2020
DOI: 10.1038/s41593-020-00742-z
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Acute social isolation evokes midbrain craving responses similar to hunger

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Cited by 183 publications
(118 citation statements)
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“…Three studies of ventral striatum response to social images produced divergent results [ 25 , 34 , 62 ]. A recently published fMRI study (published past our cutoff date) reported similar activation in substantia nigra/ventral tegmental area (SN/VTA) among young adults undergoing either 10 h of social isolation or fasting from food [ 75 ], supporting loneliness as a state that motivates one to seek social interaction, much like hunger motivates one to seek food. Interestingly, lonely participants had less activation in the SN/VTA.…”
Section: Discussionmentioning
confidence: 99%
“…Three studies of ventral striatum response to social images produced divergent results [ 25 , 34 , 62 ]. A recently published fMRI study (published past our cutoff date) reported similar activation in substantia nigra/ventral tegmental area (SN/VTA) among young adults undergoing either 10 h of social isolation or fasting from food [ 75 ], supporting loneliness as a state that motivates one to seek social interaction, much like hunger motivates one to seek food. Interestingly, lonely participants had less activation in the SN/VTA.…”
Section: Discussionmentioning
confidence: 99%
“…Social contact is important for a healthy cognitive, emotional, endocrine and immune development in humans [ 28 ]. It has even been reported that humans can feel a craving for social contact similar to that of food [ 29 ]. In addition to the reduced social contact, the societal lock-down was also accompanied by economic decline and a compromised healthcare system.…”
Section: Discussionmentioning
confidence: 99%
“…From an evolutionary perspective, loneliness may have evolved to motivate the formation of new social relationships, in the same way as hunger induces scavenging. [7-9] However, when the connection with other individuals fails, loneliness impairs inflammatory and immune responses [6,10] and promotes a phenotypic hypersensitivity to social threats and self-centered behavior. [8,11] The perception of the social environment as threatening may lead to various negative biases in loneliness.…”
Section: Introductionmentioning
confidence: 99%