2018
DOI: 10.1016/j.redox.2017.10.004
|View full text |Cite
|
Sign up to set email alerts
|

Acute telomerase components depletion triggers oxidative stress as an early event previous to telomeric shortening

Abstract: Loss of function of dyskerin (DKC1), NOP10 and TIN2 are responsible for different inheritance patterns of Dyskeratosis congenita (DC; ORPHA1775). They are key components of telomerase (DKC1 and NOP10) and shelterin (TIN2), and play an important role in telomere homeostasis. They participate in several fundamental cellular processes by contributing to Dyskeratosis congenita through mechanisms that are not fully understood. Presence of oxidative stress was postulated to result from telomerase ablation. However, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
13
0
2

Year Published

2018
2018
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 26 publications
(16 citation statements)
references
References 59 publications
1
13
0
2
Order By: Relevance
“…Recently, the lack of the relationship between the rate of shortening of leukocyte telomeres and atherosclerosis has also been demonstrated in the small longitudinal study [18]. At the same time, José Santiago Ibáñez-Cabellos et al consider that oxidative stress is not the main cause of telomere shortening, and most likely oxidative stress is the potential cause of telomere shortening in those diseases, in which telomerase activity is impaired [6].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, the lack of the relationship between the rate of shortening of leukocyte telomeres and atherosclerosis has also been demonstrated in the small longitudinal study [18]. At the same time, José Santiago Ibáñez-Cabellos et al consider that oxidative stress is not the main cause of telomere shortening, and most likely oxidative stress is the potential cause of telomere shortening in those diseases, in which telomerase activity is impaired [6].…”
Section: Discussionmentioning
confidence: 99%
“…Telomeres are the terminal parts of a linear DNA molecule that are gradually shortened with every cell division. As soon as the length of telomeric DNA becomes dangerously short the induced cell aging launches while its metabolic activity remains maintained [5,6]. There is the evidence that the length of telomeres in leukocytes reflects the length of telomeres in stem cells and corresponds to their length in endothelial progenitor cells that allows us to consider this parameter as the biomarker of vascular aging.…”
mentioning
confidence: 99%
“…Suppressor of ras val-2 (SRV2), a newly discovered pro-fission protein, affects mitochondrial shape and activates mitochondrial fission via multiple mechanisms [11]. First, SRV2 can promote interactions between Drp1 and mitochondria [12]. Subsequently, SRV2 promotes oligomerization of Drp1, which then forms a ring around mitochondria that constricts and cuts them into several fragments.…”
Section: Introductionmentioning
confidence: 99%
“…When telomerase activity is disrupted in these cells, they lose replicative capacity and lose their pluripotency. In addition, this disruption leads to an increase in cellular oxidative stress [18].…”
Section: Introductionmentioning
confidence: 99%