Acute toxicity profile of cadmium revealed by proteomics in brain tissue of Paralichthys olivaceus: Potential role of transferrin in cadmium toxicity

Zhu, Jinyong; Huang, Heqing; Bao, Xiaodong; Lin, Qingmei; Cai, Zongwei

doi:10.1016/j.aquatox.2006.02.010

Cited by 78 publications

(36 citation statements)

References 27 publications

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“…However, it is difficult to translate the calculated probability into the common language of traditional statistics. Therefore, Profound also provides a Z score, which was estimated as an indicator of the quality of the search result when the search result was compared against an estimated random match population 22 . The Z score is the distance to the population mean in standard deviation units.…”

Section: Differentially Expressed Protein Identificationmentioning

confidence: 99%

Proteomic analysis of silver nanoparticle toxicity in rat

Kim

Chu

Han

et al. 2010

Toxicol. Environ. Health. Sci.

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Silver nanoparticles (SNPs) have received considerable attention recently, because SNPs with different shapes and sizes exhibit variable antimicrobial activity, which makes them useful for medical and hygienic purposes. SNPs have been detected in various tissues and organisms after inhalation, oral ingestion, and contact with the skin, indicating that SNPs can be distributed to different body tissues after uptake. Thus, the toxicity of SNPs to different body tissues after their uptake needs to be studied. In this study, we performed a proteomic analysis of liver, lung, and kidney tissues in rats exposed to approximately 50 nm SNPs by intravascular injection. Then, the differentially expressed proteins representing a dose-dependent response were identified. The differentially expressed proteins were mostly related to the known toxicity of SNPs, such as apoptosis, increased reactive oxygen species, thrombus formation, and inflammation. Additionally, proteins related to metabolic disorders including diabetes were identified as differentially expressed proteins in kidney, based solely on the analysis of the protein profile and related disease pathway. In conclusion, the differentially expressed proteins identified in this study could provide basic data for understanding the toxic and pathological responses of SNP-exposed tissues and to identify candidate SNP toxicity biomarkers.

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Section: Differentially Expressed Protein Identificationmentioning

confidence: 99%

Proteomic analysis of silver nanoparticle toxicity in rat

Kim

Chu

Han

et al. 2010

Toxicol. Environ. Health. Sci.

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“…That study [6] was the first to apply this technique to aquatic toxicology and proved its utility and power. Proteomic research on non-model fish species have examined physiological responses to endocrine disrupting compounds [33,34], Cd [36,37], and microcystin-LR [7,38,39], among other environmental contaminants [30]. Protein profiles have mostly been evaluated in hepatic tissues, but occasionally in gill [37], brain [36], and kidney tissues [40].…”

Section: Non-model Fish Speciesmentioning

confidence: 99%

Review of recent proteomic applications in aquatic toxicology

Sanchez

Ralston-Hooper

Sepúlveda

2010

Enviro Toxic and Chemistry

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Abstract-Over the last decade, the environmental sciences have witnessed an incredible movement towards the utilization of highthroughput molecular tools that are capable of detecting simultaneous changes of hundreds, and even thousands, of molecules and molecular components after exposure of organisms to different environmental stressors. These techniques have received a great deal of attention because they not only offer the potential to unravel novel mechanisms of physiological and toxic action but are also amenable to the discovery of biomarkers of exposure and effects. In this article, we review the state of knowledge of one of these tools in ecotoxicological research: proteomics. We summarize the state of proteomics research in fish, and follow with studies conducted with aquatic invertebrates. A brief discussion on proteomic methods is also presented. We conclude with some ideas for future proteomic studies with fish and aquatic invertebrates. Environ. Toxicol. Chem. 2011;30:274-282. # 2010 SETAC

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“…There are a number of laboratory-based exposures for proteomics, using diverse fish species [41][42][43][44]. However, there are comparatively fewer for field studies.…”

Section: Proteomic Field-based Studiesmentioning

confidence: 99%

Defining the role of omics in assessing ecosystem health: Perspectives from the Canadian environmental monitoring program

Bahamonde

Feswick

Isaacs

et al. 2015

Enviro Toxic and Chemistry

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Scientific reviews and studies continue to describe omics technologies as the next generation of tools for environmental monitoring, while cautioning that there are limitations and obstacles to overcome. However, omics has not yet transitioned into national environmental monitoring programs designed to assess ecosystem health. Using the example of the Canadian Environmental Effects Monitoring (EEM) program, the authors describe the steps that would be required for omics technologies to be included in such an established program. These steps include baseline collection of omics endpoints across different species and sites to generate a range of what is biologically normal within a particular ecosystem. Natural individual variability in the omes is not adequately characterized and is often not measured in the field, but is a key component to an environmental monitoring program, to determine the critical effect size or action threshold for management. Omics endpoints must develop a level of standardization, consistency, and rigor that will allow interpretation of the relevance of changes across broader scales. To date, population-level consequences of routinely measured endpoints such as reduced gonad size or intersex in fish is not entirely clear, and the significance of genome-wide molecular, proteome, or metabolic changes on organism or population health is further removed from the levels of ecological change traditionally managed. The present review is not intended to dismiss the idea that omics will play a future role in large-scale environmental monitoring studies, but rather outlines the necessary actions for its inclusion in regulatory monitoring programs focused on assessing ecosystem health. Environ Toxicol Chem 2016;35:20-35. # 2015 SETAC

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Acute toxicity profile of cadmium revealed by proteomics in brain tissue of Paralichthys olivaceus: Potential role of transferrin in cadmium toxicity

Cited by 78 publications

References 27 publications

Proteomic analysis of silver nanoparticle toxicity in rat

Proteomic analysis of silver nanoparticle toxicity in rat

Review of recent proteomic applications in aquatic toxicology

Defining the role of omics in assessing ecosystem health: Perspectives from the Canadian environmental monitoring program

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