Acute pancreatitis and parotitis induced by methimazole in a patient with Graves' disease

Taguchi, Manabu; Yokota, Masafumi; Koyano, Hajime; Endo, Yuzo; Ozawa, Yasunori

doi:10.1046/j.1365-2265.1999.00888.x

Cited by 34 publications

(19 citation statements)

References 11 publications

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“…8 In all of these reports, the mechanism was not defi nitively established, but it was presumed to be of an allergic nature. Since sulfonamides have also been linked to allergic pancreatitis, it is conceivable that the TMP/SMX-induced parotitis in our patient was the byproduct of an immune response similar to the one reported by Taguchi et al 7 Th e chemical composition of sulfonamide antibiotics diff ers from that of nonantibiotic sulfonamide compounds in that the molecular structure of the antibiotics contains a primary arylamine group, which antibiotic in our patient was also the consequence of an elicited immune response. Our patient's condition began to resolve with cessation of the TMP/SMX.…”

Section: Discussionsupporting

confidence: 70%

Acute Parotitis Induced by Trimethoprim/Sulfamethoxazole

Patel

Scheiner

2011

Ear Nose Throat J

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Adverse drug reactions to the sulfonamide antibiotics are uncommon. When they do occur, they usually manifest as a rash or urticaria. Our review of the recent literature found that while sialadenitis is listed as a possible side eff ect of sulfonamide use, no actual case has ever been reported until now. We describe a case of acute bilateral parotitis that arose as a side eff ect of sulfonamide antibiotic treatment. We also examine the relevance of such pathology to the proposed mechanisms of sialadenitis, and we briefl y discuss sulfonamide-induced pancreatitis. Lastly, we review the controversy over the possibility that some adverse drug reactions may be caused by crossreactivity among diff erent classes of sulfonamides.

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Section: Discussionsupporting

confidence: 70%

Acute Parotitis Induced by Trimethoprim/Sulfamethoxazole

Patel

Scheiner

2011

Ear Nose Throat J

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“…There have been only four reports of MMI-induced acute pancreatitis since the first report in 1999 (2, 3, 4). …”

Section: Discussionmentioning

confidence: 99%

“…Although cases of acute pancreatitis after MMI with positive rechallenge have been reported previously (3), detection of this adverse event has not been emphasized due to its low incidence. However, the accumulation of reports of such cases will encourage clinicians to suspect MMI-induced acute pancreatitis and to discontinue the use of MMI when patients taking MMI complain of abdominal pain and fever.…”

Section: Discussionmentioning

confidence: 99%

“…MMI-induced acute pancreatitis is also a major side effect (1). Only four cases of acute pancreatitis after MMI treatment have been reported worldwide (2, 3, 4) since the first report in 1999 (3). In this report, we describe the clinical course, imaging and HLA typing of a case of acute pancreatitis induced by MMI in a 51-yr-old Korean male with Graves' disease and review relevant literature.…”

Section: Introductionmentioning

confidence: 99%

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Acute Pancreatitis Induced by Methimazole Treatment in a 51-Year-Old Korean Man: A Case Report

et al. 2014

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Methimazole (MMI)-induced acute pancreatitis is very rare but severe adverse reaction. A 51-yr-old male developed a high fever, chills, and abdominal pain, two weeks after commencement on MMI for the treatment of Graves' disease. There was no evidence of agranulocytosis, and fever subsided soon after stopping MMI treatment. However, 5 hr after taking an additional dose of MMI, abdominal pain and fever developed again. His symptoms, biochemical, and imaging studies were compatible with acute pancreatitis. After withdrawal of MMI, he showed clinical improvement. This is the first case of MMI-induced acute pancreatitis in Korea. Clinicians should be aware of the rare but possible MMI-induced pancreatitis in patients complaining of fever and abdominal pain.Graphical Abstract

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“…In recent reports, acute parotitis due to organophosphate intoxication has been reported, which is a rare cause of acute pancreatitis [6,7] , and recurrent simultaneous acute pancreatitis and parotitis induced by methimazole was reported in 1 patient with Graves' disease [8] .…”

Section: Introductionmentioning

confidence: 99%

Chronic Parotitis: Not Another SPINKosis

Gundling

Reitmeier

Tannapfel³

et al. 2004

Dig Dis

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Introduction: Pancreatitis and parotitis share several etiological, pathohistological and functional similarities. It arose from recent pancreatitis research that some cases of chronic pancreatitis are associated with mutations of the serine protease inhibitor, Kazal type-1 (SPINK1). We tested the hypothesis that the pancreatitis-associated N34S mutation of SPINK1 is also a risk factor for chronic parotitis. Methods: Reverse-transcriptase polymerase chain reaction was used to investigate SPINK1 transcription in the parotid gland. Forty-five blocks of formalin-fixed, paraffin wax-embedded tissues with chronic parotitis of unknown cause were analyzed for the SPINK1-N34S mutation. Results: The SPINK1 gene is transcribed in the parotid gland. Two of the 45 patients (4.4%) with chronic parotitis carried the N34S mutation heterozygously. Of 82 healthy blood donors, 3 subjects (3.7%) were identified as carrying this mutation heterozygously (p = 0.83). Conclusion: The SPINK1-N34S mutation is not associated with chronic parotitis.

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Acute pancreatitis and parotitis induced by methimazole in a patient with Graves' disease

Cited by 34 publications

References 11 publications

Acute Parotitis Induced by Trimethoprim/Sulfamethoxazole

Acute Parotitis Induced by Trimethoprim/Sulfamethoxazole

Acute Pancreatitis Induced by Methimazole Treatment in a 51-Year-Old Korean Man: A Case Report

Chronic Parotitis: Not Another SPINKosis

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