Acute oral toxicity study of polyherbal formulation AV/KPC/10

Abstract

The current study was designed to study acute oral toxicity study of polyherbal formulation AV/KPC/10 (M/S Ayurvet Limited, Baddi, India) according to OECD guidelines. For new substances it is the recommended stepwise testing approach for developing scientifically sound data on the safety of the substance. Three wistar rats (2 females and 1 male) were used for the study. AV/KPC/10 in single oral dose (2000mg/kg) supplemented to all rats. The parameters like general appearance, behavior, body weight, mortality and necropsy were studied. No changes in general appearance and mortality was observed. AV/KPC/10 was found to be safe at dose of 2000mg/kg.

A critical study on the acute oral toxicity of polyherbal formulation of Rosmarinus officinalis L. AND Withania somnifera L. in wistar Albino Rats

“…In this study, we found that the body weight of all the animals increased significantly on days 8 and 15, which is consistent with the findings of [15] , who found that all the female rats treated with the polyherbal veterinary drug for 14 days saw a slight increase in body weight. Still, they could not detect any death rates or significant toxicopathological changes [18] reported that the polyherbal formulation was non-toxic despite noticing a slight increase in the body weight of all the rats used in their study.…”

“…Similar finding and noted the absence of clinical symptoms following a single oral dosage of 2 mg/kg polyherbal formulation. After a single oral dosage of 2 mg/kg Body weight of Rosmarinus officinalis, [16,18] also found no unusual symptoms or behavioral alterations. Similar study found no acute mortality at 1100 mg/kg; however, there was a rapid increase in the death rate with an additional 100 mg increment in the dose.…”

Hubungan Kuantitatif Struktur Senyawa N-(Fenilkarbamotioil)-Benzamida Dan Turunannya Terhadap Aktivitas Anti Tuberkulosis Secara in Silico

“…Parameter toksisitas ditunjukkan dengan nilai LD 50 atau Lethal dose 50 yang berarti suatu nilai yang menunjukkan besarnya dosis yang dapat menyebabkan setengah atau 50% dari hewan uji mati (Gatne, et al, 2015). Parameter LD 50 dapat diperoleh dengan menggunakan program online yaitu ProTox.…”

“…Parameter LD 50 dapat diperoleh dengan menggunakan program online yaitu ProTox. Semakin kecil nilai LD 50 yang diperoleh maka senyawa tersebut semakin toksik (Gatne, et al, 2015). Dari hasil analisis diperoleh bahwa senyawa BFKT dan 14 turunannya memiliki nilai LD 50 yaitu 2885 dan 5 turunan lainnya memiliki nilai LD50 yaitu 2850 mg/kg serta berada di kelas 5.…”