Acute prefrontal rTMS increases striatal dopamine to a similar degree as d-amphetamine

Pogarell, Oliver; Koch, Walter; Pöpperl, Gabriele; Tatsch, Klaus; Jakob, Franziska; Mulert, Christoph; Großheinrich, Nicola; Rupprecht, Rainer; Möller, Hans‐Jürgen; Hegerl, Ulrich; Padberg, Frank

doi:10.1016/j.pscychresns.2007.05.002

Cited by 107 publications

(48 citation statements)

References 13 publications

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“…First, the left DLPFC has long been implicated in depression [50–53] and has been the most effective stimulation site studied [54,55]. Second, intact functional connectivity between cortex proximal to the stimulation site and the striatum may enable enhancements in dopamine signaling which have been shown to be activated by TMS over ipsilateral DLPFC [35–37] and can lead to antidepressant effects [56,57]. …”

Section: Discussionmentioning

confidence: 99%

“…Third, TMS over frontal cortex induces striatal dopamine release in animal models [33,34] and in normal humans [35]. Finally, TMS over the left DLPFC induces striatal dopamine release in depressed subjects [36,37], suggesting that the integrity of this frontostriatal connection may be important for successful treatment if dopamine release is a mediator of the antidepressant effect of TMS.…”

Section: Introductionmentioning

confidence: 99%

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Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS

et al. 2017

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Background Repetitive transcranial magnetic stimulation (TMS) is a non-invasive, safe, and efficacious treatment for depression. TMS has been shown to normalize abnormal functional connectivity of cortico-cortical circuits in depression and baseline functional connectivity of these circuits predicts treatment response. Less is known about the relationship between functional connectivity of frontostriatal circuits and treatment response. Objective/Hypothesis We investigated whether baseline functional connectivity of distinct frontostriatal circuits predicted response to TMS. Methods Resting-state fMRI (rsfMRI) was acquired in 27 currently depressed subjects with treatment resistant depression and 27 healthy controls. Depressed subjects were treated with 5 weeks of daily TMS over the left dorsolateral prefrontal cortex (DLPFC). The functional connectivity between limbic, executive, rostral motor, and caudal motor regions of frontal cortex and their corresponding striatal targets were determined at baseline using an existing atlas based on diffusion tensor imaging. TMS treatment response was measured by percent reduction in the 24-item Hamilton Depression Rating Scale (HAMD24). In an exploratory analysis, correlations were determined between baseline functional connectivity and TMS treatment response. Results Seven cortical clusters belonging to the executive and rostral motor frontostriatal projections had reduced functional connectivity in depression compared to healthy controls. No frontostriatal projections showed increased functional connectivity in depression (voxel-wise p < 0.01, familywise α < 0.01). Only baseline functional connectivity between the left DLPFC and the striatum predicted TMS response. Higher baseline functional connectivity correlated with greater reductions in HAMD24 (Pearson’s R = 0.58, p = 0.002). Conclusion(s) In an exploratory analysis, higher functional connectivity between the DLPFC and striatum predicted better treatment response. Our findings suggest that the antidepressant mechanism of action of TMS may require connectivity from cortex proximal to the stimulation site to the striatum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS

et al. 2017

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“…However, the involvement of the left side DLPFC, which appears to be closely related to depressed mood in IGD in the current study, could be considered as a potential biomarker for IGD with comorbid depression based on clinical evidence from the repetitive transcranial magnetic stimulation (rTMS) over the DLPFC. The DLPFC stimulation modulates dopamine release in brain areas of the limbic system 64, 65 . Accumulating evidence suggests that the left DLPFC is more responsive to positive emotional information in healthy people, so that the stimulation over it in depressed people is known to enhance the response to positive stimuli by inducing cortical excitability in the left side 66–68 , whereas the right DLPFC is more responsive to negative emotional information and more involved in the cognitive modulation of emotional stimuli 66, 69 .…”

Section: Discussionmentioning

confidence: 99%

Structural alterations in the prefrontal cortex mediate the relationship between Internet gaming disorder and depressed mood

Choi

Cho

Kim

et al. 2017

Sci Rep

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Adaptive gaming use has positive effects, whereas depression has been reported to be prevalent in Internet gaming disorder (IGD). However, the neural correlates underlying the association between depression and Internet gaming remain unclear. Moreover, the neuroanatomical profile of the striatum in IGD is relatively less clear despite its important role in addiction. We found lower gray matter (GM) density in the left dorsolateral prefrontal cortex (DLPFC) in the IGD group than in the Internet gaming control (IGC) group and non-gaming control (NGC) group, and the GM density was associated with lifetime usage of Internet gaming, depressed mood, craving, and impulsivity in the gaming users. Striatal volumetric analysis detected a significant reduction in the right nucleus accumbens (NAcc) in the IGD group and its association with lifetime usage of gaming and depression. These findings suggest that alterations in the brain structures involved in the reward system are associated with IGD-related behavioral characteristics. Furthermore, the DLPFC, involved in cognitive control, was observed to serve as a mediator in the association between prolonged gaming and depressed mood. This finding may provide insight into an intervention strategy for treating IGD with comorbid depression.

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“…Indeed, the DLPFC receives direct input from the dopamine mesocortical pathway, originating from the VTA, and projects to the basal ganglia, hippocampus and thalamus (Goldman-Rakic, 1996). It has been reported that rTMS to the DLPFC can enhance dopamine transmission in the striatum (Pogarell et al, 2007), ACC and OFC (Ko and Strafella, 2011); and tES can modulate GABA and glutamate transmission, as shown by the stimulation of the primary motor cortex (Nitsche and Liebetanz, 2004; Stagg et al, 2009). Thus, several authors have proposed that the reduction in craving following stimulation may be mediated by the frontolimbic connections of the DLPFC with structures of the basal ganglia.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Hone‐Blanchet

Ciraulo

Pascual‐Leone

et al. 2015

Neuroscience & Biobehavioral Reviews

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Substance use disorders (SUDs) can be viewed as a pathology of neuroadaptation. The pharmacological overstimulation of neural mechanisms of reward, motivated learning and memory leads to drug-seeking behavior. A critical characteristic of SUDs is the appearance of craving, the motivated desire and urge to use, which is a main focus of current pharmacological and behavioral therapies. Recent proof-of-concept studies have tested the effects of non-invasive brain stimulation on craving. Although its mechanisms of action are not fully understood, this approach shows interesting potential in tuning down craving and possibly consumption of diverse substances. This article reviews available results on the use of repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES) in SUDs, specifically tobacco, alcohol and psychostimulant use disorders. We discuss several important factors that need to be addressed in future works to improve clinical assessment and effects of non-invasive brain stimulation in SUDs. Factors discussed include brain stimulation devices and parameters, study designs, brain states and subjects’ characteristics.

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Acute prefrontal rTMS increases striatal dopamine to a similar degree as d-amphetamine

Cited by 107 publications

References 13 publications

Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS

Functional connectivity of the left DLPFC to striatum predicts treatment response of depression to TMS

Structural alterations in the prefrontal cortex mediate the relationship between Internet gaming disorder and depressed mood

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

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