Acute sleep deprivation in humans

Casale, Courtney; Brieva, Tess; Yamazaki, Erika; Antler, Caroline; Goel, Namni

doi:10.1016/b978-0-12-822963-7.00005-0

Cited by 2 publications

(4 citation statements)

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“…Chronic sleep deprivation is an important public health concern associated with many adverse health outcomes and clinical disorders such as anxiety, depression, immune dysfunction, Alzheimer’s disease, cardiovascular disease, obesity, cancer, and overall morbidity and mortality ( Ferrie et al, 2007 ; Gallicchio and Kalesan, 2009 ; Mullington et al, 2009 ; Phan and Malkani, 2019 ; Al-Rashed et al, 2021 ). Sleep deprivation is a potent stressor generally resulting in marked increases in physiological sleepiness (e.g., the Maintenance of Wakefulness Test and the Multiple Sleep Latency Test) and subjective sleepiness [e.g., the Karolinska Sleepiness Scale (KSS)] and significant deficits in cognitive performance ( Banks and Dinges, 2007 ; Goel et al, 2009 ; Casale et al, 2021a , b ; Yamazaki et al, 2021a , b ). However, a number of studies show there are robust and highly replicable phenotypic individual differences in response to repeated exposure to sleep deprivation: some individuals are resilient, and others are vulnerable to total sleep deprivation (TSD) and chronic sleep restriction (SR), both commonly experienced types of sleep loss ( Van Dongen et al, 2004 ; Goel et al, 2009 ; Dennis et al, 2017 ; Yamazaki and Goel, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Cortisol and C-Reactive Protein Vary During Sleep Loss and Recovery but Are Not Markers of Neurobehavioral Resilience

et al. 2021

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Cortisol and C-reactive protein (CRP) typically change during total sleep deprivation (TSD) and psychological stress; however, it remains unknown whether these biological markers can differentiate robust individual differences in neurobehavioral performance and self-rated sleepiness resulting from these stressors. Additionally, little is known about cortisol and CRP recovery after TSD. In our study, 32 healthy adults (ages 27–53; mean ± SD, 35.1 ± 7.1 years; 14 females) participated in a highly controlled 5-day experiment in the Human Exploration Research Analog (HERA), a high-fidelity National Aeronautics and Space Administration (NASA) space analog isolation facility, consisting of two baseline nights, 39 h TSD, and two recovery nights. Psychological stress was induced by a modified Trier Social Stress Test (TSST) on the afternoon of TSD. Salivary cortisol and plasma CRP were obtained at six time points, before (pre-study), during [baseline, the morning of TSD (TSD AM), the afternoon of TSD (TSD PM), and recovery], and after (post-study) the experiment. A neurobehavioral test battery, including measures of behavioral attention and cognitive throughput, and a self-report measure of sleepiness, was administered 11 times. Resilient and vulnerable groups were defined by a median split on the average TSD performance or sleepiness score. Low and high pre-study cortisol and CRP were defined by a median split on respective values at pre-study. Cortisol and CRP both changed significantly across the study, with cortisol, but not CRP, increasing during TSD. During recovery, cortisol levels did not return to pre-TSD levels, whereas CRP levels did not differ from baseline. When sex was added as a between-subject factor, the time × sex interaction was significant for cortisol. Resilient and vulnerable groups did not differ in cortisol and CRP, and low and high pre-study cortisol/CRP groups did not differ on performance tasks or self-reported sleepiness. Thus, both cortisol and CRP reliably changed in a normal, healthy population as a result of sleep loss; however, cortisol and CRP were not markers of neurobehavioral resilience to TSD and stress in this study.

