Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

Kumar, Rajiv; Gupta, Manoj; Gupta, Vineet; Kaur, Amarjit; Gupta, Sunil Kumar

doi:10.7860/jcdr/2014/7761.4027

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…The association of FNHTR's with PRBC transfusions was found to be significant ( P < 0.05). A greater incidence of FNHTRs with PRBCs was also observed in a study done by Kumar et al [ 9 ] The relatively fewer number of platelet transfusions ( n = 246) as compared to whole blood ( n = 1467) and PRBCs ( n = 1042) could be a reason for nondetection of any reactions with platelets. In a study done at AIIMS,[ 10 ] the frequency of FNHTRs with PRBCs was found to be 0.04%, which was lower than that observed in this study.…”

Section: Discussionsupporting

confidence: 64%

“…In this study, the frequency of ATRs was observed to be 0.92%, which was comparable to that of a study carried out in Punjab, where the incidence of ATRs was 1.09%. [ 9 ] Two larger studies done in New Delhi and Chandigarh, however, showed a relatively lower frequency of transfusion reactions (0.05% and 0.18%, respectively). [ 10 11 ] A study in Switzerland[ 12 ] and the Quebec hemovigilance system[ 13 ] reported transfusion reaction rates of 0.042% and 0.035%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

2015

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Objective:Blood transfusions are inherently associated with risks ranging in severity from minor to life-threatening. Continuous monitoring of transfusion related complications can promote understanding of factors contributing to transfusion reactions and help to formulate necessary remedial measures. This study was designed to analyze the frequency and nature of transfusion reactions reported to the blood bank of a remote North East Indian teaching hospital.Materials and Methods:All acute transfusion reactions (ATRs) reported to the blood bank over a period of 20 months (May 2013 to January 2015) were reviewed and analyzed. The risk of transfusion reactions associated with each individual component was assessed.Results:A total of 3455 units of whole blood and component transfusions were carried out of which a total of 32 (0.92%) ATRs were encountered. Packed red blood cells (PRBCs) (n = 15, P = 0.06) and whole blood (WB) (n = 13, P = 0.83) were most commonly implicated. Allergic reaction was the most frequent transfusion reaction encountered (65.6%), seen most commonly with PRBC (risk of 0.76%, P = 0.42), and WB (risk of 0.68%, P = 0.63) transfusions. This was followed by febrile reactions (28.1%), which were seen more commonly with PRBCs (risk of 0.57%, P = 0.016). No reactions were observed with platelet transfusions.Conclusion:The overall incidence of transfusion reactions in this hospital is slightly higher than those having more advanced transfusion facilities in India. The lack of leukoreduction facilities in our hospital could be a likely cause for the same. The use of leukoreduced WB and PRBCs could possibly reduce the overall incidence of ATRs in general and febrile nonhemolytic transfusion reactions in particular.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

2015

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“…Of these, 77 were included. Through handsearching, we also found three additional reports and/or articles that were eligible for inclusion, 22–24 making a total of 80 studies for the final meta‐analysis 25–96 . The UK's Serious Hazards of Transfusion (SHOT) issues annual reports of transfusion‐related adverse events, and we were able to include data from 2003 to 2022, with the exception of 2009 in which the Supplementary Tables were not available for that year.…”

Section: Resultsmentioning

confidence: 99%

The incidence of transfusion‐related acute lung injury using active surveillance: A systematic review and meta‐analysis

White,

Walker,

Schmidt

et al. 2023

Transfusion

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BackgroundTransfusion‐related acute lung injury (TRALI) is a leading cause of transfusion‐related mortality. A concern with passive surveillance to detect transfusion reactions is underreporting. Our aim was to obtain evidence‐based estimates of TRALI incidence using meta‐analysis of active surveillance studies and to compare these estimates with passive surveillance.Study Design and MethodsWe performed a systematic review and meta‐analysis of studies reporting TRALI rates. A search of Medline and Embase by a research librarian identified studies published between January 1, 1991 and January 20, 2023. Prospective and retrospective observational studies reporting TRALI by blood component (red blood cells [RBCs], platelets, or plasma) were identified and all inpatient and outpatient settings were eligible. Adult and pediatric, as well as general and specific clinical populations, were included. Platelets and plasma must have used at least one modern TRALI donor risk mitigation strategy. A random effects model estimated TRALI incidence by blood component for active and passive surveillance studies and heterogeneity was examined using meta‐regression.ResultsEighty studies were included with approximately 176‐million blood components transfused. RBCs had the highest number of studies (n = 66) included, followed by platelets (n = 35) and plasma (n = 34). Pooled TRALI estimates for active surveillance studies were 0.17/10,000 (95% confidence intervals [CI]: 0.03–0.43; I2 = 79%) for RBCs, 0.31/10,000 (95% CI: 0.22–0.42; I2 = <1%) for platelets, and 3.19/10,000 (95% CI: 0.09–10.66; I2 = 86%) for plasma. Studies using passive surveillance ranged from 0.02 to 0.10/10,000 among the various blood components.DiscussionIn summary, these estimates may improve a quantitative understanding of TRALI risk, which is important for clinical decision‐making weighing the risks and benefits of transfusion.

