Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats

Balijepalli, Madhu Katyayani; Suppaiah, Velan; Chin, An‐me; Buru, Ayuba Sunday; Sagineedu, Sreenivasa Rao; Pichika, Mallikarjuna Rao

doi:10.4103/0974-8490.147197

Cited by 26 publications

(14 citation statements)

References 19 publications

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“…The same way Peristrophe bivalvis extracts with antivenom potential to Naja kaouthia and Trimeresurus albolabris, did not show toxic signs in rats (27) The toxicity of the seed extract of various species of Swietenia were previously described, in a recent study of acute oral toxicity of the seed extract from Swietenia mahagoni in a murine model, lesions suggestive of organ toxicity at doses of 25, 200 2000, 5000 mg/kg were not observed (28). In another study which the acute oral toxicity of seed extract from Swietenia macrophylla in rats at doses of 2000 mg/kg was evaluated, the results showed that seeds did not produce significant differences in weight, food and water intake, biochemical and hematological parameters, or macroscopic and histopathological changes in the organs of the treated animals compared with controls (6).…”

Section: Discussionmentioning

confidence: 90%

“…Its seeds have many uses, such as in the traditional treatment of hypertension, diabetes and to relieve pain in Malaysia, to treat leishmaniosis and to induce abortion in Bolivia, as well as for the treatment of diabetes, hypertension and malaria in Indonesia. In addition, its bark is used as an astringent for wounds and occasionally for sun tanning (2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

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ACUTE ORAL TOXICITY FROM A FRACTION RICH IN PHENOLIC COMPOUNDS FROM THE LEAF EXTRACT OF Swietenia macrophylla KING IN A MURINE MODEL

Henao-Duque

Rodríguez

Pereañez

et al. 2017

Vitae

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Background: The mahogany tree (Swietenia macrophylla King) is widely used in traditional medicine, especially its seeds, which are used in Malaysia, Indonesia and some countries of South America. Recently an active fraction of the leaf ethanolic extract (labelled "Sm13-16,23"), showed promising results against some toxins of South American pit vipers. Objectives: In this study the aim was to evaluate the acute oral toxicity of fraction Sm13-16,23 from the leaf ethanolic extract, using Swiss Webster mice. Methods: Fraction Sm13-16,23 was administered orally in a single dose to 2000 mg/kg and 300 mg/kg, clinical follow-up for 14 days was performed and then euthanasia, necropsy and histopathology of organs were performed. Results: Overall, there were not deaths recorded during the study period. Further not signs of toxicity in doses of 300mg/kg were observed, but at doses of 2000 mg/kg, histopathological lesions in the liver, as karyomegaly and binucleation were observed. Conclusions: Fraction Sm13-16, 23 does not produce toxicity lesion at doses of 300mg/kg, indicating that the acute oral toxicity risk is low.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

ACUTE ORAL TOXICITY FROM A FRACTION RICH IN PHENOLIC COMPOUNDS FROM THE LEAF EXTRACT OF Swietenia macrophylla KING IN A MURINE MODEL

Henao-Duque

Rodríguez

Pereañez

et al. 2017

Vitae

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“…The seeds are used to treat diabetes and hypertension. In 2015, Balijepalli [ 22 ] evaluated the safety of SMS in Sprague-Dawley (SD) rats. Their conclusion was that the rat dose of 2 g/kg bw, which is equivalent to the human dose of 325 mg/kg bw and well below the common amount that is consumed by people, did not exhibits any signs of toxicity in rats.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Herb-induced autoimmune-like hepatitis associated with Xiang-tian-guo (Swietenia macrophylla seeds)

et al. 2021

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Rationale: Drug-induced liver injury (DILI) has a relatively low incidence, whereas the incidence of herb-induced liver injury (HILI) is still under investigation. As a special type of DILI, the diagnosis of drug-induced autoimmune-like hepatitis presents a persistent challenge, because this condition has partial characteristics of both DILI and autoimmune hepatitis (AIH), such as a certain history of medication use and histology that similar is to AIH. Thus, the differential diagnosis between DILI and AIH can be confusing. Patient concerns: A 67-year-old woman taking xiang-tian-guo for 6 months was admitted to our hospital with a complaint of experiencing jaundice for 2 weeks. Diagnosis: A liver biopsy exhibited interface inflammation, foam cells, and “rosette” -like hepatocytes. She was diagnosed with herb-induced liver injury (hepatocellular and acute), a RUCAM score of 7 (probable), a severity for grade 4 liver injury, and accompanied autoimmune-like changes. Interventions: The patient was instructed to cease the administration of suspicious drugs. The patient also received liver protection and albumin transfusion. Outcomes: After 25 days of hospitalization, the patients aminotransferase levels returned to normal. No recurrence was observed after the administration of the treatments and a close follow-up. Lessons: We must to be vigilant about the safety of xiang-tian-guo as a herbal medicine. When faced with the difficulty of distinguishing between AIH and DILI, long-term follow-up observations for recurrence can aid clinicians in making a judgment.

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“…Histological changes in the main organs (the liver, kidney, spleen, heart, intestine, lung and brain) were graded on a scale of 0–9 based on the degree of architecture degeneration, inflammation and necrosis [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

A comparative study of the characterization of miR-155 in knockout mice

Zhang¹,

Cui²,

Li³

et al. 2017

PLoS ONE

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miR-155 is one of the most important miRNAs and plays a very important role in numerous biological processes. However, few studies have characterized this miRNA in mice under normal physiological conditions. We aimed to characterize miR-155 in vivo by using a comparative analysis. In our study, we compared miR-155 knockout (KO) mice with C57BL/6 wild type (WT) mice in order to characterize miR-155 in mice under normal physiological conditions using many evaluation methods, including a reproductive performance analysis, growth curve, ultrasonic estimation, haematological examination, and histopathological analysis. These analyses showed no significant differences between groups in the main evaluation indices. The growth and development were nearly normal for all mice and did not differ between the control and model groups. Using a comparative analysis and a summary of related studies published in recent years, we found that miR-155 was not essential for normal physiological processes in 8-week-old mice. miR-155 deficiency did not affect the development and growth of naturally ageing mice during the 42 days after birth. Thus, studying the complex biological functions of miR-155 requires the further use of KO mouse models.

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Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats

Cited by 26 publications

References 19 publications

ACUTE ORAL TOXICITY FROM A FRACTION RICH IN PHENOLIC COMPOUNDS FROM THE LEAF EXTRACT OF Swietenia macrophylla KING IN A MURINE MODEL

ACUTE ORAL TOXICITY FROM A FRACTION RICH IN PHENOLIC COMPOUNDS FROM THE LEAF EXTRACT OF Swietenia macrophylla KING IN A MURINE MODEL

Herb-induced autoimmune-like hepatitis associated with Xiang-tian-guo (Swietenia macrophylla seeds)

A comparative study of the characterization of miR-155 in knockout mice

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