To block or not to block, that is the question.
CLINICAL HISTORIESCase 1.-This is a 53-year-old male seen for consultation due to headaches since high school, which have been almost daily for the past 20 years. He describes a throbbing pain behind the left eye, with an intensity of 5-9/10 and posterior cervical pressure, occasionally associated with nausea and vomiting, but no light or sound sensitivity. He takes rizatriptan 10 mg daily, and the headache is gone in about 1 hour. Every couple of weeks, the headache recurs and he takes another dose of rizatriptan. He takes hydrocodone 1-2 tablets every couple of weeks. Alcohol triggers his headaches. Sumatriptan injections and baclofen did not help. He has tried topiramate, amitriptyline, divalproex sodium, gabapentin, and propranolol for headache prevention, without help. He also tried onabotulinumtoxinA once, without help. Chiropractic treatment did not help. He has not tried acupuncture. Magnetic resonance imaging of the brain with and without contrast, done 3 months previously, was negative. He has a past medical history of hyperlipidemia, treated with a statin. Neurological examination was normal. There was bilateral greater occipital nerve (GON) tenderness. Bilateral greater occipital nerve block (GONB) was performed by injection of 3 mL of 1% lidocaine 2 cm lateral and 2 cm inferior to the inion on each side. For headache prevention, he was started on zonisamide 100 mg daily for 2 weeks and then 200 mg daily. He was informed on the risk of medication overuse headache with frequent use of rizatriptan. He was seen in follow-up 2 months later. During the 2 weeks after the occipital nerve blocks (ONBs), he had one headache that was quickly relieved by rizatriptan. For the following 14 days, he experienced headaches once every other day, and thereafter his daily headache pattern resumed, with prompt relief by rizatriptan.Case 2.-This is a 45-year-old woman with a 15-year history of migraine without aura occurring about 2-3 times per month. She takes eletriptan 40 mg tablets, with relief of the headache in 2 hours. She presents with a 2-day history of a typical right-sided throbbing headache of 9/10 intensity, associated with nausea, vomiting, as well as light and sound sensitivity. Her symptoms did not respond to 2 doses of eletriptan and promethazine suppository. A right GONB was performed by injection of 3 mL of 1% lidocaine 2 cm lateral and 2 cm inferior to the inion, with relief of the headache within 10 minutes. Subsequently, she has had 2 similar episodes that were quickly relieved by ONBs.Case 3.-This is a 58-year-old male seen in consultation with headaches since high school, which have been daily for the past month. Prior to that, he had approximately 4 headache days per week for many years. He describes a bilateral retro-orbital and temporal pain with nuchal-occipital throbbing and pres-