Acute Perforated Appendicitis Secondary to Sarcoidosis

Policha, Aleksandra; Hu, Carol; Holmes, Phoebe; Cohn, John R.; Martin, Niels

doi:10.1177/000313481207800548

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“…[10][11][12] Colonic narrowing and mechanical obstruction have been reported, with multiple cases identifying sarcoidosis resulting in acute appendicitis and perforation. 13 Sarcoidosis of the appendix and rectum is reported less frequently, even among patients with colonic sarcoidosis. 6 The differential for colonic sarcoidosis is limited.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Sarcoidosis Masquerading as Colonic Polyps on Screening Colonoscopy

Ufondu¹,

Hillerson²,

Shwetar³

et al. 2022

ACG Case Rep J

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Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Sarcoidosis Masquerading as Colonic Polyps on Screening Colonoscopy

Ufondu¹,

Hillerson²,

Shwetar³

et al. 2022

ACG Case Rep J

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The manifestations of rare organ sarcoidosis

Judson¹,

Pastré²,

Israël‐Biet³

2022

Sarcoidosis

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Sarcoidosis Involving the Gastrointestinal Tract: Diagnostic and Therapeutic Management

et al. 2019

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Involvement of the gastrointestinal (GI) tract is an infrequent extrathoracic presentation of sarcoidosis. We reviewed 305 cases of GI involvement reported in 238 patients, in whom GI sarcoidosis was the first sign of the disease in half the cases. The disease does not affect the GI tract uniformly, with a clear oral-anal gradient (80% of reported cases involved the esophagus, stomach, and duodenum). Clinicopathological mechanisms of damage may include diffuse mucosal infiltration, endoluminal exophytic lesions, involvement of the myenteric plexus, and extrinsic compressions. Ten percent of patients presented with asymptomatic or subclinical disease found on endoscopy. The diagnosis is relevant clinically because 22% of cases reviewed presented as life threatening. In addition, initial clinical/endoscopic findings may be highly suggestive of GI cancer. The therapeutic approach is heterogeneous and included wait-and-see or symptomatic approaches, glucocorticoid/immunosuppressive therapy, and surgery. Sarcoidosis of the gut is a heterogeneous, potentially life-threatening condition that requires a multidisciplinary approach and early clinical suspicion to institute personalized therapeutic management and follow-up.

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Acute Perforated Appendicitis Secondary to Sarcoidosis

Cited by 3 publications

References 4 publications

A Rare Presentation of Sarcoidosis Masquerading as Colonic Polyps on Screening Colonoscopy

A Rare Presentation of Sarcoidosis Masquerading as Colonic Polyps on Screening Colonoscopy

The manifestations of rare organ sarcoidosis

Sarcoidosis Involving the Gastrointestinal Tract: Diagnostic and Therapeutic Management

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