Acute suppression of TGF-ß with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants

Implantable batteryless device for on-demand and pulsatile insulin administration

“…5), fibrotic capsule formation around the nondegradable implant like the MDP was natural and inevitable39. Fibrotic capsule formation occurs gradually over weeks40, and thus to ensure reproducible systemic drug exposure, we envision delaying the operation of the MDP herein until formation of the fibrous capsule is complete15. Another clinical issue is local lipohypertrophy at the site of s.c. insulin injection41.…”

Polycaprolactone nanofibrous mesh reduces foreign body reaction and induces adipose flap expansion in tissue engineering chamber

“…43 However, overexpression of TGF-β often takes place during persistent chronic inflammation (eg, foreign body stimulation), leading to progressive capsule formation and subsequent capsule contraction. 19,44,45 There remains a high incidence of capsular contracture following cosmetic breast augmentation using silicone prosthesis. 46,47 When it occurs, the implant is crumpled or fractured, with visible deformity of the implant and breast.…”

“…Like all nonabsorbable implants, silicone may cause fibrous capsule formation of varying thickness. 18,19 Myofibroblasts are contractile fibroblasts found in fibrous capsule, which provide a contractile force and decrease the surface area of the capsule, leading to the capsule contracture over time. 20 Moreover, clinical study of capsular contractures after aesthetic breast augmentation revealed that the average tensile strength of the capsule was 44±38 N, 21 and the intracapsular pressure correlated positively with the degree of capsule thickness.…”

In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction

“…Connective tissue remodeling is a balanced process in between fibroblasts' extracellular matrix synthesis and matrix-metalloproteinase-catalyzed matrix degradation (Barron and Wynn, 2011). A key mediator function of TGF-β that shifts this balance towards a higher collagen deposition (Coker et al, 1997) is demonstrated in foreign-body-induced fibrosis (Park et al, 2015) as well as other chronic inflammatory processes like rheumatoid arthritis, intestinal inflammation, diabetic nephropathy or liver fibrosis (Pohlers et al, 2009).…”