Concentrations of trace elements and organic pollutants were determined in marine sediments and molluscs from the Mediterranean and Red Sea coasts of Israel. Two bivalve species (Donax trunculus, Pteria aegyptia), two gastropod species (Patella caerulea, Cellana rota) and sediments were sampled at polluted and relatively clean, reference, sites. Along the Mediterranean coast of Israel, sediments and molluscs from Haifa Bay stations were enriched with both organic and trace element contaminants. In the Red Sea, differences between the polluted and reference sites were less pronounced. Bio-concentration factors indicate a significant concentration of Zn, As, Cd, Sn and Pb in animal tissue relative to the concentrations of these elements in the sediments. In contrast, Ce, La and U were not concentrated in molluscs. The trace element results indicate a saturation of the detoxification mechanisms in molluscs from polluted sites. The concentrations of organic pollutants at the same sites are at the lower range of values recorded in other studies. However, synergistic effects between these compounds and between them and metals can lead to acute toxicity.