Acute Respiratory Failure in Adult Patients with Dengue Virus Infection

Wang, Chin‐Chou; Liu, Shih-Feng; Liao, Shang-Chih; Lee, Ing-Kit; Liu, Jien-Wei; Lin, An‐Shen; Wu, Chen-Hsuan; Chung, Yoon Kyu; Lin, Meng-Chih

doi:10.4269/ajtmh.2007.77.151

Cited by 58 publications

(48 citation statements)

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“…The respiratory and cardiovascular components of the SOFA score have been reported to be better predictors than other components of the SOFA score in one ROC analysis [23]. In accordance with a previous study [36], the causes of respiratory failure were diverse in our cohort, and some cases were intubated due to clinical concerns of volume overload during fluid resuscitation. In the Cox model, although respiratory failure indicative of a deterioration of clinical status and dysregulation in respiratory function, at ICU admission, was marginally significant, respiratory failure still remains to be an important prognostic factor.…”

Section: Discussionsupporting

confidence: 86%

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A Cohort Study of Adult Patients with Severe Dengue in Taiwanese Intensive Care Units: The Elderly and APTT Prolongation Matter for Prognosis

et al. 2017

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BackgroundThere was a large dengue outbreak in Taiwan in 2015, in which the ages of the affected individuals were higher than those in other countries. The aim of this study was to explore the characteristics and prognostic factors for adults with severe dengue in intensive care units (ICUs).MethodsAll adults admitted to ICUs with dengue virus infection (DENV) at a medical center from July 1, 2015 to December 31, 2015 were enrolled. DENV was diagnosed by the presence of serum NS1 antigen, IgM antibodies to dengue virus, or dengue virus RNA by real-time reverse transcriptase polymerase chain reaction. Demographic data, clinical features, and lab data were collected, and a multivariate Cox model was used to identify the predictive factors for in-hospital mortality.ResultsSeventy-five patients admitted to ICUs with laboratory-confirmed DENV were enrolled (mean age 72.3±9.3 years). The most common comorbidities included hypertension (72.0%), diabetes (43.7%), and chronic kidney disease (22.7%). The in-hospital case fatality rate (CFR) was 41.3%. The patients who died were predominantly female, had higher disease severity at ICU admission, shorter ICU/hospital stay, longer initial activated partial thromboplastin time (APTT), and higher initial serum aspartate transaminase levels. Cardiac arrest before ICU admission (hazard ratio [HR]: 6.26 [1.91–20.54]), prolonged APTT (>48 seconds; HR: 3.91 [1.69–9.07]), and the presence of acute kidney injury on admission (HR: 2.48 [1.07–5.74]), were independently associated with in-hospital fatality in the Cox multivariate analysis.ConclusionDuring the 2015 dengue outbreak in Taiwan, the patients with severe dengue in ICUs were characterized by old age, multiple comorbidities, and a high CFR. Organ failure (including cardiac failure, and renal failure) and coagulation disturbance (prolongation of initial APTT) were independent predictive factors for in-hospital fatality.

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Section: Discussionsupporting

confidence: 86%

“…More than 70% of our patients received mechanical ventilation, which had been associated with a poor prognosis in the literature [36, 37]. The respiratory and cardiovascular components of the SOFA score have been reported to be better predictors than other components of the SOFA score in one ROC analysis [23].…”

Section: Discussionmentioning

confidence: 99%

A Cohort Study of Adult Patients with Severe Dengue in Taiwanese Intensive Care Units: The Elderly and APTT Prolongation Matter for Prognosis

et al. 2017

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“…There have been reports of cases with bloody pleural effusion. [6][7][8] However, in this case, the patient presented at the end of febrile phase. And as he went through his critical phase he developed pleural effusion which was found to be hemothorax.…”

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confidence: 87%

Unprovoked hemothorax : an unusual presentation in Dengue Haemorrhagic Fever

Manappallil

2016

Asian J Med Sci

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A B S T R A C TAccording to WHO, Dengue fever (DF) is the most rapidly spreading mosquito-borne viral disease in the world. Dengue Haemorrhagic fever (DHF) is a severe and more serious form of DF, characterised by fever, bleeding manifestations, plasma leakage and thrombocytopenia. This is a case of a 28 year old male, who presented with history of fever and myalgia and was diagnosed to have DF. He had developed acute onset dyspnoea and his chest X-Ray showed right sided pleural effusion. Pleurocentesis revealed haemorrhagic fluid in the absence of trauma.Unprovoked hemothorax as an initial presentation of DHF has rarely been reported.

