Acute Pancreatitis in Mild COVID-19 Infection

Lakshmanan, Seetha; Malik, Amer

doi:10.7759/cureus.9886

Cited by 26 publications

(22 citation statements)

References 8 publications

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“…Gonzalo-Voltas et al 9 reported a case of pancreatitis from Spain in the absence of the most common risk factors: alcohol and gallstones. 9 Lakshmanan and Malik 10 also reported a case of a nursing home resident who tested positive for SARS-CoV-2 following an outbreak at his residence and developed pancreatitis a few days later. Moreover, Brikman et al 11 reported a case of a patient with COVID-19 pneumonia who developed acute pancreatitis 14 days following admission.…”

Section: Discussionmentioning

confidence: 99%

Acute pancreatitis in a patient with COVID-19

et al. 2021

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COVID-19 mainly causes pulmonary disease. Involvement of gastrointestinal and hepatobiliary systems, among other systems, has been reported. We report a case of acute pancreatitis in a patient with resolving COVID-19 pneumonia. History taking and investigations excluded other causes of pancreatitis. This case demonstrates the possibility of pancreatic injury in patients with COVID-19, in line with previously reported similar cases. We believe that it is imperative to screen patients presenting with acute pancreatitis for SARS-CoV-2. It is also important to take into consideration that patients with a complicated course who require an invasive procedure such as drainage might pose a risk of transmission to the operating surgeon or interventionist.

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Section: Discussionmentioning

confidence: 99%

Acute pancreatitis in a patient with COVID-19

et al. 2021

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“…[42][43][44][45] Since the beginning of the pandemic, associations have been drawn between COVID-19 infection and pancreatic injury and pancreatitis. Case reports have detailed the development of clinical pancreatitis following COVID-19 infection, [46][47][48][49][50] and several studies have suggested that elevations in amylase and lipase may be a fairly common feature of infection. 51,52 As noted above in studies focused on the islet, data on whether ACE2 is enhanced or decreased in pancreatic exocrine cells are conflicting, with some datasets suggesting an increase in ACE2 expression in the exocrine pancreas 40,53,54 and others suggesting relative depletion among the exocrine cells.…”

Section: Effects On β Cells Due To Infection Of Surrounding Cellsmentioning

confidence: 99%

Not so sweet and simple: impacts of SARS-CoV-2 on the β cell

Ibrahim

Monaco

Sims

2021

Islets

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The link between COVID-19 infection and diabetes has been explored in several studies since the start of the pandemic, with associations between comorbid diabetes and poorer prognosis in patients infected with the virus and reports of diabetic ketoacidosis occurring with COVID-19 infection. As such, significant interest has been generated surrounding mechanisms by which the virus may exert effects on the pancreatic β cells. In this review, we consider possible routes by which SARS-CoV-2 may impact β cells. Specifically, we outline data that either support or argue against the idea of direct infection and injury of β cells by SARS-CoV-2. We also discuss β cell damage due to a "bystander" effect in which infection with the virus leads to damage to surrounding tissues that are essential for β cell survival and function, such as the pancreatic microvasculature and exocrine tissue. Studies elucidating the provocation of a cytokine storm following COVID-19 infection and potential impacts of systemic inflammation and increases in insulin resistance on β cells are also reviewed. Finally, we summarize the existing clinical data surrounding diabetes incidence since the start of the COVID-19 pandemic.

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“…Lakshmanan et al [ 30 ] reported the case of a 68-year-old man with pneumonia and AP manifesting with nausea, vomiting, and anorexia, without abdominal pain, with increased amylase and lipase levels in laboratory results. Abdominal CT showed pancreatic and peripancreatic inflammation typical for AP.…”

Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

“…Conservative treatment (intravenous fluids, analgesics, antibiotics, and antiemetics) was used. After 7 d of treatment, he was discharged in good clinical condition[ 30 ].…”

Section: Case Reports and Cohort Studies On Ap In Covid-19 In The Literature Searchmentioning

confidence: 99%

Association between acute pancreatitis and COVID-19 infection: What do we know?

Jabłońska

Mrowiec

2021

WJGS

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The disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called coronavirus disease 2019 (COVID-19), first originated in Wuhan, China, displaying atypical pneumonia-like respiratory symptoms in affected patients. SARS-CoV-2 primarily attacks the respiratory system, and the most common symptoms include cough, shortness of breath, and fever. However, its impact on the digestive system has been shown, and various clinical gastrointestinal manifestations of this disease have been recognized. Some reports have shown acute pancreatitis (AP) as the initial symptom in patients with COVID-19. AP may be a consequence of direct pancreatic damage by the virus because pancreatic acinar cells contain angiotensin-converting enzyme 2 receptor proteins, and SARS-CoV-2 can bind to these receptors, causing pancreatic injury. Moreover, AP may be a secondary indicator of cytokine storms and altered inflammatory responses. Our review of the literature shows that SARS-CoV-2 appears to be a new etiological infectious factor related to AP. In this manuscript, a comprehensive review of case reports and case series of patients with AP and COVID-19 is presented. All reports on COVID-19-associated AP are summarized. All cases are thoroughly analyzed and discussed in-depth.

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Acute Pancreatitis in Mild COVID-19 Infection

Cited by 26 publications

References 8 publications

Acute pancreatitis in a patient with COVID-19

Acute pancreatitis in a patient with COVID-19

Not so sweet and simple: impacts of SARS-CoV-2 on the β cell

Association between acute pancreatitis and COVID-19 infection: What do we know?

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