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“…18 Sejalan dengan penelitian Kumar, dkk bahwa demam adalah gejala reaksi transfusi akut paling banyak terjadi oleh transfusi darah PRC (packed Red Cells) sebanyak 110 kejadian dari 166 (66,2%). 19…”

Section: Penutupunclassified

Prevalensi Reaksi Transfusi Darah Penderita Talasemia Beta Mayor yang Bergantung Transfusi di RSD Idaman Banjarbaru Tahun 2020-2021

Salsabila

Ringoringo²,

Panghiyangani

et al. 2022

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Patients with beta thalassemia major require regular and routine blood transfusions throughout life to maintain hemoglobin levels in order to survive. Blood transfusion in patients with beta thalassemia major who depend on transfusion can cause side effects and unwanted transfusion reactions. Transfusion reactions range from mild to life-threatening. The purpose of this study was to obtain data on the prevalence of transfusion reactions in transfusion-dependent beta thalassemia patients at Idaman Hospital Banjarbaru in 2020-2021. This study is a descriptive study that was taken retrospectively using patient medical record data. The results showed that there were 131 data on blood transfusion reactions of patients with beta thalassemia major who were dependent on transfusion from a total of 1591 data on transfusion at Idaman Hospital Banjarbaru for the period October 2020 - September 2021 with a prevalence of 8.2%. Moderate-severe transfusion reactions were the most common type, with 90 blood transfusion reactions (68.7%). The five main symptoms of a blood transfusion reaction that occur are fever, chills, pruritus, angioedema, and urticaria. All transfusion reactions that occurred were acute transfusion reactions and used PRC blood components. Keywords: beta thalassemia major, transfusion dependent, blood transfusion, transfusion reactions, PRC (Packed Red Cells) Abstrak: Pasien talasemia beta mayor memerlukan transfusi darah secara teratur dan rutin sepanjang hidup untuk mempertahankan kadar hemoglobin guna bertahan hidup. Transfusi darah pada penderita talasemia beta mayor yang bergantung transfusi dapat menimbulkan efek samping dan reaksi transfusi yang tidak diinginkan. Reaksi transfusi tersebut dari ringan sampai mengancam jiwa. Tujuan penelitian ini adalah memperoleh data prevalensi reaksi transfusi penderita talasemia beta mayor yang bergantung transfusi di RSD Idaman Banjarbaru Tahun 2020-2021. Penelitian ini merupakan penelitian deskriptif yang diambil secara retrospektif menggunakan data rekam medis pasien. Hasil penelitian menunjukkan bahwa terdapat 131 data reaksi transfusi darah penderita talasemia beta mayor yang bergantung transfusi dari total 1591 data transfusi di RSD Idaman Banjarbaru periode Oktober 2020 – September 2021 dengan prevalensi sebesar 8,2%. Reaksi transfusi sedang-berat merupakan jenis yang paling banyak terjadi sebanyak 90 reaksi transfusi darah (68,7%). Lima gejala utama dari reaksi transfusi darah yang terjadi adalah demam, menggigil, pruritus, angioedema, dan urtikaria. Semua reaksi tranfusi yang terjadi adalah reaksi transfusi akut dan menggunakan jenis komponen darah PRC. Kata-kata kunci: talasemia beta mayor, bergantung transfusi, transfusi darah, reaksi transfusi, PRC (Packed Red Cells)

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Acute Transfusion Reactions (ATRs) in Intensive Care Unit (ICU): A Retrospective Study

Cited by 10 publications

References 12 publications

Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

Study of acute transfusion reactions in a teaching hospital of Sikkim: A hemovigilance initiative

The incidence of transfusion‐related acute lung injury using active surveillance: A systematic review and meta‐analysis

Prevalensi Reaksi Transfusi Darah Penderita Talasemia Beta Mayor yang Bergantung Transfusi di RSD Idaman Banjarbaru Tahun 2020-2021

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