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“…Mikroorganisme tersebut tumbuh baik dari kultur darah, cairan serebrospinal, urin, maupun sputum. 20 Keterlibatan ginjal dapat berupa peningkatan kadar kreatinin serum, gagal ginjal akut, nekrosis tubular akut, sindrom uremikum hemolitik, proteinuria, glomerulopati, dan sindrom nefrotik. 21,22 Gagal ginjal akut terlihat pada mayoritas pasien dengan kadar kreatinin lebih tinggi pada kelompok yang meninggal.…”

Section: Pembahasanunclassified

Profil Klinis dan Laboratoris Ensefalopati Dengue pada Anak di RSUP Dr. Sardjito

Dhevianty¹,

Arguni²,

Triono³

2017

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Latar belakang. Ensefalopati dengue merupakan manifestasi neurologis infeksi dengue yang paling sering. Belum banyak penelitian yang menjelaskan gambaran ensefalopati dengue pada anak. Tujuan. Mengetahui gambaran klinis dan laboratoris anak dengan ensefalopati dengue. Metode. Penelitian menggunakan metode retrospektif. Data diambil dari rekam medis anak (1-18 tahun) dengan ensefalopati dengue dengan luaran hidup maupun meninggal yang dirawat di RSUP Dr. Sardjito sejak Januari 2010 hingga Desember 2016. Manifestasi yang diamati adalah perdarahan gastrointestinal, kejang, syok, hepatitis akut, gagal ginjal akut, pemanjangan prothrombin time (PT), activated partial thromboplastin time (APTT), kadar hematokrit, leukosit, dan trombosit. Rekam medis anak dengan riwayat gangguan fungsi ginjal, hati, dan koagulasi serta rekam medis yang tidak lengkap dieksklusi. Analisis data dengan uji independent t-test atau Mann Whitney. Hasil. Terdapat 81 anak dengan ensefalopati dengue dan 25 di antaranya meninggal. Mayoritas anak menunjukkan manifestasi perdarahan gastrointestinal, syok, sepsis, hepatitis ringan, dan gagal ginjal akut. Profil laboratoris memperlihatkan peningkatan SGOT yang lebih tinggi dari SGPT, pemanjangan PT dan kadar kreatinin yang lebih tinggi pada kelompok meninggal. Kesimpulan. Kelainan ensefalopati pada infeksi dengue merupakan suatu kondisi yang serius dengan angka kematian yang tinggi (30.86%). Perdarahan gastrointestinal, syok, sepsis, hepatitis ringan, gagal ginjal akut pada mayoritas pasien. Pemanjangan PT dan kadar kreatinin lebih tinggi pada kelompok meninggal. Sari Pediatri 2017;18(6):423-9Kata kunci: ensefalopati, dengue, anak, klinis, laboratoris Clinico-Laboratory Profile of Children with Dengue Encephalopathy at Sardjito HospitalAfiarina Dhevianty, Eggi Arguni, Agung Triono Background. Dengue encephalopathy is the most often neurological manifestation of dengue infection. Even though rare, this complication has high mortality rate. There was limited study about encephalopathy in children. Objective. To investigate clinical and laboratory profile of children with dengue encephalopathy. Methods. Retrospective study. Data were collected from medical records of children (1-18 years old) with dengue encephalopathy who were hospitalized at Sardjito Hospital Yogyakarta from Januari 2010 throughDesember 2016. Gastrointestinal bleeding, seizure, sepsis, shock, acute hepatitis, acute kidney injury, hematocrit, thrombocyte, leukocyte, prolonged prothrombine time and activated partial thromboplastin time were studied as clinical and laboratory profile. Outcome were classified as survive and death. The exclusion criteria were children with underlying kidney diseases, liver diseases, bleeding/coagulation disorders and incomplete medical records. Statistical analysis used independent t-test or Mann Whitney. Results. There were 81 children with dengue encepalopathy, 25 of them died. Most of patient showed gastrointestinal bleeding, sepsis, shock, mild acute hepatitis, acute kidney injury, prolonged prothrombi...

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Acute Respiratory Failure in Adult Patients with Dengue Virus Infection

Cited by 58 publications

References 29 publications

A Cohort Study of Adult Patients with Severe Dengue in Taiwanese Intensive Care Units: The Elderly and APTT Prolongation Matter for Prognosis

A Cohort Study of Adult Patients with Severe Dengue in Taiwanese Intensive Care Units: The Elderly and APTT Prolongation Matter for Prognosis

Unprovoked hemothorax : an unusual presentation in Dengue Haemorrhagic Fever

Profil Klinis dan Laboratoris Ensefalopati Dengue pada Anak di RSUP Dr. Sardjito

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