Acute suppurative bacterial dacryoadenitis: a case series

Goold, Lucy A; Madge, Simon N.; Au, Alicia K.; Leibovitch, Igal; McNab, Alan A.; Tumuluri, Krishna; Selva, Dinesh

doi:10.1136/bjophthalmol-2012-302302

Cited by 32 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While we largely utilized HSV-1 for this study, the potential susceptibility of glands to a broader spectrum of pathogens should be appreciated. Cases of viral, bacterial, and fungal dacryoadenitis or inflammation of the lacrimal gland are seldom documented in humans, perhaps because treatment of the cornea may also serve to address simultaneous infection of ocular glands (22,37,38). While this study brings light to an unexplored area of ocular infection, further study is required to address the implications of glandular involvement on infection outcomes.…”

Section: Discussionmentioning

confidence: 97%

Ocular Glands Become Infected Secondarily to Infectious Keratitis and Play a Role in Corneal Resistance to Infection

Montgomery

Callegan

Fuller

et al. 2019

J Virol

View full text Add to dashboard Cite

Ocular glands play a critical role in eye health through the secretion of factors directly onto the ocular surface. The cornea is a normally transparent tissue necessary for visual acuity located in the anterior segment of the eye. Corneal damage can occur during microbial infection of the cornea, resulting in potentially permanent visual deficits. The involvement of ocular glands during corneal infection has been only briefly described. We hypothesized that ocular glands contribute to resistance as an arm of the eye-associated lymphoid tissue and may also be susceptible to infection secondary to microbial keratitis. Utilizing a mouse model of herpes simplex virus 1 (HSV-1) keratitis, we found that infection of corneas resulted in subsequent infection of ocular glands, including harderian glands (HGs) and extraorbital glands. Similarly, infection of corneas with Pseudomonas aeruginosa resulted in secondary infection of ocular glands. A robust immune response, characterized by increased numbers of immune cells and inflammatory mediators, occurred within ocular glands following HSV-1 keratitis. Removal of HGs altered corneal resistance to HSV-1, as measured by increased viral load, decreased corneal edema, and decreased inflammatory cell infiltration. These novel findings suggest that ocular glands are involved in microbial keratitis through their susceptibility to secondary infection and contribution to corneal resistance. IMPORTANCE Microbial keratitis accounts for up to 700,000 clinical visits annually in the United States. The involvement of ocular glands during microbial keratitis is not readily appreciated, and treatment options do not address the consequences of ocular gland dysfunction. The present study shows that ocular glands are susceptible to direct infection by common ocular pathogens, including HSV-1 and Pseudomonas aeruginosa, subsequent to microbial keratitis. Additionally, ocular glands contribute soluble factors that play a role in corneal resistance to HSV-1 and alter viral load, corneal edema, and immune cell infiltration. Further studies are needed to elucidate the mechanisms by which this occurs.

show abstract

Section: Discussionmentioning

confidence: 97%

Ocular Glands Become Infected Secondarily to Infectious Keratitis and Play a Role in Corneal Resistance to Infection

Montgomery

Callegan

Fuller

et al. 2019

J Virol

View full text Add to dashboard Cite

show abstract

“…Although the most common infective agents in the literature are viruses such as mumps, measles, Epstein-Barr, and influenza, more rarely bacterial factors have been listed as the cause of the acute suppurative dacryoadenitis with lacrimal gland abscess formation (3)(4)(5). In most cases, the abscess occurred after the systemic spread in immune-deficiency population or local spread from periocular infections or traumatic inoculation (6). The aim of this article is to report the acute spontaneous suppurative dacryoadenitis with abscess formation.…”

Section: Introductionmentioning

confidence: 99%

A Rare Case Report: Acute Spontaneous Suppurative Dacryoadenitis

Penbe¹

2018

Beyoglu Eye J

View full text Add to dashboard Cite

We report a case of acute suppurative bacterial dacryoadenitis with abscess formation which is rarely seen in daily practice. A 67-year-old male had been suffering from swelling and purulent discharge on the right eye consulted to our ophthalmology clinics. We noted the ocular and orbit computerized tomography findings for the diagnosis at the beginning. Furthermore, we described the treatment options and its conclusions with the help of its magnetic resonance imaging findings.

show abstract

“…The MRSA prevalence rate increased 12.1 % during the 5-year period (from 29.5 % in 2000 to 41.6 % in 2005) [114]. Amato et al [93] Small case series (based on microbiology results or drug trials) Shanmuganathan et al [123] Rutar et al [91] Adebayo et al [124] Lichtinger et al [95] Sotonzono et al [118] Case reports site-specific Lacrimal system Kotlus et al [90] Rutar [107] Kubal and Garibaldi [105] Chandravanshi et al [106] Gould et al [125] Conjunctiva Tarabishy et al [85] Cimolai [61] Ikeda et al [119] Mantadakis et al [113] Cellulitis Mehra et al [98] Charalampidou et al [99] Juthani et al [101] Vaska et al [104] Soon [100] Mathias et al [102] Endophthalmitis Deramo et al [96] Major et al [97] Ursea et al [126] Ho et al [86] Basu et al [62] Keratitis Sotozono et al [67] Lee et al [69] Chou et al [65] Post-surgical case reports Cataract surgery Cosar et al [75] Tang et al [70] Retinal surgery Oshima et al [68] Feiz and Redline [72] Rich et al [74] Pterygium surgery Lee et al [73] Curr…”

Section: Ophthalmic Resistance Of Mrsamentioning

confidence: 99%

Methicillin-Resistant Staphylococcus aureus and the Eye: Current Concepts and Management Strategies

Ritterband

2013

Curr Ophthalmol Rep

View full text Add to dashboard Cite

Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the most important causes of nosocomial infections worldwide. This review explores the history and epidemiology of MRSA infections with a detailed analysis of its molecular subtyping, target populations, virulence factors, and modes of transmission. In addition, it specifically discusses the spectrum of eye diseases caused by MRSA, reviews the current ophthalmic literature, addresses the controversy regarding ophthalmic antibiotic resistance to MRSA, and examines alternative treatment strategies.

show abstract

Acute suppurative bacterial dacryoadenitis: a case series

Abstract: ASBD is a rare condition that resolves quickly if managed appropriately. Underlying anatomical, infectious or inflammatory conditions should be investigated, and skin commensals should be covered with the instigation of antibiotic therapy.

Cited by 32 publications

References 17 publications

Ocular Glands Become Infected Secondarily to Infectious Keratitis and Play a Role in Corneal Resistance to Infection

Ocular Glands Become Infected Secondarily to Infectious Keratitis and Play a Role in Corneal Resistance to Infection

A Rare Case Report: Acute Spontaneous Suppurative Dacryoadenitis

Methicillin-Resistant Staphylococcus aureus and the Eye: Current Concepts and Management Strategies

Contact Info

Product

Resources

About