Acute superior mesenteric vein thrombosis in the setting of cytomegalovirus mononucleosis: a case report and review of the literature

Walter, Graham; Richert, Quinlan; Ponnampalam, Arjuna; Sharma, Aditya

doi:10.1016/s1473-3099(20)30782-9

Cited by 6 publications

(10 citation statements)

References 18 publications

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“…Moreover, we first confirmed the causal association between genetic predisposition of anti-CMV IgG level and DVT, a thrombotic disorder of the veins with a higher risk for life-threatening PE. Although with the limited investigation, several case reports or case series have revealed a trend for correlation between CMV infection and venous thrombosis-related diseases such as venous thromboembolism (VTE; the combination of DVT and PE) ( Ceccarelli et al., 2018 ), portal vein thrombosis ( Squizzato et al., 2007 ), and superior mesenteric vein thrombosis ( Walter et al., 2021 ). Additionally, case–control studies observed a higher incidence rate of thrombosis in the CMV infection group (6.4% vs. 0%) ( Atzmony et al., 2010 ) and a higher rate of anti-CMV IgG positivity in the VTE group compared with healthy controls ( Schimanski et al., 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Tan

Ren²,

Fan³

et al. 2022

Front. Cell. Infect. Microbiol.

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BackgroundAccumulating evidence has indicated that persistent human cytomegalovirus (HCMV) infection is associated with several cardiovascular diseases including atherosclerosis and coronary artery disease. However, whether there is a causal association between the level of anti-HCMV immune response and the risk of cardiovascular diseases remains unknown.MethodsSingle-nucleotide polymorphisms associated with anti-cytomegalovirus immunoglobulin (Ig) G levels were used as instrumental variables to estimate the causal effect of anti-cytomegalovirus IgG levels on 9 cardiovascular diseases (including atrial fibrillation, coronary artery disease, hypertension, heart failure, peripheral artery disease, pulmonary embolism, deep vein thrombosis of the lower extremities, rheumatic valve diseases, and non-rheumatic valve diseases). For each cardiovascular disease, Mendelian randomization (MR) analyses were performed. Inverse variance-weighted meta-analysis (IVW) with a random-effects model was used as a principal analysis. In addition to this, the weighted median approach and MR-Egger method were used for further sensitivity analysis.ResultsIn the IVW analysis, genetically predicted anti-cytomegalovirus IgG levels were suggestively associated with coronary artery disease with an odds ratio (OR) of 1.076 [95% CI, 1.009–1.147; p = 0.025], peripheral artery disease (OR 1.709; 95% CI, 1.039–2.812; p = 0.035), and deep vein thrombosis (OR 1.002; 95% CI, 1.000–1.004; p = 0.025). In the further analysis, similar causal associations were obtained from weighted median analysis and MR-Egger analysis with lower precision. No notable heterogeneities and horizontal pleiotropies were observed (p > 0.05).Conclusions/InterpretationOur findings first provide direct evidence that genetic predisposition of anti-cytomegalovirus IgG levels increases the risk of coronary artery disease, peripheral artery disease, and deep vein thrombosis.

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Section: Discussionmentioning

confidence: 99%

Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Tan

Ren²,

Fan³

et al. 2022

Front. Cell. Infect. Microbiol.

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“… 143 CMV seropositivity is also associated with arterial thrombosis but is less convincing, with an odds ratio of 1.23. 144 , 145 according to the study by Atzmony et al, 146 the acute CMV infection‐associated thrombosis incidence amongst hospitalized patients was 6.4%: five (3.6%) patients who had arterial thrombosis and four (2.9%) patients who had VTE. However, the true thrombosis incidence is probably higher.…”

Section: Managementmentioning

confidence: 98%

“…It is recommended to keep an eye on bone marrow toxicity while using antiviral medications. 145 For anticoagulant therapy, the patients received medication based on guidelines for PE and thrombosis. For antiviral therapy, the patients received valganciclovir and/or ganciclovir for about 3 weeks, and Both groups attained good outcomes.…”

Section: Managementmentioning

confidence: 99%

“…According to a study by Paran et al, positive serology for CMV IgM is the modest independent predictor of VTE occurrence (odds ratio of 2.49 for VTE as a whole and 2.44 for PE or infarction and lower limb DVT). 145 It has been suggested to confirm the CMV infection with proper viral load testing (not static serology in isolation) as CMV IgM tends to stay positive for weeks to months after the acute infection. 144 , 145 , 183 …”

Section: Managementmentioning

confidence: 99%

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Venous thromboembolism in viral diseases: A comprehensive literature review

Zerangian

Erabi

Poudineh

et al. 2023

Health Science Reports

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Venous thromboembolism (VTE) is known to be a common respiratory and/or cardiovascular complication in hospitalized patients with viral infections. Numerous studies have proven human immunodeficiency virus infection to be a prothrombotic condition. An elevated VTE risk has been observed in critically ill H1N1 influenza patients. VTE risk is remarkably higher in patients infected with the Hepatitis C virus in contrast to uninfected subjects. The elevation of D‐dimer levels supported the association between Chikungunya and the Zika virus and the rise of clinical VTE risk. Varicella‐zoster virus is a risk factor for both cellulitis and the consequent invasive bacterial disease which may take part in thrombotic initiation. Eventually, hospitalized patients infected with the coronavirus disease of 2019 (COVID‐19), the cause of the ongoing worldwide pandemic, could mainly suffer from an anomalous risk of coagulation activation with enhanced venous thrombosis events and poor quality clinical course. Although the risk of VTE in nonhospitalized COVID‐19 patients is not known yet, there are a large number of guidelines and studies on thromboprophylaxis administration for COVID‐19 cases. This study aims to take a detailed look at the effect of viral diseases on VTE, the epidemiology of VTE in viral diseases, and the diagnosis and treatment of VTE.

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“…Human cytomegalovirus (HCMV) is a ds-DNA β-herpesvirus that is associated with mononucleosis syndrome (review in [242]), venous thromboembolism (VTE) (review in [242]), and cytomegalovirus encephalitis in immunocompromised patients (review in [243]). HCMV pUL97 is a multifunctional protein kinase that phosphorylates CDK1 and modifies the host G2/M cell cycle checkpoint regulators to promote viral replication [244].…”

Section: Herpes Simplex Virus Type-1 Human Cytomegalovirus and Epstein-barr Virusmentioning

confidence: 99%

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

Sajidah

Lim

Wong

2021

Cells

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The host nucleocytoplasmic trafficking system is often hijacked by viruses to accomplish their replication and to suppress the host immune response. Viruses encode many factors that interact with the host nuclear transport receptors (NTRs) and the nucleoporins of the nuclear pore complex (NPC) to access the host nucleus. In this review, we discuss the viral factors and the host factors involved in the nuclear import and export of viral components. As nucleocytoplasmic shuttling is vital for the replication of many viruses, we also review several drugs that target the host nuclear transport machinery and discuss their feasibility for use in antiviral treatment.

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Acute superior mesenteric vein thrombosis in the setting of cytomegalovirus mononucleosis: a case report and review of the literature

Cited by 6 publications

References 18 publications

Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Genetic Predisposition of Anti-Cytomegalovirus Immunoglobulin G Levels and the Risk of 9 Cardiovascular Diseases

Venous thromboembolism in viral diseases: A comprehensive literature review

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System

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