Acute promyelocytic leukaemia after treatment for seminoma with carboplatin

Snowden, John A.; Laidlaw, S.T.; Champion, A.E.; Reilly, John T.

doi:10.1016/s0140-6736(94)90717-x

Cited by 8 publications

(5 citation statements)

References 4 publications

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“…Radiotherapy was not used in either of our cases nor reported for the other three cases following single agent platinum treatment in the literature (Bassett & Weiss, 1986;Kaldor et al, 1990). However, the case reported by Snowden et al is the third case of sAML FAB type M3 to be reported following treatment with platinum compounds (Pogliani et al, 1993;Bassett & Weiss, 1986;Snowden et al, 1994). Of interest, the cases we report here both had a time course of leukaemogenesis more in keeping with the mechanism of direct DNA damage, but the first case had effectively monosomy 7q (the thrombocythaemia probably represents early dysplastic change) whereas the second had an 11q23 breakpoint, more usually associated with a shorter time between exposure and the development of leukaemia.…”

Section: Discussionmentioning

confidence: 73%

“…They commented upon the increased leukaemogenicity of the combination of cisplatin with doxorubicin. Snowden et al (1994) have recently reported a further case of acute promyelocytic leukaemia in a patient previously treated for seminoma with carboplatin (total dose 2 . 9 g) and radiotherapy (total dose 35 Gy of megavoltage radiotherapy given daily for 4 weeks to the para-aortic and pelvic region).…”

Section: Discussionmentioning

confidence: 99%

“…The time course of leukaemogenesis in other published cases varies from immediately following the 29th cisplatin dose (2 . 5 years from first dose) (Bassett & Weiss, 1986) to 6 years following treatment (Snowden et al, 1994). t(9;11) occurs at a frequency of about 2% of all clonal abnormalities in AML, and is generally associated with M5a or secondary AML ( Johansson et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

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Platinum Agents and Secondary Myeloid Leukaemia: Two Cases Treated Only With Platinum‐based Drugs

et al. 1996

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With the increasing use of chemotherapy for many different primary malignancies, secondary or therapy-related acute myeloid leukaemias (AML) and myelodysplastic syndromes (MDS) are becoming more common. The risk of developing sAML has been estimated to be between 2% and 10%, depending upon the type, duration and dosage of previous therapy (Michels et al, 1985; Shulman, 1993; Robinson & Mertens, 1993; Ballen & Antin, 1993). It is therefore one of the most serious long-term complications of current cancer treatment and is likely to increase as longer survival rates for the primary tumour are achieved. An increasing range of drugs have been reported to cause sAML, including the alkylating agents, the epipodophyllotoxins and the anthracyclines, both as single agents and in combination (Pedersen-Bjergaard & Philip, 1991; Pedersen-Bjergaard & Rowley, 1994). We report two cases of secondary AML in which platinum compounds were the sole prior chemotherapy.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Platinum Agents and Secondary Myeloid Leukaemia: Two Cases Treated Only With Platinum‐based Drugs

et al. 1996

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“…Information on long-term toxicity is scarce. However, a possible induction of secondary malignancies has been reported by some authors (Snowden et al 1994;Travis et al 1999 3.1% on average varying between 0±8.6% ( Table 2). These ®gures compare well to control rates reported for radiotherapy.…”

Section: Chemotherapymentioning

confidence: 88%

Treatment of early stage testicular seminoma

Claßen

Souchon²,

Hehr

et al. 2001

Journal of Cancer Research and Clinical Oncology

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Stage I and IIA/B testicular seminoma represent approximately 45% of all testicular germ cell tumours. Due to the availability of highly efficient salvage treatment, the disease-specific survival in stage I seminoma is approximately 100%, irrespective of the choice of adjuvant treatment. Radiotherapy with 26 Gy to the paraaortic/paracaval lymph nodes yields excellent cure rates of 95 98% with a favourable profile of acute and late toxicity. Likewise, phase-II trials with single-agent carboplatinum systemic treatment have demonstrated a rate of relapse of 3-4% on average. However, carboplatinum chemotherapy has to be regarded as experimental until data of phase-III trials are available. Surveillance in stage I disease is conflicted with a rate of relapse of approximately 20%. However, 80% of the patients will avoid potentially toxic overtreatment by the watch-and-wait policy. In stage IIA/B seminoma, "dogleg" radiotherapy with 30 Gy and 36 Gy, respectively, provides high cure rates of 90-95%. Those patients relapsing will be salvaged in almost 100% of cases. Testicular intraepithelial neoplasia (TIN) is the common precursor lesion of testicular germ cell tumours except for spermatocytic seminoma. In case of TIN in a single testis or bilateral TIN, local radiotherapy with 18 Gy is recommended as standard treatment.

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“…In ovarian cancer, platinum-based chemotherapy evidently increased the relative risk of developing acute leukemias in a dose-dependent manner whereas the radiation without chemotherapy did not increase the risk [5]. However, the evidence is not sufficient to conclude on the relationship between the therapyrelated APL (t-APL) after CCRTh and a chromosomal abnormality, since there are only few reported cases of t-APL after CCRTh per se [6,7]. In our case, since the interval between the chemotherapy of the cervical cancer to APL was much shorter than the median latency (24 months), it is possible that our case is indeed a therapy-related case, even though there is still the possibility that the two diseases coincidentally developed simultaneously.…”

Section: Case Reportmentioning

confidence: 99%