Acute plasticity in the human somatosensory cortex following amputation

Borsook, David; Becerra, Lino; Fishman, Scott M.; Edwards, Annabel; Jennings, Candace; Stojanovic, M.; Papinicolas, L; Ramachandran, V. S.; González, R. Gilberto; Breiter, Hans C.

doi:10.1097/00001756-199804200-00011

Cited by 208 publications

(113 citation statements)

References 14 publications

Supporting

Mentioning

107

Contrasting

Unclassified

Order By: Relevance

“…Cutaneous anaesthesia of the forearm enhances tactile discrimination and the perception of touch in the hand (Bjorkman et al, 2004), presumably because anaesthesia unmasks latent excitatory influences in the thalamus or higher cortical centres. A similar process may account for the rapid development of referred and phantom limb sensations, including pain, following limb amputation (Ramachandran and Hirstein, 1998;Borsook et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Sensory changes in the forehead of patients with complex regional pain syndrome

Drummond

Finch²

2006

Pain

View full text Add to dashboard Cite

The aim of this study was to investigate involvement of central mechanisms in complex regional pain syndrome (CRPS). In particular, we wished to determine whether hyperalgesia extends ipsilaterally from the affected limb to the forehead. The heat-pain threshold, pressure-pain threshold, and ratings of cold and sharpness were investigated on each side of the forehead and in the affected and unaffected limbs of 38 patients with features of CRPS. In addition, touch thresholds were investigated in the limbs. The pressure-pain threshold was lower on the ipsilateral forehead than contralaterally, consistent with the presence of static mechanical hyperalgesia.Although the heat-pain threshold and ratings of sharpness and cold did not differ between the two sides of the forehead in the group as a whole, the sharpness of pinprick sensations in the affected limb was mirrored by similar sensations in the ipsilateral forehead. Conversely, diminished sensitivity to light touch in the affected limb was associated with diminished sensitivity to sharpness, cold and heat-pain in the ipsilateral forehead. These findings suggest that central nociceptive processing is disrupted in CRPS, possibly due to disturbances in the thalamus or higher cortical centres.

show abstract

Section: Discussionmentioning

confidence: 99%

Sensory changes in the forehead of patients with complex regional pain syndrome

Drummond

Finch²

2006

Pain

View full text Add to dashboard Cite

show abstract

“…Subsequent PET studies looked at processing during brush-induced allodynia after nerve injury (Witting et al, 2006) and heat allodynia in a patient with neuropathic pain (Casey et al, 2003). Functional magnetic resonance imaging (fMRI) reports include investigations of complex regional pain syndrome (Maihofner and Handwerker, 2005), central pain from syringomyelia (Ducreux et al, 2006), mechanical allodynia in patients with neuropathic pain of central and peripheral origin (Peyron et al, 2004;Hofbauer et al, 2006), and phantom pain (Borsook et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli

Becerra

Morris²,

Bazes³

et al. 2006

J. Neurosci.

175

140

View full text Add to dashboard Cite

Functional magnetic resonance imaging was used to study patients with chronic neuropathic pain involving the maxillary region (V2) of the trigeminal nerve in patients with spontaneous pain and evoked pain to brush (allodynia). Patients underwent two functional scans (2-3 months apart) with mechanical and thermal stimuli applied to the affected region of V2 and to the mirror site in the unaffected contralateral V2 region, as well as bilaterally to the mandibular (V3) division. Patients were stimulated with brush, noxious cold, and noxious heat. Significant changes were observed in regions within and outside the primary trigeminal sensory pathway. Stimulation to the affected (neuropathic) side resulted in predominantly frontal region and basal ganglia activation compared with the control side. The differences were consistent with the allodynia to brush and cold. A region of interest-based analysis of the trigeminal sensory pathway revealed patterns of activation that differentiated between the affected and unaffected sides and that were particular to each stimulus. Activation in the spinal trigeminal nucleus was constant in location for all pain stimuli. Activation in other brainstem nuclei also showed differences in the blood oxygenation level-dependent signal for the affected versus the unaffected side. Thus, sensory processing in patients with trigeminal neuropathic pain is associated with distinct activation patterns consistent with sensitization within and outside of the primary sensory pathway.

show abstract

“…Accurate and detailed somatotopic mapping of the human body surface will improve basic understanding of the somatosensory system, guide neurosurgical planning, and assess plasticity and recovery after brain damage or body injuries (Borsook et al, 1998;Corbetta et al, 2002;Cramer et al, , 2003Cramer and Bastings, 2000;Cramer and Crafton, 2006;Lee et al, 1998Lee et al, , 1999Moore et al, 2000b;Ramachandran, 2005;Ramachandran and Rogers-Ramachandran, 2000;Rijntjes et al, 1997). Studies using fMRI have revealed somatotopic representations of the hand, fingers, wrist, elbow, shoulder, foot, toes, lips, and tongue in human brains (Alkadhi et al, 2002;Beisteiner et al, 2001;Blankenburg et al, 2003;Dechent and Frahm, 2003;Francis et al, 2000;Gelnar et al, 1998;Golaszewski et al, 2006;Hanakawa et al, 2005;Hlustik et al, 2001;Kurth et al, 2000;Lotze et al, 2000;McGlone et al, 2002;Miyamoto et al, 2006;Moore et al, 2000a;Overduin and Servos, 2004;Ruben et al, 2001;Servos et al, 1998;Stippich et al, 1999Stippich et al, , 2004van Westen et al, 2004; also see reviews in Burton, 2002).…”

Section: Introductionmentioning

confidence: 99%

Dodecapus: An MR-compatible system for somatosensory stimulation

Huang

Sereno

2007

NeuroImage

View full text Add to dashboard Cite

Somatotopic mapping of human body surface using fMRI is challenging. First, it is difficult to deliver tactile stimuli in the scanner. Second, multiple stimulators are often required to cover enough area of the complex-shaped body surface, such as the face. In this study, a computer-controlled pneumatic system was constructed to automatically deliver air puffs to 12 locations on the body surface through an MR-compatible manifold (Dodecapus) mounted on a head coil inside the scanner bore. The timing of each air-puff channel is completely programmable and this allows systematic and precise stimulation on multiple locations on the body surface during functional scans. Three two-condition block-design "Localizer" paradigms were employed to localize the cortical representations of the face, lips, and fingers, respectively. Three "Phase-encoded" paradigms were employed to map the detailed somatotopic organizations of the face, lips, and fingers following each "Localizer" paradigm. Multiple somatotopic representations of the face, lips, and fingers were localized and mapped in primary motor cortex (MI), ventral premotor cortex (PMv), polysensory zone (PZ), primary (SI) and secondary (SII) somatosensory cortex, parietal ventral area (PV) and 7b, as well as anterior and ventral intraparietal areas (AIP and VIP). The Dodecapus system is portable, easy to setup, generates no radio frequency interference, and can also be used for EEG and MEG experiments. This system could be useful for non-invasive somatotopic mapping in both basic and clinical studies.

show abstract

Acute plasticity in the human somatosensory cortex following amputation

Cited by 208 publications

References 14 publications

Sensory changes in the forehead of patients with complex regional pain syndrome

Sensory changes in the forehead of patients with complex regional pain syndrome

Trigeminal Neuropathic Pain Alters Responses in CNS Circuits to Mechanical (Brush) and Thermal (Cold and Heat) Stimuli

Dodecapus: An MR-compatible system for somatosensory stimulation

Contact Info

Product

Resources

About