Acute phase proteins in naturally occurring respiratory disease of feedlot cattle

Idoate, Ignacio; Ley, B. L. Vander; Schultz, Loren G.; Heller, Meera C.

doi:10.1016/j.vetimm.2014.12.006

Cited by 34 publications

(32 citation statements)

References 27 publications

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“…In contrast, transferrin was not significantly lower in BRD cases compared with time-matched controls. 24 Furthermore, 94% of clinically sick cattle had HAP levels above the laboratory internal cutoff of 0.15 mg/mL and 76% had serum amyloid A levels above the cutoff (80.31 mg/mL). 29 It is noteworthy that cutoffs for HAP differ significantly between studies, which can be explained by the kits used (ie, Bovine Haptoglobin ELISA kit [Immunology Consultants Laboratories, Portland, OR 24 ] vs Bovine HAP ELISA kit [Tridelta Development Ltd, Maynooth, Ireland 29 ]).…”

Section: Acute Phase Proteinsmentioning

confidence: 96%

“…45 Changes in acute phase proteins have been associated with BRD in infection trials, 40,43 and naturally occurring BRD 24,29 ( Table 1). On days 0.5, 1, 2, 3, and 7 after M haemolytica infection, HAP was increased in infected versus control cattle with no difference reported on day 9 after infection.…”

Section: Acute Phase Proteinsmentioning

confidence: 99%

“…40 Comparable results were reported in naturally occurring BRD outbreaks. 24,29 In a receiver-operator characteristics analysis comparing clinical illness to acute phase protein levels, both serum HAP (cutoff !0.81 mg/mL) and LBP (!0.33 mg/mL) levels were 93% sensitive. Specificity was 86% for HAP and 93% for LBP.…”

Section: Acute Phase Proteinsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle

Wolfger

Timsit

White

et al. 2015

Veterinary Clinics of North America: Food Animal Practice

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Section: Acute Phase Proteinsmentioning

confidence: 96%

Section: Acute Phase Proteinsmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle

Wolfger

Timsit

White

et al. 2015

Veterinary Clinics of North America: Food Animal Practice

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“…The flow diagram outlining the selection strategy to obtain 25 articles is summarized in Figure . Twenty‐three studies, , , were ultimately included. Two articles described studies already reported in different journals…”

Section: Resultsmentioning

confidence: 99%

Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease

Abdallah

Hewson

Francoz

et al. 2016

Veterinary Internal Medicne

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BackgroundBovine respiratory disease (BRD) is a worldwide animal health concern especially in feedlot, dairy, and veal calves. One of the greatest challenges is the absence of a gold standard for achieving an accurate antemortem diagnosis. Various blood markers, including the acute‐phase proteins (AAP), have been proposed as potential valuable tools for BRD diagnosis.ObjectivesTo perform a systematic review of the literature to assess the accuracy of selected APP (haptoglobin [Hp], serum amyloid A [SAA], and fibrinogen [Fb]) as diagnostic tools for cattle with naturally occurring BRD when compared with clinical reference standards of diagnosis.MethodsThis review was performed with eligible studies selected from CAB Abstract and MEDLINE from 1946 to 2015, as well as the “gray literature.” Methodological quality of included studies was assessed using the QUADAS‐2 tool developed for diagnostic accuracy studies. The accuracy parameters sensitivity (Se) and specificity (Sp) were obtained from the articles or through contact with the authors when not directly reported.ResultsA total of 314 studies were identified, from them, 23 met inclusion criteria as diagnostic studies for naturally occurring BRD. Quality of studies showed high risk of bias for case selection (70% of articles) and unclear risk of bias for index test (65%), reference standard (74%), and flow and timing (61%). There were high concerns regarding applicability for case selection (61% of studies) and reference standards used for defining BRD (48%). The concerns regarding index test application were low (83% of the studies). Only 4–8 studies could be included in the meta‐analysis for each APP. No pooled estimates or pooled accuracy measurements were performed due to the low number of studies and multiple differences between studies, including reference standard definitions.Conclusions and Clinical ImportanceOn the basis of these findings, it is not possible to make conclusions regarding the accuracy of APP for BRD diagnosis. The reporting of accuracy of APP for BRD detection is inconsistent among studies. Recommendations to improve capability for future meta‐analyses in this area include reporting studies on diagnostic tests following the Standard for the Reporting of Diagnostic Accuracy Studies (STARD), as well as trying to standardize BRD definition across future studies.

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“…LBP binds to the amphipathic lipid A moiety of LPS with high affinity and presents the LPS to pattern-recognition receptors CD14, initiating signal transduction pathways leading to the activation of the inflammatory host response (Idoate et al 2015). A polypeptide with a threonine (T)-to-methionine (M) mutation in amino acid 287 of LBP had high anti-endotoxin activity in vitro and in vivo, which suggested that amino acid 287 in the C-terminus of LBP may play an important role in LBP binding with CD14 (Fang et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effect of recombinant bovine wild and mutant lipopolysaccharide-binding protein in lipopolysaccharide-challenged bovine mammary epithelial cells

Sun

et al. 2016

Cell Stress and Chaperones

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Lipopolysaccharide (LPS)-binding protein (LBP) plays a crucial role in the recognition of bacterial components, such as LPS that causes an immune response. The aim of this study was to compare the different effects of recombinant bovine wild LBP and mutant LBP (67 Ala → Thr) on the LPSinduced inflammatory response of bovine mammary epithelial cells (BMECs). When BMECs were treated with various concentrations of recombinant bovine lipopolysaccharide-binding protein (RBLBP) (1, 5, 10, and 15 μg/mL) for 12 h, RBLBP of 5 μg/mL increased the apoptosis of BMECs induced by LPS without cytotoxicity, and mutant LBP resulted in a higher cell apoptosis than wild LBP did. By gene-chip microarray and bioinformatics, the data identified 2306 differentially expressed genes that were changed significantly between the LPSinduced inflamed BMECs treated with 5 μg/mL of mutant LBP and the BMECs only treated with 10 μg/mL of LPS (fold change ≥2). Meanwhile, 1585 genes were differently expressed between the inflamed BMECs treated with 5 μg/mL of wild LBP and 10 μg/mL of LPS-treated BMECs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that these differentially expressed genes were involved in different pathways that regulate the inflammation response. It predicted that carriers of this mutation increase the risk for a more severe inflammatory response. Our study provides an overview of the gene expression profile between wild LBP and mutant LBP on the LPS-induced inflammatory response of BMECs, which will lead to further understanding of the potential effects of LBP mutations on bovine mammary glands.

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Acute phase proteins in naturally occurring respiratory disease of feedlot cattle

Cited by 34 publications

References 27 publications

A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle

A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle

Systematic Review of the Diagnostic Accuracy of Haptoglobin, Serum Amyloid A, and Fibrinogen versus Clinical Reference Standards for the Diagnosis of Bovine Respiratory Disease

Comparison of the effect of recombinant bovine wild and mutant lipopolysaccharide-binding protein in lipopolysaccharide-challenged bovine mammary epithelial cells

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