Acute Retinal Necrosis

Lau, Chun Ho; Missotten, Tom; Salzmann, Joël; Lightman, Susan

doi:10.1016/j.ophtha.2006.08.037

Cited by 260 publications

(169 citation statements)

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“…The clinical diagnosis is frequently supported by the identification of the causative infectious agent, most commonly varicella-zoster virus (VZV), though herpes simplex virus (HSV) types 1 and 2, cytomegalovirus, and Epstein-Barr virus (EBV) have also been implicated 1,2 .…”

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confidence: 99%

“…There are only a few reported cases of EBV-associated ARN 1,2,5 and all lack definitive demonstration of the virus. Epstein-Barr virus DNA has been previously detected by polymerase chain reaction (PCR) in vitreous samples of patients with ARN, but only in conjunction with VZV DNA 1,2 .…”

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confidence: 99%

“…Epstein-Barr virus DNA has been previously detected by polymerase chain reaction (PCR) in vitreous samples of patients with ARN, but only in conjunction with VZV DNA 1,2 . Herein, we describe a case of ARN in which EBV was the sole virus detected both by vitreous PCR and, most importantly, by molecular pathology (microdissection and PCR) confirming the virus within the retina of the enucleated globe.…”

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Acute Retinal Necrosis Associated With Epstein-Barr Virus

et al. 2014

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cute retinal necrosis (ARN) is a syndrome characterized by progressive intraretinal inflammation and necrosis. The clinical diagnosis is frequently supported by the identification of the causative infectious agent, most commonly varicella-zoster virus (VZV), though herpes simplex virus (HSV) types 1 and 2, cytomegalovirus, and Epstein-Barr virus (EBV) have also been implicated. 1,2 Epstein-Barr virus, a double-stranded DNA virus transmitted by oral secretions, infects more than 90% of humans. 3 IMPORTANCE Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN.OBSERVATIONS Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology.CONCLUSIONS AND RELEVANCE Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

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Acute Retinal Necrosis Associated With Epstein-Barr Virus

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“…[7,8] The antiviral property of silicone oil is not reported in the literature. There are three reports on ARN successfully treated by vitrectomy combined with silicone oil filling, which do not address the effects of silicone oil on antiviral growth [5,6,7].…”

Section: Discussionmentioning

confidence: 99%

Experimental study on antiviral activity of silicone oil in vitro

Yan

2008

Graefes Arch Clin Exp Ophthalmol

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“…Progression of retinitis can be commonly controlled within 2–4 weeks, when immediate treatment is instilled. When the acute course has subsided, retinal thinning and atrophy remains with often sharply demarked areas predisposing for retinal breaks 59,60. Additional inflamed vitreous organization results in proliferative vitreoretinopathy.…”

Section: Herpes Virus-associated Posterior Uveitismentioning

confidence: 99%

Current aspects on the management of viral uveitis in immunocompetent individuals

Pleyer

Chee

2015

OPTH

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Viruses are a fundamental etiology of ocular inflammation, which may affect all structures of the organ. Advances in molecular diagnostics reveal an increasingly broader spectrum of virus-associated intraocular inflammation, including all members of the herpes family, rubella virus, and other more rare causes such as Epstein–Barr and chikungunya virus. In particular, viruses of the herpes family are important causes of anterior and posterior uveitis. Owing to their often fulminant clinical course and persistence in ocular tissues, a clear differential diagnosis between alpha- and beta-type herpes viruses is essential to guide acute and long-term treatment. Here, we review the epidemiology, clinical, and laboratory findings of virus-associated uveitis with emphasis on their therapy and management and include our own experience.

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Acute Retinal Necrosis

Cited by 260 publications

References 50 publications

Acute Retinal Necrosis Associated With Epstein-Barr Virus

Acute Retinal Necrosis Associated With Epstein-Barr Virus

Experimental study on antiviral activity of silicone oil in vitro

Current aspects on the management of viral uveitis in immunocompetent individuals

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