella salina microalgae

Toxicity assessment of the green Dunaliella salina microalgae

Acute and sub-chronic toxicity evaluation of the crude methanolic extract of Diospyros mespiliformis hochst ex a. Dc (ebenaceae) and its fractions

Peer Review #1 of "Food additive “lauric acid” possess non-toxic profile on biochemical, haematological and histopathological studies in female Sprague Dawley (SD) rats (v0.1)"

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