Acute respiratory distress syndrome: Frequency, clinical course, and costs of care

Valta, Päivi; Uusaro, Ari; Nunes, Silvia; Ruokonen, Esko; Takala, Jukka

doi:10.1097/00003246-199911000-00008

Cited by 127 publications

(83 citation statements)

References 28 publications

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“…One of the most frequently studied indices is the Pa,O 2 / FI,O 2 , although contradictory results concerning its ability to predict outcome have been reported in adult AHRF/ARDS [2,[27][28][29][30][31][32][33][34][35]. Some authors have argued that the ratio may not be predictive at inclusion, but after 24 or 48 h [30,31].…”

Section: Discussionmentioning

confidence: 99%

Incidence and short-term outcome of acute lung injury in mechanically ventilated children

Dahlem¹,

Aalderen²,

Hamaker³

et al. 2003

Eur Respir J

114

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The aim of this study was to determine the incidence and short-term outcome of mechanically ventilated children suffering from acute lung injury (ALI) on a paediatric intensive care unit (PICU).Between January 1 1998 and January 1 2000, all mechanically ventilated children were evaluated using the criteria of an American-European Consensus Conference.Of the 443 children eligible for analysis, 44 (9.9%) were diagnosed as suffering from ALI. Of these, 79.5% developed the acute respiratory distress syndrome (ARDS); 54.5% (24 of 44) fulfilled the ARDS criteria at inclusion and 25% (11 of 44) later. PICU mortality for ALI was 27.3% (12 of 44) and within the ARDS subgroup 31.4% (11 of 35). Of the 12 children who died, 11 had ARDS; the main cause of death was cerebral damage (seven of 12).Acute lung injury and acute respiratory distress syndrome are rare diseases on apaediatric intensive care unit with a high mortality. Most of the children with acutelung injury develop acute respiratory distress syndrome. In the acute respiratory distress syndrome subgroup, mortality is higher than in the acute lung injury nonacute respiratory distress syndrome subgroup. Further investigations should confirm prognostic factors (e.g.respiratory parameters) for prediction of outcome.

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Section: Discussionmentioning

confidence: 99%

Incidence and short-term outcome of acute lung injury in mechanically ventilated children

Dahlem¹,

Aalderen²,

Hamaker³

et al. 2003

Eur Respir J

114

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“…In addition, our findings strongly suggest that changes in the Ang-Tie2 system, together with elevated VEGF expression, are involved in the development of VILI (figure 4) (Hegeman et al, 2010). An intriguing clinical observation is that most critically ill ALI/ARDS patients do not succumb to acute lung failure but rather to progressive non-pulmonary organ dysfunction, so-called MOF (Ferring & Vincent, 1997;Montgomery et al, 1985;Valta et al, 1999). In this respect, we showed that mechanical ventilation with high pressures increased the pro-inflammatory state of the lung but also of the liver and kidney (figure 1) (Hegeman et al, 2009).…”

Section: Discussionmentioning

confidence: 73%

“…An important clinical observation is that most ventilated critically ill patients do not succumb to acute respiratory failure but rather to progressive multiple organ failure (MOF) (Ferring & Vincent, 1997;Montgomery et al, 1985;Valta et al, 1999). A definition of MOF has been provided by John Marshall, who defined it as "the development of potentially reversible physiologic derangement involving two or more organ systems not involved in the disorder that resulted in ICU admission, and arising in the wake of a potentially lifethreatening physiologic insult" (Marshall, 2001).…”

Section: Local Versus Systemic Inflammationmentioning

confidence: 99%

Ventilator-Induced Lung Injury: Mechanisms and Future Therapeutic Interventions

Hegeman¹,

Schultz²,

Heijnen³

et al. 2012

Front Lines of Thoracic Surgery

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“…Although the prevalence is between 1 to 15 percent, but its association with increased mortality risk for these patients is approximately 78% [1].…”

Section: Introductionmentioning

confidence: 99%

“…Respiratory failure and invasive treatments such as mechanical ventilation can lead to worsening renal failure, increased mortality, and increased length of stay in the hospital [3]. Valta et al (1999) conducted a study and showed that among 50 children who were bedridden in PICU under mechanical ventilation, 12.8 percent of them had creatinine increase 1.5 times more than the amount before ventilation after 24 hours.…”

Section: Introductionmentioning

confidence: 99%

Changes in Renal Indices among Children under Mechanical Ventilation

2013

J of clin res gov

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Ab s t r a c tPurpose:To compare renal indices in patients under mechanical ventilation and controls not undergoing the procedure.Methods:In this comparative study, the authorsdetermined and compared levels of serum creatinine, urine volume and glumerular filtration rate(GFR) in a group of 80 patientsunder mechanical ventilation and a control group of 50 patients admitted in the pediatric intensive care unit(PICU) at Tabriz Children's Hospital.Results:Urine volume in 16% of patients in the mechanical ventilation patient group was less than 0.3ml/kg/h (based onRIFLE formula) while in the control group, there was no decrease in urine volume and there was a significant difference between the two groups. Creatinine levels greater than 3 times normal size, was found in both groups and in mechanical ventilation group 3.7% of the patients had an increased amount of creatinine while there was no statistically significant difference between the two groups. Increased creatinine levels in the mechanical ventilation group, was in the range of previous studies. All patients in the mechanical ventilation group with a decrease in GFR above 75%, died. Conclusion:Critically ill children admitted to PICU undergoing mechanical ventilation are at risk of acute renal failure and changes in urine volume could be used as an alerting measure for acute renal failure in these patients.

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Acute respiratory distress syndrome: Frequency, clinical course, and costs of care

Cited by 127 publications

References 28 publications

Incidence and short-term outcome of acute lung injury in mechanically ventilated children

Incidence and short-term outcome of acute lung injury in mechanically ventilated children

Ventilator-Induced Lung Injury: Mechanisms and Future Therapeutic Interventions

Changes in Renal Indices among Children under Mechanical Ventilation

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