1997
DOI: 10.1002/(sici)1097-4636(19970315)34:4<477::aid-jbm8>3.0.co;2-h
|View full text |Cite
|
Sign up to set email alerts
|

Acute thrombogenicity of intact and injured natural blood conduits versus synthetic conduits: Neutrophil, platelet, and fibrin(ogen) adsorption under various shear-rate conditions

Abstract: We investigated the acute thrombogenicity of synthetic arterial prostheses compared to biological arterial surfaces in contact with flowing nonanticoagulated blood. The acute events following blood/surface interactions were quantified using 51Cr-platelet deposition, 111In-neutrophil adhesion, and 125I-fibrin(ogen) adsorption on expanded polytetrafluoroethylene (ePTFE) synthetic arterial surfaces (Goretex and Impra) and on intact and injured biological arterial surfaces in ex vivo superfusion flow chambers at l… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
22
0

Year Published

2000
2000
2019
2019

Publication Types

Select...
7

Relationship

4
3

Authors

Journals

citations
Cited by 28 publications
(22 citation statements)
references
References 27 publications
0
22
0
Order By: Relevance
“…The specimen chamber assembly was placed in a thermostatically controlled water bath at 37°C. Under these conditions, the calculated wall shear rate corresponded to 424 s −1 in the 2.0 mm internal diameter of the specimen chambers (14).…”
Section: Methodsmentioning
confidence: 97%
See 2 more Smart Citations
“…The specimen chamber assembly was placed in a thermostatically controlled water bath at 37°C. Under these conditions, the calculated wall shear rate corresponded to 424 s −1 in the 2.0 mm internal diameter of the specimen chambers (14).…”
Section: Methodsmentioning
confidence: 97%
“…Catheters introduced into the femoral artery and vein were connected to an ex vivo flow circuit containing 4 cylindrical Plexiglas specimen chambers. Two pairs of chambers were connected in parallel by nontoxic, nonpyrogenic Tygon flexing tubing (14). At the beginning of the experiment, nonanticoagulated arterial blood was drawn through the circuit by means of a peristaltic pump and circulated back into the animal through the femoral vein for 15 min at a constant flow of 20 ml/min.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Platelet adhesion was conducted using plexiglas perfusion chambers that mimic the tube-like cylindrical shape of blood vessels, as described previously [28, 29]. The samples (bare PET, LP-coated PET, and PEG-coated PET prepared with 5% w/v PEG were placed in the perfusion chambers containing a window of 2 mm internal diameter ×  10 mm long, permitting direct exposure of the samples to the blood.…”
Section: Methodsmentioning
confidence: 99%
“…Poly(ethylene terephthalate) (PET, Dacron) and expanded poly(tetrafluoroethylene) (ePTFE) grafts have been used extensively over the years in vascular repair. These materials have good mechanical properties, are quite inert and exhibit low thrombogenicity 1–3. This might be favorable to avoid thrombotic occlusion or stenosis in small‐diameter artificial vessels.…”
Section: Introductionmentioning
confidence: 99%