Acute oral toxicity of cottonseed oil

Boyd, Eldon M.; Boulanger, Michèle

doi:10.1016/0041-008x(69)90004-0

Cited by 16 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The non significant change in these organs weight is supported by the findings of Nesaretnam et al (1992) who reported that male sprague dawley rats were fed semipurified diets containing 20% C.O. for 15 weeks showed no difference in their organs weight, whereas the study of Boyd and Boulanger, (1969) showed that male rats treated with 70-80 ml/kg C.O. caused loss in dry organ weight.…”

Section: Absolute and Relative Weight Of Liver And Kidneymentioning

confidence: 61%

See 1 more Smart Citation

The Study of Body Weight, Haematological and Serum Biochemical Parameters, Liver and Kidney Texture in Rats Fed Corn Oil

2017

ZJPAS

View full text Add to dashboard Cite

The present study aimed to investigate the effect of Afia corn oil (C.O.) 0.3 ml/rat on animals body weight (B.W.), foodintake, organs weight of liver, and kidney, some haematological and serum biochemical parameters, liver and kidney sections, orally by gavage in adult male rats for 4 weeks. Serum total cholesterol, Serum triglyceride (TG) and Low density lipoprotein (LDL) were decreased significantly from control group. While non significant change occurred in animals B.W., foodintake, organs weight, haematological parameters, and high density lipoprotein (HDL), also histological sections of liver and kidney were similar to those of control group. The results of the present study indicating that Afia C.O. offering health benefits through decreasing of cholesterol, TG, and LDL concentrations.

show abstract

Section: Absolute and Relative Weight Of Liver And Kidneymentioning

confidence: 61%

“…It has been suggested that male albino rats were administrated by acute oral C.O. 70-80 ml/kg caused capillary venous congestion, necrosis and many droplet in at the proximal and distal tubules (Boyd and Boulanger, 1969). Furthermore it has been reported that female rats were administered by 10ml/kg C.O.…”

Section: Histological Texture Of Liver and Kidneymentioning

confidence: 99%

The Study of Body Weight, Haematological and Serum Biochemical Parameters, Liver and Kidney Texture in Rats Fed Corn Oil

2017

ZJPAS

View full text Add to dashboard Cite

show abstract

“…All of the foods studied were found capable of producing le thal reactions in albino rats when given orally in a sufficiently high dos age. The types of clinicopathologic syndromes of toxicity to foods have been reviewed by Boyd, Boulanger and Carsky [1969].…”

Section: Discussionmentioning

confidence: 99%

Benzylpenicillin Toxicity in Albino Rats Fed Synthetic High Starch Versus High Sugar Diets

Boyd

Dobos

Taylor³

1970

Chemotherapy

Self Cite

View full text Add to dashboard Cite

The studies reported in this paper were undertaken to investigate the hypothesis of Boyd, Covert and Pitman (Chemotherapia 11: 320, 1966) that the augmented toxicity of benzylpenicillin given orally to albino rates fed a synthetic pyridoxine-deficient diet was due to the presence of large amounts of sucrose in that diet. Benzylpenicillin potassium was given orally in a dose of 5.34 g/kg/day to young adult albino rats fed (a) a diet containing 22 % of casein, 69.4 % of sucrose, 4.0 % of salt mix, 2 % of hydrogenated vegetable oil, 2 % of cod liver oil, 0.5 % of wheat germ oil and adequate vitamin supplements (except pyridoxine) or (b) the same diet but with 69.4 % of cornstarch in place of the 69.4 % sucrose. The death rate and clinicopathologic signs of toxicity to benzylpenicillin were significantly greater in rats fed diet (a) than in those fed diet (b). It was concluded that the fulminating toxicity syndrome seen in animals fed diet (a) was due to a combination of the toxicity of subtoxic amounts of dietary sucrose and sublethal amounts of administered benzylpenicillin over the interval studied.

show abstract

“…Cottonseed (Gossypium) Oil. Boyd and Boulanger (1969) reported an intragastric LD 50 of 275 § 22 ml/kg in young male albino rats. The dose represented a 4-day cumulative dose, as an earlier study noted that amounts >70 ml/kg were immediately evacuated through the anus.…”

Section: Acutementioning

confidence: 98%

Final Report on the Safety Assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride

2001

Int J Toxicol

View full text Add to dashboard Cite

Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride are cosmetic ingredients derived from Cottonseed Oil and used as skin-conditioning agents and surfactants. Non-oils known to be toxic that may be found in cottonseed oils include gossypol, aflatoxin, and cyclopropenoid fatty acids (CPFA). Toxic heavy metal and/or polychlorinated biphenyl (PCB) or other pesticide contamination is also possible. Cottonseed Oil was nontoxic in acute oral toxicity studies in rats. In a short-term study, rabbits that had been fed 2% Cottonseed Oil for 7 weeks had significantly lower blood chemistry parameters (compared to wheat bran controls) and significantly more stored hepatic vitamin A (compared to rabbits fed other fats). Cottonseed Oil controls used as vehicles in two parenteral studies produced negative results. Hydrogenated Cottonseed Oil tested in formulation did not produce dermal or ocular irritation in rabbits. An oral-dose reproductive study tested up to 30% Cottonseed Oil (with 1% CPFAs) and reported no adverse effects on sexual maturity and reproductive performance of the F0 generation; changes were noted in the F1 generation but reproductive capacity was not altered. Parenteral-dose reproductive studies reported no adverse effects. Cottonseed Oil was not mutagenic. Cottonseed Oil did not induce aberrant crypt foci when given orally to mice, but in other studies, it increased the incidence of spontaneous mammary tumors in rats and mice. Mice fed 20% Hydrogenated Cottonseed Oil during induction and promotion of photocarcinogenesis had significantly lower tumor incidence compared to mice fed 20 % sunflower oil. Hydrogenated Cottonseed Oil in formulation (up to 21 %) was neither an irritant nor sensitizer in clinical studies. Limited clinical data indicated that Cottonseed Oil does not contain allergic protein. Based on the available data, it was concluded that these ingredients may be used safely in cosmetic formulations if established limits on gossypol, heavy metals, and pesticide concentrations are not exceeded.

show abstract

Acute oral toxicity of cottonseed oil

Cited by 16 publications

References 7 publications

The Study of Body Weight, Haematological and Serum Biochemical Parameters, Liver and Kidney Texture in Rats Fed Corn Oil

The Study of Body Weight, Haematological and Serum Biochemical Parameters, Liver and Kidney Texture in Rats Fed Corn Oil

Benzylpenicillin Toxicity in Albino Rats Fed Synthetic High Starch Versus High Sugar Diets

Final Report on the Safety Assessment of Hydrogenated Cottonseed Oil, Cottonseed (Gossypium) Oil, Cottonseed Acid, Cottonseed Glyceride, and Hydrogenated Cottonseed Glyceride

Contact Info

Product

Resources

About