The nervous system—A new territory being explored of SARS-CoV-2

Zhang, Meng; Zhou, Lingyan; Wang, Jing; Wang, Kun; Wang, Yuan; Xu-dong, Pan; Ma, Aijun

doi:10.1016/j.jocn.2020.10.056

Cited by 3 publications

(3 citation statements)

References 73 publications

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“…This case shows the neuroinvasive potentials of SARS-CoV-2 and the possibility of disease reactivation after clinical and analytic recovery. SARS-CoV-2 might be latent in some neurons to hide from immune surveillance (Brandt and Dieterich, 2017 ; Zhang M. et al, 2020 ). For reasons unclear, after an apparent remission the virus reactivated and was again identifiable in the respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Recurrence, Reactivation, or Inflammatory Rebound of SARS-CoV-2 Infection With Acute Vestibular Symptoms: A Case Report and Revision of Literature

Zaffina

Lanteri

Gilardi

et al. 2021

Front. Hum. Neurosci.

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A case of recurrent coronavirus disease 2019 (COVID-19) with neurovestibular symptoms was reported. In March 2020, a physician working in an Italian pediatric hospital had flu-like symptoms with anosmia and dysgeusia, and following a reverse transcription PCR (RT/PCR) test with a nasopharyngeal swab tested positive for SARS-CoV-2. After home quarantine, 21 days from the beginning of the symptoms, the patient tested negative in two subsequent swabs and was declared healed and readmitted to work. Serological testing showed a low level of immunoglobulin G (IgG) antibody title and absence of immunoglobulin M (IgM). However, 2 weeks later, before resuming work, the patient complained of acute vestibular syndrome, and the RT/PCR test with mucosal swab turned positive. On the basis of the literature examined and reviewed for recurrence cases and vestibular symptoms during COVID-19, to our knowledge this case is the first case of recurrence with vestibular impairment as a neurological symptom, and we defined it as probably a viral reactivation. The PCR retest positivity cannot differentiate re-infectivity, relapse, and dead-viral RNA detection. Serological antibody testing and viral genome sequencing could be always performed in recurrence cases.

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Section: Discussionmentioning

confidence: 99%

Recurrence, Reactivation, or Inflammatory Rebound of SARS-CoV-2 Infection With Acute Vestibular Symptoms: A Case Report and Revision of Literature

Zaffina

Lanteri

Gilardi

et al. 2021

Front. Hum. Neurosci.

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“…Hitherto unexpected SARS-CoV-2 neurotropism emerged [31] , and the underlying mechanism has been object of intense investigation. From the very beginning of the pandemics, a variety of neurological symptoms, including loss of smell (hyposmia) and taste (hypogeusia), headache, nausea, vomiting, fatigue, have been reported in subjects affected by COVID-19 [24] , [32] , [33] . Additional neurological complications include stroke, impaired consciousness, seizures, and encephalopathy [24] , [25] .…”

Section: Neurotropism Of Sars-cov-2 Short-circuits the Neural Cardiovmentioning

confidence: 99%

Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development

Lionetti

Coppini

Gerbino

et al. 2021

Pharmacological Research

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In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.

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“…On March 4, 2020, at Beijing, China, the first case of CNS involvement with cerebrospinal fluid (CSF) positive Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Américas, Risaralda, Pereira, Colombia for SARS-CoV-2 by sequencing was confirmed (Zhang et al 2020). As the COVID-19 pandemic progressed, laboratory data showed that the overall yield of RT-PCR in CSF was low, and, despite many patients exhibiting signs of CNS involvement, most test were negative, making the diagnosis challenging.…”

Section: Introductionmentioning

confidence: 99%

Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia

et al. 2021

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The nervous system—A new territory being explored of SARS-CoV-2

Abstract: Highlights neurological properties of SARS-CoV-2. mechanism of COVID-19. neurological manifestations of SARS-CoV-2(CNS and PNS) the significance of the neuroinvasion. comparison with other viral respiratory infections.

Cited by 3 publications

References 73 publications

Recurrence, Reactivation, or Inflammatory Rebound of SARS-CoV-2 Infection With Acute Vestibular Symptoms: A Case Report and Revision of Literature

Recurrence, Reactivation, or Inflammatory Rebound of SARS-CoV-2 Infection With Acute Vestibular Symptoms: A Case Report and Revision of Literature

Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development

Acute meningoencephalitis associated with SARS-CoV-2 infection in Colombia

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