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Section: Introductionmentioning

confidence: 99%

Cortisol and C-Reactive Protein Vary During Sleep Loss and Recovery but Are Not Markers of Neurobehavioral Resilience

et al. 2021

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“…Notably, there have been no other studies that have investigated the effects of REC sleep on CV indices following TSD. Beyond CV measures, numerous studies have shown that REC sleep after TSD reduced fatigue and sleep propensity, improved neurobehavioral performance, enhanced mood, and returned C‐reactive protein, delta power, and brain age to BL levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Chu et al., 2023 ; Drummond et al., 2006 ; Goldschmied et al., 2023 ; Mantua et al., 2020 ; Stroemel‐Scheder et al., 2020 ; Yamazaki, Antler, Casale, et al., 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ). In contrast, REC sleep did not completely reverse the detrimental effects of sleep deprivation on cortisol levels, behavioral attention, and self‐rated vigor levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Yamazaki, Antler, Casale, et al., 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Beyond CV measures, numerous studies have shown that REC sleep after TSD reduced fatigue and sleep propensity, improved neurobehavioral performance, enhanced mood, and returned C‐reactive protein, delta power, and brain age to BL levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Chu et al., 2023 ; Drummond et al., 2006 ; Goldschmied et al., 2023 ; Mantua et al., 2020 ; Stroemel‐Scheder et al., 2020 ; Yamazaki, Antler, Casale, et al., 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ). In contrast, REC sleep did not completely reverse the detrimental effects of sleep deprivation on cortisol levels, behavioral attention, and self‐rated vigor levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Yamazaki, Antler, Casale, et al., 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ). Discrepancies in how effectively REC sleep restores functions to BL levels may be due to the number of REC sleep days employed, variations in the amount of TIB utilized for REC sleep, or interindividual differences, since differential vulnerability to TSD can affect the amount of REC sleep needed for some facets of functioning to return to BL levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, REC sleep did not completely reverse the detrimental effects of sleep deprivation on cortisol levels, behavioral attention, and self‐rated vigor levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Yamazaki, Antler, Casale, et al., 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ). Discrepancies in how effectively REC sleep restores functions to BL levels may be due to the number of REC sleep days employed, variations in the amount of TIB utilized for REC sleep, or interindividual differences, since differential vulnerability to TSD can affect the amount of REC sleep needed for some facets of functioning to return to BL levels (Casale et al., 2023 ; Casale & Goel, 2021 ; Yamazaki, Antler, Lasek, & Goel, 2021 ). Therefore, it is important to further investigate the extent to which REC sleep can completely restore the adverse effects of TSD on CV measures.…”

Section: Discussionmentioning

confidence: 99%

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Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

Pasetes,

Rosendahl‐Garcia,

Goel

2023

Physiological Reports

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Since short sleep duration adversely affects cardiovascular (CV) health, we investigated the effects of exposures to total sleep deprivation (TSD), and baseline (BL) and recovery (REC) sleep on CV measures. We conducted a 5‐day experiment at months 2 and 4 in two separate studies (N = 11 healthy adults; 5 females). During these repeated experiments, CV measures [stroke volume (SV), cardiac index (CI), systemic vascular resistance index (SVRI), left ventricular ejection time, heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) and mean arterial pressure (MAP)] were collected at three assessment time points after: (1) two BL 8 h time‐in‐bed (TIB) sleep opportunity nights; (2) a TSD night; and (3) two REC 8‐10 h TIB nights. CV measures were also collected pre‐study. TSD significantly increased SV and CI, and decreased SVRI, with large effect sizes, which importantly were reversed with recovery, indicating these measures are possible novel biomarkers for assessing the adverse consequences of TSD. Pre‐study SV, CI, SVRI, HR, SBP, and MAP measures also significantly associated with TSD CV responses at months 2 and 4 [Pearson's r: 0.615–0.862; r2: 0.378–0.743], indicating they are robust correlates of future TSD CV responses. Our novel findings highlight the critical impact of sleep on CV health across time.

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Acute sleep deprivation in humans

Cited by 2 publications

References 171 publications

Cortisol and C-Reactive Protein Vary During Sleep Loss and Recovery but Are Not Markers of Neurobehavioral Resilience

Cortisol and C-Reactive Protein Vary During Sleep Loss and Recovery but Are Not Markers of Neurobehavioral Resilience

Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

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