Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Papadatos, Stamatis S; Deligiannis, Georgios; Bazoukis, George; Michelongona, Paschalia; Spiliopoulou, Aikaterini; Mylonas, Stefanos; Zissis, Christos

doi:10.1002/ccr3.326

Cited by 25 publications

(28 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Alcohol may itself cause nontraumatic rhabdomyolysis, though this is a rare occurrence. The mechanism postulated is a disruption of the adenosine triphosphate (ATP) pump and skeletal membranes, induction of cytochrome p450 and alteration of sarcoplasmic reticulum [10]. Other mechanisms include prolonged coma, seizures, falls or immobility, and electrolyte disturbances; our patient had none of these [10].…”

Section: Discussionmentioning

confidence: 93%

“…The mechanism postulated is a disruption of the adenosine triphosphate (ATP) pump and skeletal membranes, induction of cytochrome p450 and alteration of sarcoplasmic reticulum [10]. Other mechanisms include prolonged coma, seizures, falls or immobility, and electrolyte disturbances; our patient had none of these [10]. Thus, it is likely that our case was complicated by ischemia and direct toxic effects of alcohol on the skeletal muscles.…”

Section: Discussionmentioning

confidence: 95%

“…The rhabdomyolysis is treated by aggressive fluid hydration to maintain a urine output of 200-300 ml/hour in the first 24 hours. The urine pH should be kept above 6.5 to avoid precipitation of myoglobin in the renal tubules [10]. Although we were able to obtain the above objectives with intravenous normal saline and sodium bicarbonate respectively, the patient required two sessions of renal replacement therapy for worsening acidosis and hyperkalemia that had to be rectified before surgery for his aortic thrombus.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Acute Abdominal Aorta Thrombosis and Ischemic Rhabdomyolysis Secondary to Severe Alcohol Intoxication

Abideen

Abbas

Farooq

et al. 2016

Cureus

View full text Add to dashboard Cite

Acute alcohol intoxication is a common cause of emergency visits worldwide. Although moderate alcohol consumption is protective against coronary artery disease, binge drinking is associated with adverse cardiovascular and neurological outcomes and may even cause sudden death. Although, few past accounts of venous thrombosis with alcohol binge drinking are available, arterial thrombosis with the condition has never been reported in the literature. We present the unusual case of a young Afghan male, who presented to us with painful, tender and swollen legs three days after a heavy alcohol binge on a Saturday night. He was diagnosed as a case of acute limb ischemia secondary to massive abdominal aorta and bilateral femoral artery thrombosis. He also had acute renal failure secondary to rhabdomyolysis. Cardiac workup revealed new onset paroxysmal atrial fibrillation and a large thrombus in the left ventricular cavity. His blood ethanol level was high. He was treated by a multidisciplinary team; urgent surgical thrombectomy for thrombotic complications, intravenous fluid hydration and later renal replacement therapy for acute renal failure. To the best of our knowledge, such a constellation of clinical features in association with severe acute alcohol intoxication has not been reported in the literature. We believe, the procoagulant nature of high blood ethanol levels and the onset of atrial fibrillation after the heavy alcohol binge, known as the holiday heart syndrome, precipitated the thrombotic events leading to rhabdomyolysis and acute renal failure. Through this case, we conclude that a very heavy alcohol binge may cause thrombotic occlusion of the abdominal aorta and femoral arteries resulting in ischemic rhabdomyolysis and acute renal failure. A high index of suspicion must be kept, especially for a patient presenting with tender, swollen lower limbs and acute renal failure after an alcohol binge.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Abdominal Aorta Thrombosis and Ischemic Rhabdomyolysis Secondary to Severe Alcohol Intoxication

Abideen

Abbas

Farooq

et al. 2016

Cureus

View full text Add to dashboard Cite

show abstract

“…The patient was a college student and stated that she was a social drinker, which makes it possible that acute alcohol use in the days surrounding her spinning class contributed to the development of TCS [9]. Additionally, this was her first spinning class, and she stated that the intensity of the exercise was outside of her normal level of activity.…”

Section: Discussionmentioning

confidence: 99%

“…Irregular high-intensity exercise, combined with potential stressors, such as alcohol use, may have led to rhabdomyolysis, edema, and increased compartment pressure that resulted in TCS. Other possible genetic and environmental factors, such as adenosine triphosphate deficiency, hyper-/hypothyroidism, or malnutrition, may play a role in predisposing certain patients to exertional TCS [9]. …”

Section: Discussionmentioning

confidence: 99%

Spinning Out of Control: A 19-Year-Old Female with Spinning-Related Exertional Thigh Compartment Syndrome

Gould

Badash

Han

et al. 2016

Cureus

View full text Add to dashboard Cite

Thigh compartment syndrome (TCS) is a rare condition caused by high pressures within the fascial compartments of the thigh, impeding capillary flow and leading to decreased perfusion, tissue hypoxia, and necrosis. TCS is most frequently associated with trauma and anticoagulation but has also rarely been associated with exercise-related injury. We present the case of a 19-year-old female who reported painful swelling in her thighs and darkening of her urine after participating in a spinning class. On physical examination, the patient was found to have tight, painful thigh compartments with extreme tenderness on passive motion. Labs revealed a marked elevation of creatine kinase and leukocytosis. The patient was diagnosed with TCS and underwent emergent decompression fasciotomy and aggressive IV fluids for protection against myoglobinuria. Due to high clinical suspicion, prompt diagnosis, and early surgery, the patient experienced excellent recovery without functional deficits.

show abstract

Breast cancer, alcohol, and phosphate toxicity

Brown

Bigelow

Dubin

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

Alcohol consumption is associated with an increased risk of breast cancer, even at low alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol intake is low. Furthermore, the causative mechanisms underlying alcohol's association with breast cancer are unknown. The present theoretical paper uses a modified grounded theory method to review the research literature and propose that alcohol's association with breast cancer is mediated by phosphate toxicity, the accumulation of excess inorganic phosphate in body tissue. Serum levels of inorganic phosphate are regulated through a network of hormones released from the bone, kidneys, parathyroid glands, and intestines. Alcohol burdens renal function, which may disturb the regulation of inorganic phosphate, impair phosphate excretion, and increase phosphate toxicity. In addition to causing cellular dehydration, alcohol is an etiologic factor in nontraumatic rhabdomyolysis, which ruptures cell membranes and releases inorganic phosphate into the serum, leading to hyperphosphatemia. Phosphate toxicity is also associated with tumorigenesis, as high levels of inorganic phosphate within the tumor microenvironment activate cell signaling pathways and promote cancer cell growth. Furthermore, phosphate toxicity potentially links cancer and kidney disease in onco‐nephrology. Insights into the mediating role of phosphate toxicity may lead to future research and interventions that raise public health awareness of breast cancer risk and alcohol consumption.

show abstract

Nontraumatic rhabdomyolysis with short‐term alcohol intoxication – a case report

Cited by 25 publications

References 22 publications

Acute Abdominal Aorta Thrombosis and Ischemic Rhabdomyolysis Secondary to Severe Alcohol Intoxication

Acute Abdominal Aorta Thrombosis and Ischemic Rhabdomyolysis Secondary to Severe Alcohol Intoxication

Spinning Out of Control: A 19-Year-Old Female with Spinning-Related Exertional Thigh Compartment Syndrome

Breast cancer, alcohol, and phosphate toxicity

Contact Info

Product

Resources

About