Acute transverse myelitis after COVID-19 pneumonia

Munz, Maike; Weßendorf, Swen; Koretsis, Georgios; Tewald, Friedemann; Baegi, Reem; Kramer, Stella; Geißler, Michael; Reinhard, Matthias

doi:10.1007/s00415-020-09934-w

Cited by 132 publications

(198 citation statements)

References 8 publications

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“…This profile is in line with the clinical reports of COVID-19-associated acute necrotizing myelitis 33 , where lymphocytic pleocytosis was observed in the cerebrospinal fluid (CSF). Acute transverse myelitis related to SARS-CoV-2 infection 24 , where an intense leukocyte infiltrate of monocytic characteristic and elevated protein level was also observed in the CSF. In another report, thrombosis in superficial and deep systems, straight sinus, the vein of Galen, internal cerebral veins, and thrombosis of the deep medullary veins were found 27 .…”

Section: Discussionmentioning

confidence: 97%

“…In this sense, the antibody transfer shown in zebrafish could be helpful in future studies to understand the maternal immunological protection of descendants against SARS-CoV-2 or any other vaccine candidates. Also, measuring antibodies against the rSpike in plasma and egg demonstrates great potential for the use of zebrafish in the early stages (phases I and II) of the development and use of these antibodies in therapeutics and prophylactics for humans 24,25 .…”

Section: Discussionmentioning

confidence: 99%

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Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

Fernandes¹,

Feitosa²,

Barbosa³

et al. 2020

Preprint

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Establishing new experimental animal models to assess the safety and immune response to the antigen used in the development of COVID-19 vaccine is an imperative issue. Based on the advantages of using zebrafish as a model in research, herein we suggest doing this to test the safety of the putative vaccine candidates and to study immune response against the virus. We produced a recombinant N-terminal fraction of the Spike SARS-CoV-2 protein and injected it into adult female zebrafish. The specimens generated humoral immunity and passed the antibodies to the eggs. However, they presented adverse reactions and inflammatory responses similar to severe cases of human COVID-19. The analysis of the structure and function of zebrafish and human Angiotensin-converting enzyme 2, the main human receptor for virus infection, presented remarkable sequence similarities. Moreover, bioinformatic analysis predicted protein-protein interaction of the Spike SARS-CoV-2 fragment and the Toll-like receptor pathway. It might help in the choice of future therapeutic pharmaceutical drugs to be studied. Based on the in vivo and in silico results presented here, we propose the zebrafish as a model for translational research into the safety of the vaccine and the immune response of the vertebrate organism to the SARS-CoV-2 virus.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Zebrafish studies on the vaccine candidate to COVID-19, the Spike protein: Production of antibody and adverse reaction

Fernandes¹,

Feitosa²,

Barbosa³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Little is known about association between SARS-CoV-2 and acute myelitis. Up to date, 7 cases of acute myelitis, alone (4 cases) or combined with brain involvement (3 cases), have been reported in relation to COVID-19 ( AlKetbi et al, 2020 , Munz et al, 2020 , Novi et al, 2020 , Sarma and Bilello, 2020 , Valiuddin et al, 2020 , Wong, Craik, 2020a, Zanin, Saraceno, 2020). Six patients (28–64 years age range, 57.1% female) variably had symptoms of COVID-19 (fever, dyspnea, malaise, chills, and rhinorrhea) 25 to 2 days prior the onset of neurologic symptoms of myelitis ( Table 3 ).…”

Section: Neurologic Manifestationsmentioning

confidence: 99%

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation

Keyhanian

Umeton

Mohit

et al. 2021

Journal of Neuroimmunology

121

146

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Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

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“…Recently, Franceschi et al describe 2 COVID-19 patients whose brain imaging suggested hemorrhagic posterior reversible encephalopathy syndrome [29] . The authors summarized three mechanisms of PRES: cytokine release syndrome which breaks down the BBB; hypoxia caused by inflammation; unstable blood pressure [59] , [60] , [61] .…”

Section: Neurological Manifestations Of Covid-19mentioning

confidence: 99%