Acute Renal Failure Caused by Alcohol-Induced Rhabdomyolysis

Haapanen, E; Pellinen, Timo J.; Partanen, Juhaní

doi:10.1159/000183151

Cited by 16 publications

(10 citation statements)

References 7 publications

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“…The mortality rate from rhabdomyolysis is 8–10% and it increases if ARF develops 4 . Cases of severe ARF with the need of dialysis following alcohol-induced rhabdomyolysis have been reported 16 , 18 . The early recognition and treatment of rhabdomyolysis has a great significance for the prevention of ARF (incidence of renal injury: 4.7–94%) 19 .…”

Section: Discussionmentioning

confidence: 99%

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Papadatos

Deligiannis

Bazoukis

et al. 2015

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Papadatos

Deligiannis

Bazoukis

et al. 2015

Clinical Case Reports

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“…It is of interest that seven patients with alcohol intoxication were neither comatose nor had convulsions at any phase of the disease. It has been shown that in high concentrations ethanol is toxic to the muscles (9,16,18,19). Daily consumption of 225 g ethanol increases serum creatinine kinase activity and results in striking ultrastructural changes in skeletal muscles (19).…”

Section: Discussionmentioning

confidence: 99%

Acute Renal Failure Following Nontraumatic Rhabdomyolysis

Haapanen

Partanen

Pellinen

1988

Scandinavian Journal of Urology and Nephrology

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The etiology and clinical course of acute nontraumatic rhabdomyolysis and ensuing renal failure was surveyed in a series of 40 consecutive patients. In 28 cases the muscle damage occurred after excessive consumption of ethyl alcohol and/or other intoxications. Prolonged lying immobilized was the reason or contributing factor for rhabdomyolysis in 22 cases. The other evident etiologies were convulsions, vigorous physical exercise, arterial occlusion and hypothermia. Typical local signs of rhabdomyolysis--pain, swelling and weakness of the affected muscles--were absent in one fourth of the patients. In these cases the diagnosis was based on transient elevation of serum creatine kinase enzyme activity. Dialyses were required to manage acute renal failure in 24 subjects. All 36 survivors recovered normal renal function. Neurological defects in the extremities still persisted in 16 patients at three months' follow-up.

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“…Acute renal failure associated with alcohol misuse Acute renal failure (ARF) associated with alcohol abuse is usually attributed to rhabdomyolysis, 41,42 ethylene glycol or methanol poisoning, 43 and volume depletion or haemorrhage. 44 In addition, recent observations provide evidence of a syndrome of acute tubular necrosis due to binge drinking of ethanol in the absence of other evident nephrotoxic mechanisms, 4 or in association with the use of nonsteroidal anti-inflammatory drugs.…”

Section: Renal Abnormalities In Fetal Alcohol Syndromementioning

confidence: 99%

“…5,6 Acute renal failure and rhabdomyolysis The mechanism responsible for rhabdomyolysis in alcoholism is likely multifactorial, involving severe hypophosphataemia, hypokalaemia and probably direct toxic damage to the skeletal muscles by alcohol. 41,42 In most cases, rhabdomyolysis is clinically mild or asymptomatic, and is reflected only by elevated circulating levels of muscle enzymes. More dramatic, but less common, is severe rhabdomyolysis characterized by muscle cramps, tenderness, weakness, myoglobinuria and acute renal failure.…”

Section: Renal Abnormalities In Fetal Alcohol Syndromementioning

confidence: 99%

Alcohol misuse and renal damage

Cecchin¹,

Marchi²

1996

Addiction Biology

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Recent clinical and experimental studies have demonstrated that the habitual consumption of large amounts of ethanol has deleterious effects on the kidney. A variety of tubular defects have been described in patients with chronic alcoholism. Evidence is emerging that tubular dysfunction has an important pathophysiological role in a wide range of electrolyte and acid-base disturbances commonly observed in these patients, and possibly in alcohol-induced bone disease. These renal abnormalities are often reversible, disappearing with abstinence. However, since 1990 a few cases of a syndrome of acute tubular necrosis due to binge drinking of ethanol in the absence of other evident nephrotoxic mechanisms, or in association with the use of nonsteroidal anti-inflammatory drugs, have been reported. A link between glomerulonephritis and alcoholism has become evident. IgA nephropathy has been demonstrated at autopsy in 64% of chronic alcoholics and, more recently, the association between alcoholism and postinfectious glomerulonephritis has been described. Structural and functional abnormalities of the kidney are reported with increasing frequency in the fetal alcohol syndrome seen in children who have been prenatally exposed to ethanol. In addition, over the last few years experimental studies in vitro or in animal models have provided information about the biochemical and molecular basis of alcohol-induced injury to kidney. It is hoped that future experimental and clinical research will provide us with a more comprehensive knowledge of the mechanisms of renal damage in alcohol misuse.

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Acute Renal Failure Caused by Alcohol-Induced Rhabdomyolysis

Abstract: 5 cases of severe acute renal failure caused by ethyl alcohol-induced rhabdomyolysis are reviewed. 4 patients were dialyzed. All patients recovered completely from the renal failure.

Cited by 16 publications

References 7 publications

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Acute Renal Failure Following Nontraumatic Rhabdomyolysis

Alcohol misuse and renal damage

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