Acute phase protein concentrations after limited distance and long distance endurance rides in horses

Cywińska, Anna; Szarska, Ewa; Gorecka, R.; Witkowski, Lucjan; Hecold, Mateusz; Bereznowski, A.; Schollenberger, A.; Winnicka, A.

doi:10.1016/j.rvsc.2012.02.008

Cited by 58 publications

(77 citation statements)

References 26 publications

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“…There was no significant difference between groups with regard to the median serum fibrinogen, haptoglobin and CRP concentrations. Moreover, results of all measured acute phase proteins remained within reference values established for horses (Pollock et al 2005, Cywińska et al 2012). …”

Section: Acute Phase Proteinssupporting

confidence: 73%

“…The APPs chose in this study were fibrinogen, haptoglobin and C -reactive protein (CRP), since they are commonly used in equine practice and their evaluation is relatively inexpensive (Cywińska et al 2012). CICs were selected since it is necessary to establish additional marker of inflammation that would be useful in early stage of diseases exacerbation.…”

Section: Discussionmentioning

confidence: 99%

“…Fibrinogen, haptoglobin and the C -reactive protein are acute phase proteins of moderate importance in horses (Cywińska et al 2012). During the acute inflammation phase their concentrations increase 5-10x and are maintained at such a level up to a few weeks after the remission of the disease.…”

Section: Discussionmentioning

confidence: 99%

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Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Niedźwiedź¹,

Jaworski²,

Kubiak³

2014

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the levels of circulating immune complexes (CICs) and concentration of haptoglobin, fibrinogen and C-reactive protein in the serum of horses with recurrent airway obstruction and healthy controls. The study was conducted on a group of 14 adult Polish Konik horses, kept in uniform environmental and living conditions. Horses were divided into two groups: 7 horses were not affected by any respiratory problem (control group) and 7 horses had a history of recurrent airway obstruction (RAO) (study group). A clinical and laboratory evaluation, endoscopic examination and bronchoalveolar lavage (BAL) were performed in all horses. Levels of circulating immune complexes were significantly (p=0.0057) increased in heaves-affected horses compared to healthy controls (median [25 th -75 th percentiles]) (3.96 [3.96 -4.43] vs. 7.46 [5.13 -11.9]). No significant difference was observed in the levels of the examined acute phase proteins between the groups. Moreover, all results were within the reference range established for horses. The results of this study indicate that heaves in horses is associated with the formation and high level of CICs. Haptoglobin, fibrinogen and C-reactive protein failed as markers of early stage systemic inflammation in the course of RAO.

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Section: Acute Phase Proteinssupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Niedźwiedź¹,

Jaworski²,

Kubiak³

2014

Polish Journal of Veterinary Sciences

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“…[28][29][30] Submaximal training efforts usually do not alter muscle enzyme values in healthy individuals; however, endurance competition commonly results in a several thousand units per liter increase in serum CK activity in apparently healthy horses. 15,16,[21][22][23]31,32 Exertional rhabdomyolysis disorders of the performance horse, including recurrent exertional rhabdomyolysis (RER) and polysaccharide storage myopathy (PSSM), are described in detail in other chapters of this text. However, it should be recognized that serum enzyme elevations can be extremely variable in horses affected with these disorders, and increases can range from between several thousand to hundreds of thousands of units per liter in affected individuals.…”

Section: Muscle Enzyme Activitiesmentioning

confidence: 99%

Biochemical abnormalities of athletic horses

McKenzie¹

2014

Equine Sports Medicine and Surgery

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“…Interactions between acute phase, oxidative status and muscle injury were evaluated thoroughly in horses during exercise (Chiaradia et al 1998, Linder and Hatzipanagiotou 1998, Hargreaves et al 2002, Marlin et al 2002, Cywińska et al 2012. Furthermore, there are some reports documenting acute phase response during transport (Casella et al 2012) as well as oxidative status (Ishida et al 1999, Onmaz et al 2011) and muscle injury (Stull and Rodiek 2000).…”

mentioning

confidence: 99%

Transport induced inflammatory responses in horses

Wessely-Szponder¹,

Bełkot²,

Bobowiec³

et al. 2015

Polish Journal of Veterinary Sciences

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Deleterious response to road transport is an important problem in equine practice. It determines different physiological, immunological and metabolic changes which lead to increased susceptibility to several disorders such as pneumonia, diarrhea, colics, laminitis, injuries and rhabdomyolisis. The aim of our study was to look for possible relationships between transportation of female young and older horses over a long and short distance and an inflammatory state reflected by an increase of acute phase protein concentration, oxidative stress and muscle injury. The study was conducted on 24 cold-blooded female horses divided into four groups. Six fillies aged 6-18 months and six mares aged 10-12 years were transported over the distance of about 550 km, six fillies aged 6-18 months and six mares aged 10-12 years were transported over the distance of about 50 km. Plasma and serum were obtained from blood samples taken before transportation (T0), immediately after transportation (T1) and at an abattoir during slaughter (T2). In these samples fibrinogen, MDA, AST and CK were assessed. Fibrinogen increased in all studied groups especially in fillies after long distance transportation, where it reached 205±7.07 mg/dl before transportation, 625±35.35 mg/dl after transportation, and 790±14.14 mg/dl during slaughter. MDA concentrations rose after transportation and reached the maximal level during slaughter. CK activity was more elevated after short transportation in younger horses, whereas initial activity of AST was higher in older horses. We estimated that intensified responses from acute phase, oxidative stress and muscle injury parameters indicated an inflammatory state.

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Acute phase protein concentrations after limited distance and long distance endurance rides in horses

Cited by 58 publications

References 26 publications

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Circulating immune complexes and markers of systemic inflammation in RAO-affected horses

Biochemical abnormalities of athletic horses

Transport induced inflammatory responses in horses

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