Acute Sensorineural Deafness in Lassa Fever

Cummins, David; McCormick, Joseph B.; Bennett, Diane; Samba, James A.; Farrar, Bertha B.; Machin, Samuel J.; Fisher‐Hoch, Susan P.

doi:10.1001/jama.1990.03450160063030

Cited by 171 publications

(99 citation statements)

References 13 publications

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“…About 20% have acute, transient sensorineural deafness at the time of systemic clinical improvement. Complications include meningitis, encephalitis, seizures, and transient or permanent sensorineural deafness (Cummins et al, 1990;Solbrig and McCormick, 1991;Liao et al, 1992). Survivors can have persistent cerebellar ataxia as well as unilateral or bilateral deafness.…”

Section: Lassa Fevermentioning

confidence: 99%

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Wilson¹,

Peters²

2014

Neurovirology

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Section: Lassa Fevermentioning

confidence: 99%

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Wilson¹,

Peters²

2014

Neurovirology

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“…In survivors, in contrast, symptoms disappear 10 to 15 days after onset, although about one-third of survivors may suffer from deafness, a common complication of LF (22). LV infection in humans seems to be controlled primarily by T-cell responses.…”

mentioning

confidence: 98%

Human Dendritic Cells Infected with the Nonpathogenic Mopeia Virus Induce Stronger T-Cell Responses than Those Infected with Lassa Virus

Pannetier¹,

Reynard²,

Russier³

et al. 2011

J Virol

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The events leading to death in severe cases of Lassa fever (LF) are unknown. Fatality seems to be linked to high viremia and immunosuppression, and cellular immunity, rather than neutralizing antibodies, appears to be essential for survival. We previously compared Lassa virus (LV) with its genetically close but nonpathogenic homolog Mopeia virus (MV), which was used to model nonfatal LF. We showed that strong and early activation of antigen-presenting cells (

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“…In surviving patients, symptoms disappear 10 -15 days after onset (7). However, deafness is a common complication of Lassa fever, affecting about one-third of survivors (8). Macrophages (MP) and endothelial cells are the main targets for LV (9).…”

mentioning

confidence: 99%

Lassa Virus Infection of Human Dendritic Cells and Macrophages Is Productive but Fails to Activate Cells

Baize

Kaplon

Faure

et al. 2004

The Journal of Immunology

192

208

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Lassa fever is a hemorrhagic fever caused by Lassa virus (LV), an old-world Arenavirus. Little is known about the immune responses that occur during the disease, but protection seems to be linked to the induction of cellular responses specific for viral glycoproteins. Conversely, severe Lassa fever may be associated with immunosuppression. We studied the infection of human dendritic cells (DC) and macrophages (MP) by LV. Both these cell types are susceptible to LV infection. Viral nucleoprotein was detected in DC and MP, and high and moderate viral titers were obtained with culture supernatants of DC and MP, respectively. LV did not induce apoptosis in DC and MP. These cells were not activated by LV infection. No change was observed in the expression of surface molecules involved in activation, costimulation, adhesion, and Ag presentation following LV infection, or in the functional properties of DC. Inflammatory cytokine production was not detected at the mRNA or protein level after LV infection of DC and MP. Thus, MP, and particularly DC, are crucial targets for LV and are probably involved in the early replication of LV from the initial site of infection. The lack of activation and maturation of cells following infection may be associated with the immunosuppression observed in severe LV infection.

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Acute Sensorineural Deafness in Lassa Fever

Cited by 171 publications

References 13 publications

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

Human Dendritic Cells Infected with the Nonpathogenic Mopeia Virus Induce Stronger T-Cell Responses than Those Infected with Lassa Virus

Lassa Virus Infection of Human Dendritic Cells and Macrophages Is Productive but Fails to Activate Cells

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