Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

Acharyya, Bhaswati C; Dutta, Monideepa; Meur, Säumen; Das, Dhritabrata; Acharyya, Saumyabrata

doi:10.1097/pg9.0000000000000150

Cited by 8 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acharya et al suggested that pancreatitis should be included in the MIS-C diagnostic criteria, due to its frequency and poor clinical course. [10] In our study, similar to the literature, we found that the rate of hospitalization in the intensive care unit is higher in the presence of acute pancreatitis.…”

Section: Discussionsupporting

confidence: 90%

“…Gastrointestinal symptoms, which were thought to be less common in the early stages of the COVID-19 pandemic, have been reported more frequently after the identification of MIS-C. [3] It is increasingly recognized that gastrointestinal symptoms and signs are the most common clinical presentation of MIS-C. [8] Cases ranging from mild gastrointestinal symptoms such as isolated nausea and vomiting to severe manifestations such as terminal ileitis, pancreatitis, and acute abdomen have been reported. [9][10][11] Our study focused on MIS-C cases with gastrointestinal system involvement and evaluated the severity of gastrointestinal involvement, clinical features, laboratory findings, and clinical outcome. In a meta-analysis in which 8 studies including a total of 440 MIS-C cases were evaluated, it was reported that the age of the cases ranged from 7 to 10 years, with a dominance of male gender 59%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pediatrik Multisistem İnflamatuvar Hastalıkta (MIS-C) Gastrointestinal Sistem Tutulumu: 47 Olgunun Tek Merkez Deneyimi

YÜCEL

Metin

2023

Journal of Contemporary Medicine

View full text Add to dashboard Cite

Abstract Backgraound/Aims: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory syndrome which was newly described during the coronavirus disease 2019 (COVID-19) pandemic in children and characterized by fever, inflammation, multiorgan dysfunction. One of the major clinical presentation is gastrointestinal system involvement. The aim of the study is to evaluate the clinical course and outcome according to the severity of gastrointestinal presentation, focusing on MIS-C cases with gastrointestinal system involvement. Methods: We performed a retrospective study of 47 MIS-C patients with gastrointestinal involvement in our clinic between October 2020 and March 2022. The patients were divided into two groups according to the severity of gastrointestinal involvement. The groups were compared in terms of demographic characteristics, gastrointestinal symptoms, laboratory parameters, other system involvement, length of hospital stay, treatment modalities, and clinical outcomes. Results: According to the severity of gastrointestinal system involvement, 44.7% (n=21) of the cases were mild to moderate, 55.3% (n=26) were severe. The most common gastrointestinal symptoms at presentation were abdominal pain (78.7%), vomiting (59.6%), and nausea (55.3%). Transaminase elevation was present in 29.8% of the cases. The most common radiological findings were ascites (36.2%) and pancreatic edema (27.7%). In cases presenting with acute pancreatitis (n=9), intensive care unit admission rates (n=6) were statistically significantly higher. Brain natriuretic peptide (p=0.020) and d-dimer (p=0.032) were statistically significantly higher in the severe group than in the mild to moderate group. Conclusions: In a significant part of the MIS-C cases with gastrointestinal involvement, severe findings is observed. Especially in cases presenting with pancreatitis, a more severe clinical course may be observed. Therefore, when managing patients presenting with gastrointestinal symptoms, the evaluation for pancreatitis is essential.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Pediatrik Multisistem İnflamatuvar Hastalıkta (MIS-C) Gastrointestinal Sistem Tutulumu: 47 Olgunun Tek Merkez Deneyimi

YÜCEL

Metin

2023

Journal of Contemporary Medicine

View full text Add to dashboard Cite

show abstract

“…Following the disease definition, fever, rash, cardiac, and GIS involvement signs were reported to be the most common clinical findings of MIS-C, in several cohort studies [14,15 & ,47, [55][56][57][58]. We tried to summarize the main characteristics of MIS-C patients in Table 1 There are also other miscellaneous cases whose cardinal signs have been uncommon such as acute pancreatitis, encephalopathy, cerebellitis, diabetic ketoacidosis, hepatitis, acute appendicitis, mesenteric lymphadenopathy, ocular myasthenia, and papilledema [70][71][72][73][74][75][76][77][78]. Despite the common similarities between Kawasaki disease and MIS-C, only one MIS-C case has been reported to have erythema and induration of Bacillus Calmette-Guerin (BCG) scar so far [79].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…There are also other miscellaneous cases whose cardinal signs have been uncommon such as acute pancreatitis, encephalopathy, cerebellitis, diabetic ketoacidosis, hepatitis, acute appendicitis, mesenteric lymphadenopathy, ocular myasthenia, and papilledema [70–78]. Despite the common similarities between Kawasaki disease and MIS-C, only one MIS-C case has been reported to have erythema and induration of Bacillus Calmette–Guerin (BCG) scar so far [79].…”

Section: Clinical Featuresmentioning

confidence: 99%

A cursed goodbye kiss from severe acute respiratory syndrome-coronavirus-2 to its pediatric hosts: multisystem inflammatory syndrome in children

Haşlak

Günalp

Kasapçopur

2022

Current Opinion in Rheumatology

View full text Add to dashboard Cite

Purpose of reviewWe aimed to summarize a novel disease called multisystem inflammatory syndrome in children (MIS-C), which develops several weeks after a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) illness. Recent findingsGiven the rarity of the disease, the question of why a minority of children develop MIS-C is not known. Certain intrinsic susceptibility factors in the host have been described. In addition to hyperinflammation induced by the innate and acquired immune cells, evidence of molecular mimicry was presented for the disease pathogenesis. As there is an increasing number of infected individuals and mass vaccination schedules, concerns regarding the usefulness of the existing diagnostic criteria sets raised.

show abstract

“…Pancreatic damage is, however, caused by changes in lipase levels. Acharyya, Bhaswati C DCH, MD(Ped), DNB(Paed), DNB(Gastro), MRCPCH(UK), FRCPCH(UK) * ; 4 A retrospective study analyzing data from 17 patients diagnosed with MISC-C and pancreatic impairment.…”

Section: Case Description Commentsmentioning

confidence: 99%

PIMS Mimicking Cystic Fibrosis in Infants

Luca¹,

Panait²,

Atanasiu³

et al. 2022

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Letters to the EditorThe published literature views the gastrointestinal tract as a target point for the SARS-CoV-2 virus, through the presence of numerous receptors that internalize the virus in the digestive cells (the angiotensin-converting enzyme receptors). 2 The present letter to the editor highlights the possible misleading aspects of the gastrointestinal disease that ultimately proved to be PIMS.

show abstract

Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children—A Single Center Experience

Abstract: Supplemental Digital Content is available in the text.

Cited by 8 publications

References 25 publications

Pediatrik Multisistem İnflamatuvar Hastalıkta (MIS-C) Gastrointestinal Sistem Tutulumu: 47 Olgunun Tek Merkez Deneyimi

Pediatrik Multisistem İnflamatuvar Hastalıkta (MIS-C) Gastrointestinal Sistem Tutulumu: 47 Olgunun Tek Merkez Deneyimi

A cursed goodbye kiss from severe acute respiratory syndrome-coronavirus-2 to its pediatric hosts: multisystem inflammatory syndrome in children

PIMS Mimicking Cystic Fibrosis in Infants

Contact Info

Product

Resources

About